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K L Kennedy

Publications and source records attributed to K L Kennedy.

13 recordsLinked to original sources
PubMed2002

Evaluation of the efficacy of antipsychotic attenuation of phencyclidine-disrupted prepulse inhibition in rats.

SUMMARY: Phencyclidine reliably disrupts prepulse inhibition of the acoustic startle response in rats. Previous research has suggested that atypical antipsychotics (e.g., those that do not produce extrapyramidal motor effects) attenuate the disruptive effects of phencyclidine in this model whereas typical antipsychotics do not. Nearly all of this research has used the D2 antagonist haloperidol for comparison. In this study, antipsychotics with more diverse receptor binding profiles were tested for their efficacy in attenuating phencyclidine-induced disruption of prepulse inhibition. Results showed that phencyclidine disrupted prepulse inhibition in all groups of rats. Olanzapine, but not clozapine, attenuated this disruption, but this effect occurred only at a single (5 mg/kg) dose. None of the other antipsychotics nor spermine altered phencyclidine's effects. These results suggest that this model does not reliably differentiate between typical and atypical antipsychotics.

Animals↗
PubMed2001

Prevalence of hypersensitivity to specific fungal allergens as determined by intradermal dilutional testing.

OBJECTIVE: To determine fungal allergen reactivity prevalence by intradermal dilutional testing in patients with and without chronic rhinitis or rhinosinusitis symptoms. STUDY DESIGN: Prospective comparison of fungal allergen reactivity prevalence in symptomatic and asymptomatic patients. SETTING: University medical center. METHODS: Group I (chronic rhinitis and/or rhinosinusitis symptoms) and Group II (asymptomatic) patients underwent intradermal dilutional testing with usual and fungal allergens. RESULTS: Fungal reactivity occurred in 65% (13/20) of Group I, and 13% (4/30) of Group II (P < 0.0002 by chi(2) testing). Group I was more reactive to non-fungal allergens (85% vs. 33%, p < 0.0004), and to all allergens considered together (95% vs. 40%, p < 0.0001). CONCLUSIONS: Patients with chronic rhinitis and rhinosinusitis symptoms were more reactive to fungal and nonfungal allergens. Fungal allergens were as likely as nonfungal to elicit reactivity. SIGNIFICANCE: These findings suggest a role for fungal hypersensitivity in chronic rhinitis and chronic rhinosinusitis.

Adult↗
PubMed1995

Urinary incontinence: the basics.

Urinary incontinence (UI) is a widely prevalent problem that affects people of all ages and levels of physical health, both in healthcare settings and in the community. Contributing to the problem are that many practitioners remain uneducated about this condition, individuals are often too ashamed or embarrassed to seek professional help, and there are significant variations in diagnostic and treatment practices. Five types of UI are stress, urge, overflow, functional and manufactured incontinence. Stress, urge and overflow are caused by factors within the urinary tract and will be concentrated on in this article. To diagnose UI a three-part assessment should be conducted, including the patient history, physical examination, and urinalysis. A behavioral program should be designed which incorporates identification and education for both patient and clinician. Treatment options include pelvic floor exercises (Kegel), vaginal cones, bladder training (retraining), habit training (timed voiding), electrostimulation and biofeedback, clean intermittent catheterization, indwelling catheters, medications, collagen injections, surgery, and absorption products. Most patients can be helped dramatically or cured with the appropriate treatment.

Adolescent↗
PubMed1995

Challenging wounds in the home care environment.

Although principles of wound care management are the same as any other means of healthcare delivery, how you deliver care in the home is different. Patients in the home care setting have very different needs than patients in more controlled environments. When dealing with patients in the home setting there are more obstacles to overcome than in environments such as the hospital or extended care facility. Getting the patient to comply to the orders you give can be difficult. Also, the goals of patients do not always match the goals of their healthcare providers. Therefore, the caregiver must alter the goals of treatment accordingly for each patient. This manuscript illustrates two case studies in which the needs and priorities of the home care patient guided changes in the goals of caregiving.

Aged↗