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Biomedical subjects

K L Monti

Publications and source records attributed to K L Monti.

8 recordsLinked to original sources
PubMed1997

The use of EMLA cream and 1% lidocaine infiltration in men for relief of pain associated with the removal of genital warts by cryotherapy.

BACKGROUND: Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration. OBJECTIVE: Our purpose was to determine the efficacy of topically applied lidocaine/prilocaine cream to reduce the pain of lidocaine infiltration and the pain associated with cryotherapy to remove genital warts. METHODS: Men, scheduled for removal of genital warts by cryotherapy, were randomly selected to receive one of three treatments: (1) lidocaine/prilocaine cream application, (2) 1% lidocaine infiltration, and (3) lidocaine/prilocaine cream application followed by infiltration of 1% lidocaine. RESULTS: Application of lidocaine/prilocaine cream for 15 minutes markedly reduced the pain of lidocaine infiltration. The combination of lidocaine/prilocaine cream followed by infiltration of 1% lidocaine gave greater pain relief from the cryotherapy than did either anesthetic alone. CONCLUSION: The application of lidocaine/prilocaine cream as an adjunct to lidocaine infiltration reduced the pain of infiltration and the pain associated with cryotherapy for the removal of genital warts.

Anesthesia, Local↗
PubMed1995

A simple, graphical method to evaluate laboratory assays.

Evaluation methods of laboratory assays often fail to predict the large, infrequent errors that are a major source of clinician complaints. We present a simple, graphical method to evaluate laboratory assays, which focuses on detecting large, infrequent errors. Our method, the folder empirical cumulative distribution plot or, more simply, mountain plot, is prepared by computing a percentile for each ranked difference between the new and reference method. To get a folded plot, one performs the following subtraction for all percentiles over 50: percentile = 100 - percentile. Percentiles (y axis) are then plotted against differences or percent differences (x axis). The calculations and plots are simple enough to perform in a spreadsheet. We also offer Windows based software to perform all calculations and plots. The mountain plot compared to the difference plot focuses attention on two features of the data: the center and the tails. We prefer the mountain plot over other graphical techniques because: 1. It is easier to find the central 95% of the data. 2. It is easier to estimate percentile for large differences (e.g., percentiles greater than 95%). 3. Unlike a histogram, the plot shape is not a function of the intervals. 4. Comparing different distributions is easier. 5. The plot is easier to interpret than a standard empirical cumulative distribution plot. Difference and mountain plots each provide complementary perspectives on the data. We recommend both plots. This method can also be used with data from a wide variety of other applications such as clinical trials and quality control.

Chemistry, Clinical↗
PubMed1993

Effects of dietary electrolyte balance on subluxation of the femoral head in growing dogs.

Effects of increased dietary chloride and reduced sodium and potassium ion concentrations on coxofemoral joint conformation, as assessed by radiography, were examined in growing dogs. Dietary electrolyte balance was quantified by dietary anion gap (DAG), defined as Na+ + K+ - Cl- in milli-equivalents per 100 g of food. Diets had anion gap ranging from 8 to 41 mEq/100 g of food. One hundred sixty-seven pups from 27 litters representing 5 breeds were studied during the period of rapid growth. The extent of subluxation of the femoral head was measured on radiographs, using the method of Norberg. On average, less subluxation of the femoral head (P < 0.05) was observed when diets with lower DAG were fed. Differences in DAG balance did not result in different rates of weight gain; therefore, the reduction in coxofemoral joint subluxation attributable to low DAG was unrelated to weight gain. Norberg angles measured at 30 weeks of age were highly correlated with coxofemoral joint status at 2 years of age, as measured by the Swedish diagnostic system and the scoring system of the Orthopedic Foundation for Animals (lrl > or = 0.70, P < 0.0002, n = 24). This diet-related improvement in coxofemoral joint subluxation would be expected, on average, to delay or mitigate the characteristic clinical and radiographic signs of hip dysplasia in growing dogs.

Animals↗
PubMed1992

Effects of limited food consumption on the incidence of hip dysplasia in growing dogs.

Forty-eight 8-week-old Labrador Retrievers were allotted to 2 groups of 24 dogs each; 1 group was fed ad libitum and the other group was given 25% less of the same feed until the dogs were 2 years old. Radiography of the hip joints was done when the dogs were 30, 42, 54, 78, and 104 weeks old. Subluxation was measured by the Norberg angle on radiographs made with the dog in the standard (extended limb) position. Independent of age at which the radiography was done, there was less subluxation of the femoral heads in the limit-fed dogs. Using the Swedish method of hip joint evaluation on the same radiographs, it was found that fewer dogs on limited food intake had signs of hip dysplasia. Radiographs done when dogs were 2 years old, for all the methods used (Norberg angle in standard and frog-limb position, the Orthopedic Foundation for Animals [OFA] score, and the Swedish score), revealed less hip dysplasia (less joint subluxation and less degenerative joint disease) in the limit-fed dogs. Using the OFA method, 7 of the 24 limit-fed dogs and 16 of the 24 ad libitum-fed dogs were diagnosed as having hip dysplasia. Similarly, using the Swedish method, 5 of the 24 limit-fed dogs and 18 of the 24 ad libitum-fed dogs were diagnosed as having hip dysplasia. The food-intake-related differences were significant both for the OFA score and for the Swedish score.(ABSTRACT TRUNCATED AT 250 WORDS)

Animal Feed↗
PubMed1991

Some observations on the dietary vitamin D requirement of weanling pups.

A study was conducted to test the hypothesis that growing dogs do not require supplementation with cholecalciferol (vitamin D-3) in a nonpurified extruded diet. Twenty-eight weanling pups from four litters of English pointers and two litters of German Shepherd dogs were allotted equally to two groups by gender and weight. Dogs were raised in indoor-outdoor kennel runs for the 102-wk evaluation. One group was fed a diet that contained no added vitamin D while the other group was fed the same diet to which had been added 60.5 micrograms cholecalciferol/kg diet. Both diets contained approximately 14% calcium and 1.0% phosphorus. Growth as measured by body weight and length, serum calcium, phosphorus and alkaline phosphatase and urine hydroxyproline were not significantly different (P greater than 0.05) between the two treatment groups. There was no relationship between dietary treatment and nutritional secondary hyperparathyroidism (NSH), rickets or other skeletal abnormalities. The data support the concept that addition of vitamin D to typical commercial dog foods for purposes of prevention or amelioration of rickets, NSH or other skeletal diseases is unnecessary.

Alkaline Phosphatase↗
PubMed1991

Histopathologic features, environmental factors, and serum estrogen, progesterone, and prolactin values associated with ovarian phase and inflammatory uterine disease in cats.

Forty-four female American Shorthair cats with inflammatory uterine disease or infertility were evaluated. Data collected included age, month of diagnosis, housing, reproductive history, results of bacteriologic culture of uterine specimens, serum concentrations of estrogen, progesterone, and prolactin and histopathologic features of the ovaries and uterus. Histologically, the ovaries of 19 cats were dominated by active or cystic follicles, whereas 25 cats had luteal-phase ovaries. Of the 25 cats with active corpora lutea, 20 had either recently weaned litters (n = 11) without subsequent exposure to a male cat, or had been housed individually for lengthy periods (n = 9). The finding of active corpora lutea under these circumstances indicates that in queens, ovulation may occur by mechanisms not involving coitus. Prominent, active corpora lutea on the ovaries were associated with adenomatotic proliferative changes in the superficial and glandular epithelium of the uterus and with myometrial hyperplasia, compared with the uterus of cats with follicular ovaries (P less than 0.01). Serum progesterone concentration greater than or equal to 1.87 ng/ml was consistently associated with luteal-phase ovaries. Serum progesterone values less than or equal to 0.15 ng/ml were consistently associated with follicular-phase ovaries. Escherichia coli was the organism most commonly isolated from uterine contents.

Animals↗
PubMedDate not supplied

Evidence for genetic involvement in feline dilated cardiomyopathy.

Quantitative genetic evaluation of clinical dilated cardiomyopathy (DCM) was conducted in a large cattery with known history. Data showed that clinically affected cats were significantly more interrelated than randomly chosen case-control populations from the same colony. The results of this study suggest that quantitative inheritance, either interactive with or independent of nutrition or presently unknown factors, is involved in feline dilated cardiomyopathy.

Animals↗