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Biomedical subjects

K L Mossman

Publications and source records attributed to K L Mossman.

51 records · Page 3Linked to original sources
PubMed1982

Utility of interferons in clinical radiotherapy.

Interferons are being tested in the treatment of a wide range of malignancies. Clinical experience has indicated that interferons may have relatively few side effects compared to other commonly used antineoplastic agents. In addition, they have shown activity as radiation response modifiers in various experimental systems. Thus, as natural biological compounds, interferons may prove to be superior to other radiation response modifiers now on clinical trial in radiotherapy. In this paper radiation-interferon interactions are reviewed and the evaluation of the usefulness of interferons as an adjuvant in radiotherapy is discussed.

Animals↗
PubMed1982

Radiation risks in pregnancy.

A major contraindication of radiodiagnostic procedures is pregnancy. Approximately 1% of all pregnant women are given abdominal x-rays during the first trimester of pregnancy. Evaluation of radiation exposure should involve consideration of the types of examinations performed and when performed, as well as radiation dose and risk estimation. This information is then weighed against other possible risks of the pregnancy as well as personal factors. In the authors' experiences, radiation exposures usually result in doses to the embryo of less than 5 cGy (rad); the resulting radiation risks are usually small compared with other risks of pregnancy. Procedures to minimize diagnostic x-ray exposure of the fetus are also discussed.

Adolescent↗
PubMed1980

Accidental beta radiation burns from an electron accelerator.

A 61-year-old man presented to the emergency department after accidental exposure to beta radiation and low dose x radiation from an industrial linear electron accelerator. Over 40 days he developed burns on the extremities, abdomen, and face which eventually healed with topical silver sulfadiazine treatment, but suffered no acute x or gamma radiation symptoms. Beta burns and other radiation effects are discussed.

Administration, Topical↗
PubMed1977

The statistical distribution of colony counts in the spleen colony assay.

The statistical distribution of colony counts in the spleen colony assay was determined in C57BL/6 and C3H mice under varying conditions of the assay procedure. Assay mice were given syngeneic bone marrow cells from normal or irradiated donors. The mice were injected intravenously with marrow cells either immediately or 3 days after irradiation. Eight days after engraftment, spleen colonies were counted and the statistical distribution of colony counts was determined using a mean to variance ratio criterion. Analysis of the data indicated that the statistical distribution of colony counts was different in the two strains of mice. In addition, delaying time of injection of mice with bone marrow cells or injecting bone marrow cells form irradiated donors also changed the statistical distribution. The significance of this work lies in the fact that modification of the usual assay procedure can alter the statistical distribution of colony counts, thus changing the statistical accuracy of the assay. Modification in the assay procedure, such that an increase occurs in the variance of the distribution of colony counts, must be compensated for by increasing the number of spleens counted in order to maintain a constant level of statistical accuracy in experiments.

Animals↗
PubMedDate not supplied

Analysis of risk in computerized tomography and other diagnostic radiology procedures.

Medical practice entails continuous risks to the patient taken in good faith by the physician for the benefit of the patient. Risk of radiation induced cancer death approximates 10(-4) per cGy (rad). Assuming an average whole body dose of 0.1 cGy for many diagnostic X-ray procedures, the probability of radiation-induced cancer death is about 10(-5). The purpose of this paper is to compare the risks of common diagnostic X-ray procedures including computerized tomography (CT) with risks of smoking or automobile travel. Such comparisons should be constructive in putting radiation in perspective and facilitating explanation of risk/benefit to patients.

Accidents, Traffic↗