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Biomedical subjects

K L Parthasarathy

Publications and source records attributed to K L Parthasarathy.

25 records · Page 2Linked to original sources
PubMed1977

The value of liver scan in the follow-up study of patients with adenocarcinoma of the colon and rectum.

Seventy consecutive patients with adenocarcinoma of the colon and rectum had a liver scan followed by surgical exploration of the liver. Preoperatively, blood chemistry studies were done in addition to palpation of the abdomen. Surgical findings were correlated to results of the liver scans, function tests and palpation of the liver. The overall concordance of liver scans with surgical findings was 78 per cent. Thirty per cent had false-positive results and 15 per cent, false-negative results. The correlation of the liver scan with surgical findings was improved with increasing extent of metastases. When less than 25 per cent of the liver was replaced by tumor, there was a random correlation of scan to surgical findings. By combining liver scans and liver function tests, metastases could be predicted with increased reliability only in patients who had severe metastatic disease of the liver. It is strongly recommended that patients with liver scans suggestive of metastatic disease and with most liver function tests within normal limits undergo exploration to establish the diagnosis. Exploratory laparotomy seems to be the only way to avoid chemotherapeutic treatment of patients with false-positive scans and still allow detection and treatment of metastases to the liver to occur at earlier stages.

Adenocarcinoma↗
PubMed1975

Gallium-67-citrate scanning for the localization and staging of lymphomas.

One-hundred-eight 67Ga-citrate scans were evaluated in Hodgkin's and non-Hodgkin's lymphomas for staging, diagnosis of recurrence, and for determing the results of treatment. Accuracy as confirmed by comparing the scans with pathologic material or roentgenologic and clinical findings was found to be 83%. Known lymph node involvement was diagnosed correctly in 87% but accuracy was only 48% for extranodal areas. Bone lesions were diagnosed correctly in 83% compared with only 48% of lesions of the lungs and liver. Scans were 75% accurate in 28 patients scanned for initial staging. False negatives were present in 12%; recurrent tumor in an area of prior radiation therapy appeared to be the most common cause. There were 5% false positives. Gallium scanning is a useful adjunct to other methods of detecting lymphoma.

Adolescent↗
PubMed1975

An evaluation of 99mTc-sulfur colloid liver scintiscans and their usefulness in metastatic workup: a review of 1,424 studies.

To determine the clinical usefulness of liver scintiscanning in detecting metastatic disease of the liver, 1,424 liver studies performed on 1,115 patients were reviewed along with their charts. Five hundred eighty-one patients had histopathological evaluation by needle biopsy of the liver, laparotomy, and/or autopsy within a mean period of 40 days of liver scan. The histopatholigical findings were correlated with the liver sicntiscan findings and the latter gave an overall accuracy of 77.3%.

Brain Neoplasms↗