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Biomedical subjects

K L Rasmussen

Publications and source records attributed to K L Rasmussen.

At least 19 recordsLinked to original sources
PubMed2001

[Vaginal hysterectomy in non-prolapsed uterus].

AIM OF STUDY: To describe the results of vaginal removal of the non-prolapsed uterus in women conventionally operated on abdominally or with the assistance of laparoscopy. MATERIAL AND METHODS: At the departments of gynaecology, Herning Central Hospital and Holstebro Central Hospital, approximately one third of all hysterectomies are performed vaginally. All records of women, who had had a vaginal hysterectomy on a non-prolapsed uterus over a nineteen-month period, were reviewed retrospectively. Women, who had additional surgery, were excluded. RESULTS: One-hundred and thirteen patients entered. In one patient (1%) the vaginal hysterectomy was converted to an abdominal one. One fourth of the women had a uterus weighing more than 200 grams. The median operation time was 58 minutes; 73% bled less than 200 ml. Half of the women were discharged from hospital on the third postoperative day or earlier; 90% on the fifth postoperative day or earlier. During operation three accidental bladder lesions occurred, and four women needed an additional haemostatic operation. Postoperatively, 10 women (9%) suffered from a haematoma or an abscess in the vaginal vault. CONCLUSIONS: Vaginal hysterectomy on the non-prolapsed uterus is an operation that should be offered to a large group of women, who today are operated on abdominally or with laparoscopic assistance. The operation is quick and the patients are discharged after a few days. No advanced equipment is needed. Some women will, however, suffer from a haematoma in the vaginal vault.

Female↗
PubMed2001

[Circumcision].

Explore the source record for details and available documents.

Child↗
PubMed2001

Changes in yearling rhesus monkeys' relationships with their mothers after sibling birth.

The birth of a new sibling is believed to signify an abrupt and important transition in a young primate's relationship with its mother-one that is of potential importance from at least three theoretical perspectives: attachment theory, parent-offspring conflict theory, and dynamic assessment models. This study examines changes in relationships between free-ranging yearling rhesus monkeys (Macaca mulatta) and their mothers concomitant with the birth of the mother's next infant, and tests predictions derived from each theoretical perspective. We observed 31 yearling rhesus on Cayo Santiago, Puerto Rico, 3 months before and 3 months after their siblings' births, using focal animal sampling methods. Changes in measures related to mother-yearling interaction and yearling distress were examined using repeated-measures analysis of variance. After sibling birth, mothers and yearlings abruptly reduced amounts of time in contact and increased amounts of time at a distance and out of sight of one another. Mothers and yearlings played approximately equal roles in bringing about decreases in proximity, and yearlings took the primary roles in bringing about decreases in contact. Rates of maternal aggression toward yearlings increased immediately and markedly after birth, possibly providing yearlings with early cues regarding subsequent decreased levels of maternal care. There were no marked increases in overt signs of yearling distress (e.g., vocalizations or tantrums) following the births. We conclude that yearlings generally acquiesced to reduced levels of care, responding behaviorally with increased independence and maturity. In this sense, our study provides preliminary support for dynamic assessment models over attachment theory and parent-offspring conflict theory models.

Age Factors↗
PubMed2000

[Influence of fetal weight on outcome of prolonged pregnancy].

The aim of the study was to compare the influence of foetal weight on the outcome of a prolonged pregnancy. The study group consisted of all women delivered after a prolonged pregnancy at the Dept. of Obstetrics, Herning Central Hospital, during the period from 1.1.1993 to 31.3.1999, stratified by foetal weight. Five-hundred and eighty women were included. Women who gave birth to a child with birthweight less than 3.5 kg were more frequently given oxytocin infusions, and more children were transferred to the neonatal care unit. Heavy children weighing at least 4.5 kg were more frequently delivered by Cesarean section. In all groups very few children had low Apgar scores. When comparing the study population to a population of women giving birth after a completely normal pregnancy, significantly more grade 3-4 perineal ruptures and intrumental deliveries were found in the study group. In conclusion, foetal weight seems to be a poor predictor of the outcome after prolonged pregnancy. Prolonged pregnancy is associated with more instrumental deliveries and perineal ruptures.

Cesarean Section↗
PubMed2000

Interventions during labor in relation to height in obese women.

The aim of the study was to investigate, whether height is a predictor of interventions during labor in obese women. Therefore the relationship between height and interventions during labor was investigated in 661 obese women delivering a single child in vertex presentation. Diabetic mothers were excluded. As a result there was a trend towards more medical inductions in tall women, but without reaching statistical significance. No other differences were found. We conclude, that short stature is not a major predictor of interventions during labor in Danish, obese women.

Body Height↗
PubMed1999

[Cancer of the endometrium following radiotherapy of cervical cancer].

We describe three cases of women who have been treated with radiotherapy for cervical cancer and then many years later develop cancer of the uterine endometrium. Apparently there may be active endometrium left in the uterus after radiotherapy, for which reason we recommend combined hormone therapy with oestrogen and progesterone.

Adenocarcinoma↗
PubMed1999

[Premenopausal vulvar basocellular carcinoma].

A case of vulvar basocellular carcinoma in a 49-year-old woman is presented. The treatment of choice is local excision and the prognosis in general is excellent. The importance of taking biopsies from atypical vulvar lesions is underlined.

Basal Cell Carcinoma↗
PubMed1999

A preliminary description of responses of free-ranging rhesus monkeys to brief capture experiences: behavior, endocrine, immune, and health relationships.

A cohort of free-ranging rhesus monkeys has been followed since birth in 1994 on the island of Cayo Santiago, Puerto Rico. At 3 years of age, subjects were trapped and blood samples were collected after capture and prior to release the following day. Blood samples were processed for natural cytotoxicity toward xenogeneic tumors, phenotyping, and plasma hormones. Intestinal parasites were determined from fresh stool samples collected during trapping. Data were also available from the previous year for antibody titers to latent viruses prevalent in this population. Behavioral traits of each monkey were characterized using a previously developed trait scale for rhesus monkeys. Natural cytotoxicity toward both K562 and Raji targets declined from capture until release the following day. Plasma cortisol rose and plasma prolactin and growth hormone fell during the period of captivity; a rise in insulin was significant. It was expected that individual differences in behavioral traits might predict immune and hormone levels at the time of capture or changes in these parameters during the capture period. Although behavioral adjectives tended to cluster along three orthogonal dimensions (Insecurity, Irritability, and Sociability), they bore no relationship to the physiological parameters collected acutely (in vitro immune and endocrine parameters). The individual difference markers of gender and maternal rank were not related to the magnitude of the observed changes in these in vitro parameters, either. However, an in vivo measure (CMV titer) was related to individual differences in Irritability. It was concluded that the magnitude of the stress associated with capture overwhelmed the individual difference effects.

Animals↗
PubMed1999

The influence of prepregnancy body mass index on labor complications.

BACKGROUND: To investigate the influence of Body Mass Index on the incidence of labor complications in a population of women with a normal pregnancy. MATERIAL AND METHODS: From a local database, information on maternal weight and height was extracted concerning 4258 women who had an uncomplicated pregnancy. After calculation and stratification with respect to Body Mass Index, this was retrospectively related to labor interventions and complications. RESULTS: High Body Mass Index was related to more oxytocin infusion and early amniotomy, but not to vacuum extraction or cesarean section. Primary inertia and, to a minor degree, cephalopelvic disproportion and secondary inertia were seen more often in women with high Body Mass Index. CONCLUSIONS: Overweight (25.0<=BMI<30.0) and obesity (BMI>=30.0) are only weak predictors of labor complications, given a normal pregnancy. However, the heavy use of labor augmentation indicates that obese women should not be recommended to give birth in an ABC-clinic or at home.

Body Mass Index↗
PubMed1998

[Delivery of extremely large infants].

The purpose of this retrospective study was to find out if more effort should be applied to the diagnosis of extremely large infants, with a birth weight of 5,000 grams or more, and if elective caesarean section can be recommended. In the Department of Obstetrics, Herning Central Hospital, Denmark, 67 mothers delivered an infant with a birth weight of 5000 g or more over a ten year period. This index group was compared with a matched group with infants of normal weight. The result showed significantly more caesarean sections in the index group (24% versus 5%, p = 0.002). Shoulder dystocia and Duchenne-Erb's palsy were more frequent as well. Sixteen percent in the index group were admitted to the paediatric department, but the Apgar scores were not significantly lower. Except for one, all the infants showed complete recovery. In conclusion, elective caesarean section can not be generally recommended for an estimated birthweight exceeding 5,000 g, if a trained obstetrician is present at delivery.

Apgar Score↗
PubMed1998

Histocompatibility antigen studies in women with recurrent miscarriages and Müllerian uterine anomalies.

OBJECTIVE: To determine whether the HLA alleles DR1, DR3, DR4 and DR10 which have been suggested to be risk markers for unexplained recurrent miscarriages also play a part in women with recurrent miscarriages with Müllerian uterine fusion anomalies. STUDY DESIGN: HLA-DR typing was undertaken in 28 women with recurrent miscarriage who had been surgically treated for Müllerian anomalies and in 360 controls. In the study group, outcome of pregnancies after surgery was correlated to the results of the HLA typing. RESULTS: In the study group, 61% were positive for HLA-DR1, -DR3, -DR4 or -DR10 compared with 65% of the controls (not significantly different). Among patients positive for these HLA risk markers, 64% of the pregnancies after surgery miscarried compared with 13% in those negative (P<0.005, RR for miscarriage=4.8, 95% CI= 1.3-18.0). CONCLUSION: The proposed risk HLA markers for unexplained recurrent miscarriage also seem to display a negative impact on pregnancy outcome in patients with recurrent miscarriages with Müllerian uterine anomalies.

Abortion, Habitual↗
PubMed1997

[Habitual abortion. A review of etiology, diagnosis and treatment with emphasis on immunonological factors].

Almost 1% of women who attempt pregnancy will experience recurrent miscarriage. The majority of traditionally accepted causes of recurrent miscarriage lack proper documentation and the evidence for the majority of treatments is sparse. An increased level of midfollicular phase luteinizing hormone seems to be associated with some cases of recurrent miscarriage. Many autoantibodies are found with increased frequency in women with recurrent miscarriage, and they seem to be associated with an increased risk of adverse pregnancy outcome. This may indicate that the autoantibodies per se or associated immunological phenomena are risk factors for the condition. Polygenically determined immunological phenomena seem to play an important role. Treatment of recurrent miscarriage by anticoagulation, allogeneic lymphocyte immunization or intravenous immunoglobulin is under evaluation in controlled trials.

Abortion, Habitual↗