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Biomedical subjects

K L Stevens

Publications and source records attributed to K L Stevens.

8 recordsLinked to original sources

The treatment of pleomorphic adenomas by formal parotidectomy.

We reviewed 100 patients who underwent formal parotidectomy. Seventy-two were new patients in whom a parotid lump proved to be a pleomorphic adenoma. Twenty-eight were patients in whom a tumour had recurred after treatment for pleomorphic adenoma by local excision (with or without irradiation) elsewhere. After a follow-up of 1--15 years (median 4 years), there were no recurrences in the primary group but 5 recurrences among the secondary cases. Permanent facial nerve damage was not seen in the primary group, but 11 patients undergoing secondary parotidectomy were left with some permanent facial weakness. Malignant change occurred in 4 patients in the secondary group.

Adenoma, Pleomorphic↗

Repin, a sesquiterpene lactone from Acroptilon repens possessing exceptional biological activity.

Consumption of Russian knapweed (Acroptilon repens) by horses results in the necrosis of neural cells in the substantia nigra. Repin, one of the sesquiterpene lactones found in Russian knapweed, has been shown to possess high toxicity toward chick embryo sensory neurons. The possible causal relationship between repin and equine nigropallidial encephalomacia disease prompted a more complete structural assignment of repin, which was accomplished by X-ray and 1H-nmr analyses.

Animals↗