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K Landwehr

Publications and source records attributed to K Landwehr.

2 recordsLinked to original sources

Optical magnification as event information.

The geometrical optics of approach events is delineated. It is shown that optical magnification provides information about distance and time until collision. An experiment is described in which two objects--white styropor spheres 10 cm in diameter, seen against a white plaster wall--were moved simultaneously at equal, constant speed along straight, converging paths at eye level towards a human observer and towards a common, virtual point of collision which either coincided with the observer's station point or was placed in front of, or behind, that point. Approach events differed with regard to trajectories, distances, velocities, and times-to-collision involved. Events were observed monocularly fixating and binocularly non-fixating, without head movements. The objects always stopped before colliding, and subjects had to respond to the virtual collisions. Most responses were too early, especially for impending collisions at, or behind the observers' station point. Responses for impending collisions in front of the observers tended to be too late, especially for larger total amounts of optical magnification and higher velocities, which together imply shorter times-to-collision. Relative errors were comparatively larger for very short and very long times-to-collision throughout, where events of the first kind were overshot, the latter ones undershot. Results are interpreted with reference to biological theories and the constraints imposed by geometrical optics. Special attention is focused on the issue of unavoidable, necessary confounding of variables in time-to-collision studies.

Acceleration↗

Activity of phospholipase A2 in plasma increases in uremia.

We measured phospholipase A2 (PLA2; EC 3.1.1.4) activity in normal and uremic plasma, using [1-14C]oleate-labeled autoclaved Escherichia coli as substrate. Hydrolysis of bacterial phospholipid by crude plasma from both groups was optimal at pH 5.5, was specific for the 2-acyl position of phospholipids, and had an absolute requirement for calcium. Activity was greatest in the presence of added Ca2+, 5 mmol/L, but this increase was inhibited by several divalent cations (Mg2+, Zn2+, Cu2+, Ba2+, Co2+, Pb2+, Fe2+) and by Fe3+. PLA2 activity was also inhibited by heparin at acid and alkaline pH, normal plasma being more sensitive than uremic plasma to this inhibition. Enzyme activity in undiluted plasma was eightfold greater in uremic than in normal plasma. Dilution of plasma by two to fourfold increased the total activity of both normal and uremic plasma. However, the relative differences in total activity between the groups remained constant (eight- to 11-fold). The cause and consequences of the increased PLA2 activity in uremia remain to be established.

Calcium Chloride↗