PubMed Health⌕ Search

Biomedical subjects

K Lauritsen

Publications and source records attributed to K Lauritsen.

108 records · Page 6Linked to original sources
PubMed1983

Arthritis in patients with antimitochondrial antibodies.

We describe the clinical and radiographic findings in 15 women with antimitochondrial antibodies (AMA) without clinical liver disease. Arthralgias appeared in their third or fourth decade and typically involved the small joints of the hands with periarticular swelling and cortical erosions. Few hand nodes, deformation, or sclerodactyly. Four had histologic primary biliary cirrhosis (PBC). The association between arthritis and PBC is discussed. The arthritis and PBC may be two manifestations of some general underlying disease process, AMA being a marker. Patients with atypical arthralgias affecting the hands should have the AMA test performed in view of the possibility that this affection might accompany or progress to PBC.

Adult↗
PubMed1983

Gastrin production following antrectomy. A study on the occurrence of gastrin-producing cells and the serum gastrin response to feeding.

Fifteen patients were studied 3 to 35 years after antrectomy, with a gastroduodenal (Billroth I (BI)) anastomosis in 8, and a gastrojejunal (Billroth II (BII)) anastomosis in 7. The investigations included gastric acid secretion, serum gastrin response to feeding and immunohistochemical search for gastrin-producing cells in gastric remnant mucosal biopsies. All of the patients had hypochlorhydria. The gastrin response to feeding was minimal. Apart from a significantly higher value of serum gastrin 3 hours post-prandial in BI operated as compared to BII operated patients, no greater differences were found in the gastrin production between the two groups of patients. No gastrin-producing cells could be identified in the gastric remnant, not even in areas of pseudopyloric metaplasia. It is concluded that the gastrin production following antrectomy is caused by extragastric G-cells; these cells are poorly stimulated by food, and do not respond to hypochlorhydria with hypergastrinaemia.

Aged↗
PubMed1981

Secretin release from the isolated, vascularly perfused pig duodenum.

1. A method for the isolation and vascular perfusion of the porcine pancreas and duodenum was developed. 2. The oxygen consumption of the whole preparation was similar to that of the pancreas alone, and since the duodenal arteriovenous oxygen deficit was similar to that of the total preparation, it was concluded that the duodenum respired adequately. 3. The duodenum rapidly absorbed luminally administered radioactive glucose, and this absorption was strongly inhibited by ouabain and phloridzin. 4. The duodenum secreted secretin rapidly in response to hydrochloric acid, but did not respond to any other luminal stimuli, including lipids, proteins, carbohydrates and bile. Neither was secretin release stimulated by intra-arterially injected acetylcholine. 5. By gel permeation chromatography the release immunoreactive secretin behaved identically to pure natural secretin, indicating that the tissue form and the circulating form have identical molecular size. 6. It is concluded that this model offers an unique opportunity to study the endocrine secretion of the duodenum.

Animals↗
PubMed1981

The human stomach after antrectomy. A study of the type of epithelium, occurrence of gastrin-producing cells, and basal serum gastrin.

A histological and immunohistological investigation was performed on biopsy specimens from ten patients 3 to 35 years after antrectomy, to study the type of epithelium and the possible occurrence of gastrin-producing cells (G cells) in the distal stump of the stomach remnant. The study showed that parietal cells were present in all patients, whereas G cells could not be demonstrated, although areas of pyloric-type epithelium (pseudopyloric metaplasia, were seen in eight. We conclude that the pyloric-type metaplasia, which occurs in the fundic mucosa after antrectomy, does not involve the G cells. It is suggested that the normal levels of fasting serum gastrin in these patients originate from outside the gastric mucosa, presumably from the duodenal bulb.

Adenocarcinoma↗
PubMed1981

The antral gastrin-producing cells in duodenal ulcer patients. Study of the relationship between G-cell density, gastric acid secretion and fasting serum-gastrin.

Examination of the antral G-cell density, acid secretion and fasting levels of serum-gastrin were carried out on 20 patients with prepyloric ulcer (within 2 cm of the pyloric ring) and 76 patients with duodenal bulb ulcer. No difference was found in respect to the G-cell density between the group of prepyloric and that with duodenal bulb ulcer, although a lower pentagastrin stimulated acid output and consequently a smaller parietal cell mass appeared to be present in the first group as compared to the second. No relationship was found in either group between fasting levels of serum-gastrin and G-cell density, suggesting that no constant relationship exists between G-cell density and activity under basal conditions. A positive relationship, although statistically insignificant (0.05 less than P less than 0.1) between peak acid output and G-cell density in patients with duodenal bulb ulcer, indicates that in these patients the parietal cell mass and G-cell density are interrelated. The present study could not confirm the entity of antral G-cell hyperplasia in duodenal ulcer patients.

Adult↗
PubMed1979

Fat-induced jejunal inhibition of gastric acid secretion and release of pancreatic glucagon, enteroglucagon, gastric inhibitory polypeptide, and vasoactive intestinal polypeptide in man.

The effect of intrajejunal (i.j.) infusion of fat on meal-stimulated gastric acid secretion and release of pancreatic glucagon (PG), enteroglucagon (EG), gastric inhibitory polypeptide (GIP), and vasoactive intestinal polypeptide (VIP) was studied in seven healthy volunteers. I.j. fat markedly inhibited meal-stimulated acid secretion as compared to a control study with i.j. saline infusion. The acid inhibition was accompanied by augmental plasma concentrations of EG, GIP, and VIP but not of PG, suggesting that EG, GIP, and VIP may be among mediators of fat-induced jejunal inhibition of acid secretion. Concentration-time relationship makes it unlikely that the observed inhibition could be ascribed to any single peptide studied.

Adult↗
PubMed1975

Volvulus of the colon.

The results of treatment for volvulus of the colon during 13 years in a community hospital are analysed, It is concluded that sigmoid volvulus should be treated with proctoscopic examination and insertion of a rectal tube, unless signs of gangreana or peritonitis are present. In patients without accompanying sever diseases, elective resection should be performed later. Repeated tube decompressions should be attempted in patients with recurrence and high operative risk. Unsuccessful tube decompressions or signs of a non-viable colon should be followed by emergence laparotomy and, probably, resection of the sigmoid colon whether gangraena is present or not. Volvulus of the cecum should be treated with operative reduction and pexia or cecostomy, unless gangreana necessitating a hemicolectomy is present.

Aged↗