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Biomedical subjects

K Leksowski

Publications and source records attributed to K Leksowski.

13 recordsLinked to original sources
PubMed2006

Ondansetron, metoclopramid, dexamethason, and their combinations compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy: a prospective randomized study.

BACKGROUND: A prospective randomized study was performed to assess the value of some individual risk factors for postoperative nausea and vomiting (PONV), and to compare the efficacy of ondansetron, metoclopramide, dexamethason, and combinations of these antiemetics in preventing PONV in patients after laparoscopic cholecystectomy. METHODS: The study enrolled 210 patients (157 women and 53 men) scheduled for laparoscopic cholecystectomy. The patients were randomly divided into seven groups. In groups 1 to 6, antiemetic drugs were administered. Group 7, the control group, received no antiemetic. For all the patients, individual risk factors for the incidence of nausea also were analyzed. Both nausea and vomiting were assessed separately 1, 4, 8, and 12 h after the procedure. RESULTS: Postoperative nausea and vomiting were significantly less frequent in menopausal women and more frequent in patients with a history of motion sickness. A comparison of mean values for the incidence of nausea and vomiting in groups 1 to 6 with the same values in group 7 showed that the mean PONV incidences were highest in groups 3 and 7, and the difference was significant. CONCLUSIONS: Administration of antiemetic drugs significantly decreases the incidence of PONV in patients after laparoscopic cholecystectomy. The best decreases were achieved when ondansetron and dexamethason were applied together.

Adult↗
PubMed2001

Thoracoscopic splanchnicectomy for the relief of pain due to chronic pancreatitis.

BACKGROUND: Many methods have been advocated for control of pain in patients suffering from chronic pancreatitis. Some patients may be considered for pancreatic denervation. This study was performed to evaluate the effect of thoracoscopic splanchnicetomy (TS) on pain intensity and many of the common daily functions in patients with intractable pain due to chronic pancreatitis. METHODS: Twenty-four thoracoscopic splanchnicectomies were performed on twenty patients. To assess pain severity and the impact of the pain, all patients completed short form using 0-10 numeric rating scale. To describe and compare the adequacy of analgesic management before and after TS the Pain Management index was used. Patients were evaluated one day prior to the operation and on monthly basis for 6 months after the procedure. RESULTS: Pain was reduced after the operation significantly (p <0,001) and all but four patients had consistent pain relief during the postoperative follow-up. Four patients had recurrence of pain 3 months after left- sided TS; after undergoing TS on the opposite side, they were relieved of pain. The degree to which pain interfered common daily functions decreased significantly (p < 0,001) after surgery, and the adequacy of the analgesic management improved. CONCLUSIONS: Thoracoscopic splanchnicectomy is a simple, minimally invasive, save procedure that appears to offer relief from pain, allow recovery of daily activities and improve the adequacy of the analgesic management.

Abdominal Pain↗
PubMed2001

Thoracoscopic splanchnicectomy for control of intractable pain due to advanced pancreatic cancer.

BACKGROUND: Severe upper abdominal pain is a dominant and distressing feature of advanced pancreatic cancer. This study was performed to evaluate pain intensity and to determine the ways in which pain may interfere with the common daily activities of patients with intractable pain before and after thoracoscopic splanchnicectomy. METHODS: Twenty-six left-sided thoracoscopic splanchnicectomies were performed. To assess pain severity and the impact of pain, all patients completed a short questionnaire using the 0-10 Numeric Rating Scale. The Pain Management Index was used to describe and compare the adequacy of analgesic management. Patients were evaluated 1 day prior to operation and for 6 months after the procedure. RESULTS: Pain was reduced significantly after the operation (p < 0.001), and all patients enjoyed consistent pain relief during the postoperative follow-up. The degree to which pain interfered with their daily function decreased significantly (p < 0.001) after surgery. The adequacy of the analgesic management improved, and none of the patients required opioids. CONCLUSIONS: Unilateral left thoracoscopic splanchnicectomy is a simple, minimally invasive, effective, and safe procedure that can be recommended as the method of choice for the management of intractable upper abdominal pain due to advanced pancreatic cancer.

Adult↗
PubMed2001

[Evaluation of efficacy of selected antiseptics for hands disinfection before surgical procedures].

The most important in surgical hands washing and disinfections is long-term and effective reduction of bacteria number. The aim of this study was to compare the efficiency of some antiseptic fluids used for surgical hands disinfection's (AHD 2000, Biotensid, Manopronto and Medi-Scrub PVP Iodine). 62 doctors and surgical nurses were examined. The material for the bacteriological examination was collected before and after hands disinfection's. The bacterial flora reduction have been presented as a percent and a logarithmic reduction ratio. All estimated antiseptic fluids were very potent and provided prolonged efficiency when the operation team complied with orders of hands washing.

Anti-Infective Agents, Local↗
PubMed1991

[Heart injury caused by air shock wave trauma].

The aim of the study was the estimation of heart muscle in response to air shock wave trauma. The animals were divided into four groups according to the time between trauma and the examination (3, 24, 48 and 120 hours). In all groups of animals ecg was performed and plasma level of creatinine kinase (CK), cardiac isoenzymes (CK-MB), lactic dehydrogenase (LDH) and its isoenzymes (LDH1-2) and alpha hydroxybutyrate dehydrogenase (HBDH) were determined. CK-MB activity as a percent of CK activity and rate of LDH isoenzymes activity were calculated. Morphologic estimation of heart injury based on macroscopic observation, histology and coronarography of heart specimens was performed. It was revealed that pathologic changes in ecg indicating intracardial conduction disturbances occur most intensively in first ten minutes after trauma. Plasma CPK, LDH and LDH1-2 activity increased significantly after 120 hrs following trauma. Morphologic manifestation of heart damage was multifocal injury of heart muscle.

Animals↗
PubMedDate not supplied

[Creation of arterio-venous fistulas in patients chronically treated with hemodialysis].

The authors present a 5-year experience in formation of the arterio-venous fistulas for hemodialysis. Analysed material includes 58 fistulas in 40 patients. Fistulas were formed twice or more times in 22% of the patients. Thrombus in the fistula was the most frequent complication (10.3%). The authors form arterio-venous fistula "of choice" in the peripheral portion of the forearm anastomosing radial artery with cephalic vein "side-to-end". Such a procedure in other portions of the arm is related to a higher risk of failure. Intra-arterial subtraction angiography is of significant help in the selection of the tactics of secondary operations forming fistula.

Adult↗