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Biomedical subjects

K Licorish

Publications and source records attributed to K Licorish.

7 recordsLinked to original sources
PubMed1986

Serum ferritin in acquired immune deficiency syndrome.

Ferritin has been linked to a variety of immunosuppressive effects on cell-mediated immunity. Therefore, serum ferritin was measured by radioimmunoassay in patients with acquired immune deficiency syndrome (AIDS), AIDS-related complex (ARC) and healthy heterosexual men. 13 of 15 patients with AIDS and 4 of 15 with ARC had ferritin levels greater than 300 micrograms/dl. This study suggests that the levels of serum ferritin increase with the progression of immune deficiency and might play a role in the pathogenesis of cell-mediated immune deficiency in AIDS.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Role of Alternaria and Penicillium spores in the pathogenesis of asthma.

The ability to harvest spore-rich isolates of molds permitted quantitative studies of their role in the pathogenesis of asthma. Alternaria and Penicillium were selected as examples of ubiquitous molds that readily induce IgE antibodies and are of contrasting sizes. Extracts from those spores were prepared for skin tests and aerosol bronchial challenges. Intact spores were used in the same subjects in bronchial challenges delivered by a Spinhaler. Seven patients with a history of mild asthma received a total of 16 bronchial challenges with the mold to which they had been sensitized. Provocative doses in spore equivalents for a 35% drop in SGaw, 20% drop in FEV1, or 25% drop in PEFR were sought for each challenge. Density dependence-flow rates were also determined. Environmental spore survey data were obtained and compared with the challenge doses for these spores. It was found that immediate-type asthma was readily provoked by both whole spores and by their extracts, in some subjects fewer intact than extracted spores were required, delayed-type asthma occurred only after whole spore challenges, SGaw was the most sensitive and equally specific of the pulmonary function tests, and provocative doses of spore equivalents were within natural exposure ranges. The study confirmed that Alternaria and Penicillium spores in relatively natural states and numbers were potent immunopathogens for asthma.

Adolescent↗
PubMed1985

Spectrum of renal abnormalities in acquired immune-deficiency syndrome.

Data from 27 patients with acquired immunedeficiency syndrome (AIDS) and AIDS-related complex (ARC) managed at the University of California, Irvine Medical Center since 1982 were extracted from medical records. Functional renal insufficiency occurred with considerable frequency among the AIDS patients. In contrast renal function was stable in the ARC patients studied. The majority of the AIDS patients exhibited persistent or transient proteinuria. Hematuria, leukocyturia, bacteruria, and nonvenereal urinary tract infections were seen with considerable frequency among AIDS patients and much less frequently among ARC patients. Similarly various disorders of fluids, electrolytes, acid base and abnormal phosphorus and calcium levels were common among AIDS patients and uncommon among ARC patients. These observations point to the prevalence and significance of the renal and associated abnormalities in acquired immune-deficiency syndrome.

Acquired Immunodeficiency Syndrome↗
PubMed1984

Focal renal cortical necrosis associated with zomepirac.

Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache. Although renal function showed gradual improvement after seven days of anuria, the recovery was slow and incomplete. Renal biopsy three weeks after the onset of renal failure revealed evidence of focal renal cortical necrosis. Association of zomepirac administration with renal cortical necrosis is not known to have been previously demonstrated. This observation adds another dimension to the previously reported renal complications of nonsteroidal anti-inflammatory agents, especially zomepirac. The proportions of lymphocyte subsets, as defined with monoclonal antibodies, and the proliferative response to mitogens were normal. The patient's lymphocytes showed no proliferative response to zomepirac. Serum complement components and immunoglobulin levels were within normal limits, and radioallergosorbent testing gave negative results. The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.

Analgesics↗