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Biomedical subjects

K Lindner

Publications and source records attributed to K Lindner.

At least 37 records · Page 2Linked to original sources
PubMed1991

An approach to a synopsis of EEG parameters, morphology of brain convolutions and mental activities.

A method for the projection of EEG data on the brain surface is proposed. The EEG data are obtained during the performance of mental tasks and represented as probability maps of power and coherence changes with respect to the averaged EEG at rest. The morphological data are obtained from 3D reconstructions of the brain by means of serial slices provided by an MRI scanner. Before scanning the positions of the EEG electrodes were marked by dummy electrodes of plexiglass filled with a contrast medium. Changes of power are color-coded and entered at the respective electrode positions, changes of coherence between the respective positions. The applicability of this procedure in the fields of psychology, psychiatry and neurology is discussed.

Adult↗
PubMed1990

[The determination of suitable film-screen cassette combinations for orthodontic x-ray technics].

16 film-screen cassette combinations (FSCC) were compared with regard to their detail sharpness and the radiation dose required. After standard adjustment to a uniform average optical density, the contrast and detail were analysed using a self-constructed microdensitometer. The following results were found; on average there is a 14.5% dose reduction using carbon fiber cassettes compared with aluminium cassettes. FSCC with especially low exposure time are: Cronex 2, fast detail, Du Pont (0.4 sec); Cronex 2, NPU, carbon fiber cassettes (0.5 sec); Curix RP1, NPU, carbon fiber cassettes (0.64 sec). The loss of quality associated with this and measured with the microdensitometer is insignificant for clinical orthodontic purposes. This study concludes that differences in contrast and detail do not justify the use of cassette combinations which require a high dose of radiation.

Evaluation Studies as Topic↗
PubMed1990

[Drug exanthema due to chloral hydrate].

We report on a female patient with drug eruption due to Sirupus Chlorali hydrati SR. The causal allergen was chloral hydrate itself. This could be identified even by patch test and oral provocation test.

Adult↗
PubMed1990

High resolution multi-temperature sensors for biomedical application.

A temperature sensor array was designed in order to study local temperature variations and temperature gradients in biological samples. The sensor probe was inserted in the optical cortex of rabbits in order to study temperature changes during normal brain activity as well as under artificial ventilation conditions. Temperature sensitive areas of 0.14 mm x 0.1 mm are arranged in a row with interdistances of 0.4 mm yielding high spatial resolution. A temperature resolution of 0.1 mK and a 90% response time of maximum 3 milliseconds was obtained utilizing the high temperature dependence of 2%/K of the conductivity of vacuum evaporated germanium films. The sensor is passivated by a 1 micron thick PECVD-silicon nitride layer and can be placed on glass-, alumina- and polymer substrates. For brain tissue studies, in order to minimize tissue damage the temperature sensors were placed on a 0.1 mm thick needle-shaped glass substrate. A sensor element mounted on a glass substrate and immersed in water showed a self heating of less than 5 mK due to the applied measurement current of 2.1 microA.

Animals↗
PubMed1990

[Hemodynamic and clinical results following percutaneous aortic valve valvuloplasty in adults].

We analyzed the results and the follow-up in our first 80 patients after percutaneous balloon aortic valvuloplasty (BAV) since November 1986. Mean age was 74 +/- 10 years, 78 patients were in the NYHA functional classes III or IV. Initially we used relatively small balloons (15-18 mm), later balloons of 20 mm and, with increasing frequency, of 23 mm diameter were utilized, providing very strong inflations at the end of the procedure. The average valve area after BAV increased from initially 0.75 +/- 0.18 to 0.87 +/- 0.28 cm2 after July 1987. Using the 23-mm balloon a mean valve area of 1.05 +/- 0.19 cm2 was obtained. The procedure-related mortality was 2.5%, the total early mortality (30 days) was 6.25%. Other non-fatal complications included two cases of severe valve incompetence requiring valve replacement, one dissection in the aortic root, one cerebrovascular accident, and eight cases of arterial damage (surgical repair). Twenty-six patients with initially successful dilation were restudied hemodynamically, 12 of whom had a restenosis (46%) after 5 months; 13 patients had a second dilatation. The clinical improvement was remarkable (at least 1 NYHA functional class) in 79% of the patients. 33% were improved 1 year and 20% 18 months after the first or eventually the second BAV. Eighteen of the discharged patients died in the follow-up period (two after valve replacement); 20 patients had aortic valve replacement due to restenosis. Our results show a correlation of the maximal balloon size to the valve area after BAV. However, even a perfect technique cannot prevent the restenosis that occurs mostly during the first year. Therefore, BAV may be useful and appropriate for selected patients with inoperable aortic stenosis, but it is no alternative to valve replacement.

Aged↗
PubMed1986

The evolution of a hospital library patient education literature program.

The library staff of the Englewood Hospital Medical Library has developed a patient education literature program to meet the needs of patients and the public for health information. A subcommittee on patient education of the Medical Library Committee oversees the project. Lists of health resources, by subject, have been compiled and are available on nursing stations and in patient waiting areas. Materials are delivered by doctors, nurse clinicians or librarians (at a doctor's request) and documented in the nurse's notes. Community members are also encouraged to come into the library by appointment to seek answers to their health questions.

Hospital Bed Capacity, 500 and over↗
PubMed1984

Three-dimensional structure of fungal proteinase K reveals similarity to bacterial subtilisin.

The three-dimensional structure of the fungal serine protease proteinase K has been determined at 3.3 A resolution by single crystal X-ray diffraction analysis. The enzyme crystallizes in the tetragonal space group P4(3)2(1)2 with cell constants a = b = 68.3 A, c = 108.5 A. The asymmetric unit consists of one monomer of 27 000 daltons mol. wt., approximately 50% higher than the so far assumed value of 18 500 daltons. The main chain fold of proteinase K shows a high degree of tertiary homology with the corresponding bacterial subtilisin BPN'. Proteinase K is the second enzyme in this family of serine proteases to be studied by X-ray diffraction, thus confirming the existence of two unrelated families of serine proteases in pro-and eukaryotes.

Bacteria↗
PubMed1983

Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study.

dApT, a modified deoxyribose dinucleoside phosphate with an uncharged methylphosphonate group, crystallizes as dihydrate in space group P2(1)2(1)2, a = 9.629(3), b = 20.884(6) and c = 14.173(4)A, Z = 4. The structure has been determined using 2176 X-ray diffractometer reflections and refined to a final R of 0.105. Torsion angles about P-O(5') and P-O(3') bonds are -91.8 degrees and 117.8 degrees. The former is in the normal (-)gauche range while the latter is eclipsed. Bases are oriented anti, the sugar of adenosine is puckered 2T3 (C(2')endo) whereas that of thymidine displays puckering disorder with major and minor occupancy sites. Major site is a half-chair 2T (C(2')endo-C(1')exo) and minor site an envelope 3T2 (C(3(1)endo). Adenine and thymine bases of symmetry related molecules form reversed Hoogsteen type base pairs, water molecules are disordered in the crystal lattice.

Crystallography↗
PubMed1983

[Coagulation disorders in acute cranio-cerebral injuries].

Marked coagulation defects which have a very high mortality rate can arise following acute head injury. Damage to brain tissue leads to the release of substances promoting coagulation which can enter the vascular system and activate the enzyme cascade leading to clot formation. The more widespread cerebral damage is, the greater is the likelihood of clinically relevant DIC occurring. By carrying out clotting tests and taking therapeutic measures where necessary, a potentially lethal outcome can be avoided.

Acute Disease↗
PubMed1978

[Animal experiments on the question of healing around the Tübingen immediate implant].

In order to determine the capacity for deposition of bone, 5 Beagles were each implanted extraorally with 6 aluminium oxide cylinders into the horizontal mandibular ramus. 4 months after the first implantation a second implantation was carried out in the opposite side with similar cylinders. After six months all were removed so that in altogether 60 implants the bone deposition could be observed 4 months and 2 months after implantation. A further 14 dogs received altogether 55 Tuebinger immediate implants. All animals were regularly observed post-operatively. After 6 months all cylinder full-implants had been accepted without reaction. All tooth implants which were either not put under strain or were immediately put under pressure healed without reaction. After three months 19 implants were lost and a further 5 were lost after 8 months. All cylinder implants were histologically examined 6 months after first implantation.

Animals↗
PubMed1978

[Light and scanning electronmicroscopic studies of border surfaces of aluminum oxide-ceramic implants in the dog mandible].

The mandibular bone of beagles as well as foxhounds and the border surfaces in the area of implants of dense Al2O3 ceramic were examined by scan electron microscope and optically in undecalcified preparations 4 and 6 months after the start of the experiment. All implants healed without foreign body or inflammatory reaction and exhibited a firm contact with the newly-formed surrounding osseous tissue. The border surface was always formed by osseous tissue and bone marrow and not by connective tissue. The bony border surface presented a casting of the structure proper of the ceramics as well as orderly remodelling. The tooth implants which had in part been under strain for a long time were surrounded by newly formed osteoid bone and supported by bone trabeculi. In the immediate proximity of the surface of the ceramic vital osteophites were found. The gum which was placed in a groove of the step implants showed firm epithelial covering and orderly fibrous texture.

Aluminum Oxide↗