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K Lindvig

Publications and source records attributed to K Lindvig.

7 recordsLinked to original sources
PubMed1990

The pattern of cancer in a large cohort of stroke patients.

A cohort of 113,732 stroke patients from Danish Hospital Discharge Registry were, by linkage to the Danish Cancer Registry, found to have developed a total of 5151 cases of cancer in a mean follow-up time of 2.4 years after the diagnosis of stroke. There was no excess of gastric cancer. The present findings fail to support the existence of a common, strong risk factor for stroke and gastric cancer in individuals. In the cohort, more cancer than expected was observed. In particular, a more than ten-fold increase in risk of brain tumours within the first year after stroke diagnosis was observed, suggesting some diagnostic misinterpretation of a brain tumour as a stroke. Minor excesses of cancer of other sites were also found in the first year of follow-up. They are probably due to increased medical surveillance and diagnostic misinterpretation of an underlying malignancy as an incident of cerebrovascular disease, eg through metastatic spread to the brain.

Aged↗
PubMed1990

Echocardiographic screening in 24 consecutive AIDS patients.

To assess the prevalence and extent of cardiac abnormalities in patients with newly diagnosed AIDS, 24 consecutive patients admitted for treatment for acute opportunistic infections were examined with echocardiography during hospitalisation. None of the patients had known cardiac disease or were drug abusers. A total of 16 abnormalities were identified in 13 patients (54%). Nine patients had a right ventricular diameter exceeding 26 mm, two patients had a slightly dilated left atrium or left ventricle, respectively, and five had a moderate pericardial effusion (range 2-8 mm). Left ventricular contractility was normal in all patients. Survival rates between AIDS patients with or without cardiac abnormalities were identical. It is concluded that minor cardiac abnormalities are common in AIDS patients with acute opportunistic infection. However, echocardiography in this group of AIDS patients without cardiac complaints gives no important functional or prognostic information as a routine procedure.

Acquired Immunodeficiency Syndrome↗
PubMed1989

Cancer occurrence in a cohort of patients treated with cimetidine.

The possible carcinogenic effects of antisecretory agents used in the treatment of gastric and duodenal ulcer were investigated in a population based cohort study of 16,739 patients who were prescribed the H2-antagonist cimetidine between 1977 and 1981. An excess risk for gastric cancer was observed, with a relative risk of about 10 in the first year after beginning use of the drug, which decreased thereafter. A similar pattern was seen for cancers of the colon, pancreas and gall bladder, and for non-Hodgkin's lymphoma. These increased risks probably represent cases in which a malignancy was misdiagnosed as a gastric ulcer. The excess risk for gastric cancer was unaffected by the method of diagnosis, the risk in those who had undergone an endoscopy being similar to those who had been diagnosed by an x-ray examination. A relative risk of 1.5-2.0 was observed for cancer of the respiratory organs, with no effect of latency, indicating that there are common risk factors for peptic ulcer and for lung cancer. Although the observed increases in cancer risk in persons receiving cimetidine is probably caused by factors other than a carcinogenic action of the drug itself, this possibility cannot be ruled out because of the short period of follow up.

Cimetidine↗
PubMed1988

Effect of bepridil on metabolic control and insulin secretion in diabetics.

In a double-blind cross-over study bepridil 900 mg followed by 300 mg daily for 11 days was given to 37 insulin (Type I) or non-insulin (Type II)-dependent diabetic patients. It did not modify the metabolic control of the patients as levels of glucose in blood and urine, doses of insulin and oral hypoglycaemic drugs, energy intake, and the number of hypoglycaemic attacks during therapy were unchanged. The serum concentration of C-peptide was not modified in either type of diabetic patient, and serum insulin in the Type I but not in the Type II patients was slightly higher during active drug treatment. No adverse organotoxic or arrhythmogenic effects or changes in possible atherogenic lipid fractions in serum could be demonstrated during bepridil therapy.

Adult↗
PubMedDate not supplied

Mitral and aortic valvular flow: quantification with MR phase mapping.

When magnetic resonance phase mapping is used to quantitate valvular blood flow, the presence of higher-order-motion terms may cause a loss of phase information. To overcome this problem, a sequence with reduced encoding for higher-order motion was used, achieved by decreasing the duration of the flow-encoding gradient to 2.2 msec. Tested on a flow phantom simulating a severe valvular stenosis, the sequence was found to be robust for higher-order motion within the clinical velocity range. In eight healthy volunteers, mitral and aortic volume flow rates and peak velocities were quantified by means of phase mapping and compared with results of the indicator-dilution technique and Doppler echocardiography, respectively. Statistically significant correlations were found between phase mapping and the other two techniques. Similar studies in patients with valvular disease indicate that phase mapping is also valid for pathologic conditions. Phase mapping may be used as a noninvasive clinical tool for flow quantification in heart valve disease.

Aortic Valve↗