Only one type of benzo(a) pyrene-DNA adduct is detected in transformable mouse cells.
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7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide↗
Biomedical subjects
K Lo
Publications and source records attributed to K Lo.
The importance of adequate exercise in the detection of coronary heart disease by radionuclide ventriculography.
Rest and exercise radionuclide ventriculograms were obtained on 77 symptomatic patients without prior documented coronary artery disease (CAD). Coronary artery disease was present by angiograms in 48. Radionuclide ventriculography (RNV) was abnormal in 41 patients (overall sensitivity 85%). In 29 patients with normal coronary arteries, RNV was normal in 24 (specificity 83%). To determine if the exercise level affects sensitivity, the studies were graded for adequacy of exercise. It was considered adequate if patients developed (a) chest pain, or (b) ST segment depression of at least 1 mm, or (c) if they achieved a pressure rate produce greater than 250. Among the 48 patients with coronary artery disease, 35 achieved adequate exercise. Thirty-three had an abnormal RNV (sensitivity 94%). In 13 patients who failed to achieve adequate exercise, RNV was abnormal in eight (sensitivity of only 62%). Some patients with coronary artery disease may have a normal ventricular response at inadequate levels of stress.
Angiography↗
Exercise radionuclide ventriculography: practical considerations and sensitivity of coronary artery disease detection.
Eighty-nine patients were evaluated for coronary artery disease (CAD) with exercise radionuclide ventriculography (ERV) and contrast coronary angiography. In 70 patients with documented lesions the ERV was abnormal in 65 for a sensitivity of 93%. In patients with normal coronary arteries, the ERV was abnormal in none for a specificity of 100%. Sensitivity of ERV for detecting CAD was affected by the level of exercise achieved. In patients with documented CAD who achieved adequate exercise (i.e., pressure rate product (PRP) greater than 250 or the development of angina or ST segment depression during exercise), the sensitivity was 98% (56 of 57 patients). In those with documented CAD who failed to achieve adequate exercise, the sensitivity was 69% (9 of 13 patients).
Angiography↗
Exercise radionuclide ejection fraction: correlation with exercise contrast ventriculography.
Thirty-one patients with known or suspected coronary artery disease or aortic valvular disease were studied at rest and during supine bicycle exercise with radionuclide and contrast left ventriculography. The radionuclide ejection fractions calculated independently by three observers correlated well at rest (r = 0.96) and with exercise (r = 0.94). The calculated values also correlated well with those obtained for contrast ventriculography using the area-length method Dodge (r = 0.89 at rest and r = 0.90 with exercise). The results suggest that further clinical applications of exercise radionuclide ventriculography are justified.
Cardiac Output↗
Carbonic anhydrase activity in human cervical mucus and its response to various contraceptives regimes.
Carbonic anhydrase activity is present in human cervical mucus throughout the normal menstrual cycle. Lowest activity occurs in the ovulatory phase. A similar pattern of activity is seen in the presence of either an 'inert' or copper-releasing intrauterine contraceptive device (IUCD). The overall levels of activity are not significantly altered by the presence of either type of IUCD. A cyclic pattern of activity is retained even though endogenous ovarian function is suppressed by combined oestrogen-progestogen oral contraceptives.
Carbonic Anhydrases↗