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Biomedical subjects

K Lothe

Publications and source records attributed to K Lothe.

8 recordsLinked to original sources
PubMed1989

Formation of double contour as a repair reaction in the human femoral head.

Thirty-two femoral heads from autopsy material with arthrotic changes and 12 surgical specimens of femoral heads with different diseases have been examined with respect to their ability to form a 'double contour'. An additional bony plate within the cartilage, giving rise to the double contour, occurred only in the non-pressure zone of the articular cartilage. There were no major differences between autopsy and surgical material and these changes could also not be found in normal femoral heads. The origin of a double contour could be traced to tissue elements penetrating the subchondral bone from the bone marrow, and was the result of a gradual transformation with chondroid tissue as the starting material. We observed a similar transformation leading to lamellar bone in association with pannus.

Adult↗
PubMed1985

Focal lacunar resorption in the articular cartilage of femoral heads.

Human articular cartilage taken from 92 femoral heads at autopsy was examined macroscopically and microscopically. Fifty-two showed no changes except for occasional slight degeneration in the non-pressure areas; these changes were visible only microscopically. In the remaining 40 heads, different degrees of osteoarthrosis were seen; half the heads also showed focal lacunar resorptive lesions in the cartilage. The origin of this focal cartilage resorption is discussed and its possible association with necrosis, pannus formation and enzymatic synovial activities. We conclude that there is no evidence of a direct relationship between focal cartilage resorption and osteoarthrosis.

Adult↗
PubMed1979

Human articular cartilage in relation to age, A morphometric study.

The cell density of the weight-bearing area of normal femoral head cartilage was investigated in 65 cases of both sexes ranging from 6 to 90 years of age. In the maturing cartilage (until about the third decade), the cell density decreases, while in aging cartilage (30-90 years) it remains constant. Our results are in agreement with the main trend of earlier and similar investigations. The reason for contradictory reports is suggested to be due to differences in the selection of criteria for defining 'normal' cartilage. This problem is particularly acute with advancing age, where a great part of the available material shows degenerative changes.

Adolescent↗
PubMed1976

Human agglutinins to rabbit erythrocytes. Characterization of an antigen.

Crude preparations inhibiting the agglutination of rabbit erythrocytes by pooled human serum were obtained by extraction of erythrocyte stromata with various solvents (chloroform/methanol, trichloroacetic acid, and so forth). Highest inhibiting activity was found in a preparation containing sphingoglycolipid; 0.8 mug inhibited 2 agglutinating units of serum. The active preparations retained their activity after 5 min of incubation in a boiling water bath and after treatment with proteolytic enzymes or neuraminidase. Treatment with periodate abolished the activity. The antigenic site is therefore probably determined by the sugars of the sphingoglycolipid.

Agglutination Tests↗