[Stage-related treatment of diabetic retinopathy].
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Biomedical subjects
Publications and source records attributed to K Lucke.
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In most cases of advanced proliferative vitreoretinopathy (PVR) relief of anterior traction can be achieved by careful dissection of the vitreous base. In more complicated cases, a peripheral, usually inferior retinectomy is necessary. We have analyzed retrospectively 51 cases of advanced PVR, in which we performed a combined vitrectomy-silicone oil procedure with peripheral retinectomy. In 90% of the cases, the retinectomy was done during a reoperation. In 24 of 51 patients (47%) the crystalline lens could be preserved until removal of the silicone oil. At the end of follow-up (more than 6 months, mean 13 months), the retina was attached in 37 of 51 cases (72.5%) Reproliferation caused redetachment in 12 of the 14 failures. Reproliferation with renewed traction on the central retina frequently required revision with extension of the retinectomy, but in most eyes anterior traction could be managed successfully by this technique.
Transscleral coagulation of the ciliary body was performed by means of the continuous wave Neodymium: YAG laser in 39 eyes with various types of secondary glaucoma that was not controlled by medical therapy. Three days later, the mean intraocular pressure measured 54% of the pre-laser pressure; 3 months later it was 52%, 6 months later 47%, and 12 months later 58%. In 11 of 14 eyes (78.6%) treated in an attempt to preserve the remaining visual function, the pressure proved to be under control (less than or equal to 20 mmHg) 6 months after treatment. Major complications, such as hyphema or bleeding into the vitreous, were rare (7/39) and occurred only in the eyes with neovascular glaucoma.
We recorded visual-evoked cortical potentials before and after pars plana vitrectomy and intravitreal liquid silicone filling in 30 patients (30 eyes) with complicated retinal detachments without vascular eye disease or glaucoma. The flash- and flicker-evoked cortical potentials increased in amplitude in all cases. Of 21 eyes followed up for more than 50 days, eight had a 30-Hz flicker response before and after surgery. Of 13 eyes with preoperatively reduced flicker-frequency responses, ten (77%) were improved after surgery. The visual-evoked cortical potential parameters did not deteriorate in any of the patients. We concluded that no toxic effect of intravitreal liquid silicone on the optic nerve could be shown by electrophysiologic methods.
On the basis of a series of 500 patients the authors describe the development of silicone oil surgery, the surgical technique, and present-day indications for it, as well as the results that can be achieved with this procedure. The postoperative problems (cataract, glaucoma, and keratopathy) are analyzed and guidelines presented for reducing the complication rate.
The authors report on three patients with acute retinal necrosis who were treated with the virostatic agent Acyclovir and who underwent vitreoretinal surgery with silicone oil filling for total retinal detachment. In two eyes the retina was reattached, but useful vision was only preserved in one patient. Titers from blood and the vitreous, as well as microscopic findings in retinal biopsies, support the view that the necrosis is caused by a herpes simplex virus infection. After therapy with Acyclovir was instituted no further progression on the necrosis was observed. However, the development of retinal detachment could not be prevented. Early diagnosis and antiviral therapy are essential to improve the otherwise poor prognosis in this rare syndrome.
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The results of silicone oil surgery in a consecutive series of 500 patients are reported. Special emphasis is given to anatomical and functional long-term results, postoperative glaucoma and keratopathy, and to the results following silicone oil removal.
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A series of 500 consecutive pars plana vitrectomies was evaluated with regard to retinal complications. If the retina is attached preoperatively the risk of retinal complications is only 2.0%; however, in cases with preoperative detachment it rises to 9.2%. When membrane peeling is performed the risk rises by a further 7.3%. These statistics support the view that early vitrectomy is today a safe operation in cases with a simple initial anatomical situation. In contrast, late vitrectomy in cases where the initial anatomical situation is complex and membrane-peeling has to be performed is necessarily associated with a higher rate of complications.
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