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Biomedical subjects

K Lukács

Publications and source records attributed to K Lukács.

15 recordsLinked to original sources
PubMed1991

Decrease in the carbamylcholine-induced chemotaxis of monocytes in myasthenia gravis.

The carbamylcholine-induced chemotaxis of monocytes was decreased in patients with myasthenia gravis, whereas no change was found in the C5a-induced locomotion of these cells compared with that of the normal controls. The decrease in the chemotaxis induced by carbamylcholine correlated with the severity of clinical symptoms. The beneficial effect of thymectomy was also reflected in the improvement of chemotaxis. The method is simple, not expensive and could be used in the diagnosis of myasthenia gravis.

Carbachol↗
PubMed1989

[Essential hypertension caused by a virilizing adrenal tumor].

Authors report here an interesting case of a woman who has been treated for essential hypertension for 12 years. Beside the hypertension, an extreme virilization appeared. A large adenoma, originated from the left adrenal gland have been explored behind the clinical picture. After surgical removal of the adenoma, adrenocortical hormones decreased to the normal levels. Systemic blood pressure decreased considerably the virilisation showed gradual involution. The correct treatment of the patient was a decade late, resulting in the development of encephalopathic syndromes.

Adrenal Cortex↗
PubMed1988

Function of monocytes in patients with systemic sclerosis.

Functions of monocytes from the peripheral blood of 23 patients with systemic sclerosis were investigated in vitro. The yeast phagocytosis, opsonized yeast phagocytosis and binding of EA (erythrocyte-antibody) particles were found to be normal. A depressed chemotactic response was demonstrated against a zymosan-activated, complement-derived chemotactic factor. In 12 cases, monocytes were cultured for 168 hours. By the 5th and 7th days, the initially depressed chemotactic activity of monocytes returned to normal as compared to controls. This fact supports the speculation that the decreased chemotaxis cannot be caused by an intrinsic abnormality of monocytes/macrophages in systemic sclerosis.

Adult↗
PubMed1987

Altered monocyte functions in patients with angioimmunoblastic lymphadenopathy.

Monocyte function was investigated in ten patients with angioimmunoblastic lymphadenopathy (AILD). Although spontaneous migration, phagocytosis and opsonisation of monocytes were unimpaired, the chemotactic response and erythrocyte-antibody-rosette (EA-rosette) formation were decreased significantly. The migratory response of normal monocytes was inhibited on preincubation with serum from AILD patients. It is suggested that the immune abnormality in AILD, previously thought to involve T-B and natural killer lymphocytes, extends to the monocyte-macrophage system.

Adult↗
PubMed1985

Effect of dialysable leukocyte extract on the mononuclear leukocytes in Hodgkin's disease.

Therapy with dialysable leukocyte extract repeated 6 times, had a beneficial effect on the impaired functions of mononuclear leukocytes in Hodgkin's disease. The decreased phagocytosis and chemotaxis of monocytes increased almost to the values of healthy controls. There was no significant change in the C3b receptor activity of the patients' monocytes but their pathologically increased EA rosette formation showed some correction during dialysable leukocyte extract therapy. The number of T cells bearing histamine and IgG Fc receptors was reduced initially and increased during therapy but this effect was only temporary. The results suggest that the stimulating effect of dialysable leukocyte extract on cellular immunity was due partly to the correction of mononuclear phagocyte functions rather than an effect on lymphocyte subpopulations in Hodgkin's disease. The beneficial effect of transfer factor on mononuclear phagocyte function may affect the rate of tumour progression and reduce the number of severe infections in patients with Hodgkin's disease.

Antigen-Antibody Complex↗
PubMed1985

Inhibitory effect of monocyte reactive antibodies on monocyte chemotaxis in systemic lupus erythematosus.

Presence of different types of autoantibodies is a basic feature of systemic lupus erythematosus (SLE). Though monocytes, macrophages play an important role in cellular immunity, autoantibodies against monocytes have not been sufficiently studied. The authors used automatic fluorochromatic assay to detect monocyte reactive autoantibodies in the sera of SLE patients. Of SLE 35.5% sera showed complement-mediated monocytotoxic activity against healthy monocytes. Monocyte reactive SLE sera as well as monoclonal antibodies against human monocytes inhibited chemotaxis of control monocytes. The results suggest that monocyte reactive autoantibodies may play a role in the decreased monocyte number and defective monocyte functions observed in SLE.

Antibodies, Monoclonal↗
PubMed1979

Circulating immune complexes and monocyte Fc function in autoimmune diseases.

The phagocytosis of separated and adherent monocytes of patients with systemic lupus erythematosus is subnormal as compared to controls on the basis of latex and yeast uptake. The monocytes from the same patients react with antibody-coated sheep red blood cells in a significantly higher degree than normal monocytes. There is a correlation between the percentage of reactive monocytes and the serum immune complex content. After brief treatment of patients with levamisole the phagocytic function of monocytes is restored and at the same time the circulating immune complex content is decreased.

Antigen-Antibody Complex↗
PubMedDate not supplied

Monocyte functions in patients with mixed connective tissue disease.

The authors investigated the number and functions of peripheral blood monocytes in patients with mixed connective tissue disease. Moderate monocytopenia was detected in the active stage of the disease. There was a close correlation between the sensitized sheep red blood cell binding capacity of monocytes and the elevated levels of circulating immune complexes. The yeast phagocytosis of monocytes and the chemotactic activity were normal in patients with mixed connective tissue disease. C3b receptor mediated phagocytosis of monocytes decreased in the active and inactive stages of the disease. This study suggests that the decreased function of C3b receptors of monocytes is related to the pathogenesis of this disease.

Adolescent↗
PubMedDate not supplied

Polymorphonuclear functions in patients with mixed connective tissue disease.

Polymorphonuclear leukocytes (PMNs) from 29 patients with mixed connective tissue disease (MCTD) were studied "in vitro" for their phagocytic and chemotactic function as well as for granulocyte alkaline phosphatase (GAP) activity. Fc-receptor expression detected by EA-rosette formation was comparable to the control. Yeast-phagocytosis, C3b-receptor mediated phagocytosis and chemotaxis of PMNs, however, significantly decreased in MCTD. At the same time, photometric measure of alkaline phosphatase activity indicated a nearly two fold increase in PMNs from patients with MCTD. Although no correlation was found between PMN functions and the activity of the disease, PMN disorders may play a role in pathogenesis of these connective tissue disorders.

Adult↗
PubMedDate not supplied

Adult chronic granulomatosis disease-like neutrophil granulocyte disorder corrected by dialysable leukocyte extract.

A 47 year old female presented with a septic clinical picture including fever, abscesses, late cachexia, and unmanageable by disease. Similar characteristics to chronic granulomatosis disease (CGD) seriously decreased intracellular killing activity and chemiluminescence, granulomas in the histology, and the role of genetic factors were found, suggesting that our case is CGD-like disorder, manifested in an adult. Dialysable leukocyte extract (DLE) therapy, complemented with fresh normal plasma, resulted in a striking clinical improvement and there was an increase in the in vitro PMNL intracellular killing activity, too. Although it is generally accepted that DLE derives from monocytes and lymphocytes, it is possible that DLE is a family of DNA-oligopeptide molecules, including factors derived from PMNLs which are capable of influencing PMNL function, transferring information from normal cells. Our results also suggest that it would be worth trying DLE in patients with classic CGD.

Abscess↗