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Biomedical subjects

K Lyons

Publications and source records attributed to K Lyons.

15 recordsLinked to original sources
PubMed1991

Frequency and experience with carcinoma of the thyroid at a private, a Veterans Administration, and a university hospital.

We evaluated the treatment experiences with thyroid carcinoma at a private, a Veterans Administration, and a University hospital to determine the frequency, treatment, and outcome of patients with this uncommon malignant tumor. All 120 patients with thyroid carcinoma were identified through hospital tumor registries between 1953 and 1988, representing 0.3% of the total cancer registry cases during this period. Well-differentiated carcinoma of the thyroid represented 73%, medullary carcinoma 7%, poorly differentiated carcinoma 18%, and Hürthle cell carcinoma 2% of histologic varieties. Seventy-eight percent of patients were treated initially by surgery or by surgery plus postoperative irradiation. The remaining patients received other treatment. At 10 years after treatment, 90% of patients with well-differentiated carcinoma survived, while only 20% of patients with medullary and poorly differentiated carcinoma survived. Sixty percent of recurrences for all histologic types appeared within the first 12 months after treatment. Patients with well-differentiated carcinoma had sporadic recurrences over a 21-year-period. Recognition of these time intervals allows for better follow-up management.

Adenocarcinoma↗
PubMed1990

Radiography of the paranasal sinuses--one or three views?

A prospective study of 100 adult patients undergoing paranasal sinus radiography was performed. Two experienced radiologists independently assessed a single occipitomental view and, at a later date, the traditional three projections, i.e. occipitomental, occipitofrontal and lateral. There was 99% intra-observer agreement between the diagnosis on a single projection compared with all three films. In five cases, the frontal sinuses were difficult to assess mainly due to poor radiography, and in defined circumstances additional views may be required occasionally. We conclude that with greater attention to radiographic technique the occipitomental view alone is sufficient for diagnostic purposes.

Adolescent↗
PubMed1989

Vgr-1, a mammalian gene related to Xenopus Vg-1, is a member of the transforming growth factor beta gene superfamily.

The transforming growth factor beta (TGF-beta)-related products of the Xenopus Vg-1 and Drosophila decapentaplegic (DPP) genes have been implicated in the control of growth and differentiation during embryogenesis. We have isolated a mouse cDNA, Vgr-1, that encodes a polypeptide structurally related to Xenopus Vg-1. Sequence comparisons indicate that the Vgr-1 protein belongs to a family of DPP-like gene products within the TGF-beta superfamily. The levels of Vgr-1 RNA were determined in embryos and tissues isolated at various stages of development. A 3.5-kilobase mRNA increases throughout development and into adulthood in many tissues and in F9 teratocarcinoma cells differentiating into endoderm in response to retinoic acid and cAMP. The amino acid homologies and patterns of expression suggest that, like the DPP gene product, Vgr-1 plays a role at various stages of development.

Aging↗
PubMed1988

Bulimia in a pair of monozygotic twins.

Bulimia was diagnosed in a pair of monozygotic twins and was manifested in both sisters concurrently through their adolescent years. After a later separation only one continued to manifest the disorder with additional associated features of the bulimic syndrome. The case is presented and suggestions regarding the roles of environmental and genetic factors in the development and course of the disorder are discussed.

Adult↗
PubMed1988

Bulimia nervosa in pregnancy: a case report.

Bulimia nervosa is an eating disorder characterized by secretive binge eating and purging with induced vomiting, laxatives, and diuretics. The disorder primarily afflicts young white women between 18-35 years of age. We report the case of a 30-year-old pregnant woman with a 17-year history of bulimia that involved up to six episodes of binging and purging daily. A multidisciplinary approach enabled outpatient management throughout gestation. The pregnancy resulted in the delivery of a normal 3000-g female infant at term. The ramifications for maternal and fetal well-being and the goals of therapeutic management are discussed.

Adult↗
PubMed1987

Fatty retroperitoneal tumours--plain film and computed tomographic appearances.

Three patients with large fatty retroperitoneal tumours are presented. In all three the fatty mass was visible (but initially not recognized as such) on plain abdominal radiographs. Computed tomography (CT) confirmed the presence of fat within these tumours. Attention is drawn to the importance of the correct interpretation of the plain abdominal radiograph when such fatty tumours are present. Computed tomography then proves the presence of fat as well as site of origin of such tumours.

Aged↗