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Biomedical subjects

K M Aziz

Publications and source records attributed to K M Aziz.

At least 73 records · Page 4Linked to original sources
PubMed1982

Age misstatement for young children in rural Bangladesh.

Age data for 3,393 children, six years of age and under, in rural Bangladesh are analyzed for the level and pattern of age misstatement. Random error, age heaping at whole years, and preferences for particular ages are found in the data. Variation in age reporting is discovered to increase monotonically with age. Systematic errors in age misstatement display modest overstatement for the first four years of life and more pronounced understatement for ages 4, 5, and 6. Age misstatement is examined for its effect on one indicator often used in nutritional surveillance--weight-for-age of children. The impact of the various types of age misstatement (a) increases the difficulty of interpreting weight-for-age and (b) obscures accurate understanding of malnutrition in Bangladeshi children.

Age Factors↗
PubMed1980

Failure of a large dose of vitamin A to enhance the antibody response to tetanus toxoid in children.

Field studies to determine the effects of a large dose of water miscible vitamin A on selected parameters of children's immunological function were completed in rural Bangladesh. There was no difference between vitamin A treated or control groups in tetanus antitoxin responses after tetanus toxoid immunization or in skin test reactivity to common antigens. Subsequent studies with mice demonstrated vitamin A dose-related antitoxin responses, but the animals required amounts of vitamin that would be likely cause undesirable side effects if administered in similar doses to children.

Animals↗
PubMed1980

Isolation of drug-resistant Aeromonas hydrophila from aquatic environments.

Antibiotic-resistant strains of Aeromonas hydrophila have been isolated from the natural environment in the Chesapeake Bay and areas surrounding Dacca and the Matlab region of Bangladesh. The Bangladesh strains carried resistance to chloramphenicol, streptomycin, and tetracycline, and 57% of them had a multiple streptomycin-tetracycline resistance phenotype correlated with the presence of a large plasmid. The Chesapeake Bay strains were resistant to polymyxin B ane tetracycline, but showed neither multiple resistance nor R-factor carriage. Twenty-five percent of the environmental strains were toxigenic in a Y-1 adrenal cell assay. Toxigenicity showed no positive correlation with drug resistance or with plasmid carriage. Environmental areas of heavy human impact appear to be associated with a higher incidence of antibiotic-resistant strains of aeromonads.

Aeromonas↗
PubMed1980

Seroepidemiology of rotavirus infection in rural Bangladesh.

A prospective seroepidemiological study of rotavirus infection was performed in children in a village in rural Bangladesh. Ninety-three percent of the children had detectable antibodies during the study, and there were 66 significant rises in titer occurring in 57 of the 85 children. Antibody titer rises occurred in older children and younger children with equal frequency. Nine children (11%) had evidence of multiple infections during the 16-month period. Winter infections were most frequent, although one summer (monsoon) season was also associated with a large cluster. Subjects with high titers (greater than 1:8) of antibody less frequently developed a titer rise than did subjects with lower titers.

Antibodies, Viral↗
PubMed1979

Diarrhoeal mortality in two Bangladeshi villages with and without community-based oral rehydration therapy.

To combat dehydration from diarrhoea in Shamlapur, a village of 7021 people, multiple community-based points were set up by trained volunteers for the distribution of glucose-electrolyte oral rehydration salt (ORS) packets. The comparable adjoining village, Bordil, with a population of 3888, obtained its supply of ORS from Shamlapur. Surveilance for 2 years showed that although diarrhoeal attack-rates were equal, consumption of ORS after diarrhoea was 80% in Shamlapur and 38% in Bordil. There were 8 deaths in Shamlapur caused by diarrhoea and 23 in Bordil, showing an overall case fatality-rate of 0.5% and 2.4%, respectively, and a diarrhoeal mortality-rate per 1000 population of 0.6 and 2.9, respectively. The observation indicated that although it may not be possible to reduce diarrhoeal attack-rates, easy availability of rehydration solution and its early use after village-based training may save many lives, particularly those of children.

Administration, Oral↗
PubMed1975

An outbreak of dysentery caused by Shigella dysenteriae type 1 on a coral island in the Bay of Bengal.

An epidemic of severe dysentery occurred on St. Martin Island in the Bay of Bengal at a time when the island, with a population of 1,318, was isolated from the mainland because of the monsoon season. There were 434 cases and 28 deaths within a three-month period. Mortality (2%) was limited to the very young and the elderly. Shigella dysenteriae type 1 (Shiga bacillus) was isolated from 12 of 65 rectal swab specimens. All strains gave similar biochemical reactions and were resistant to tetracycline, chloramphenicol, streptomycin, and the sulfonamides but were sensitive to ampicillin, kanamycin, and gentamicin. No other organism was implicated in the outbreak. The disease disappeared from the island after institution of chlorination of the sources of drinking water and effective treatment of patients.

Adolescent↗
PubMed1975

Epidemiologic investigation of an outbreak of Shiga bacillus dysentery in an island population.

An epidemic of dysentery broke out in St. Martin island during May through July 1973. The epidemic was caused by Shigella dysenteriae type 1. The dysentery could not be controlled by conventional antibiotics and other antidysenteric drugs. The average attack rate was 32.9%. The age specific attack rate was highest in the age group 1-4 years (52.2%). The attack rates were higher in smaller families. The rates were not greatly different amongst people using different sources of water. The overall death rate was 2.1%. The overall infection-to-death rate was 6.4% but amongst children less than a year old, it was 41.1%. A common source outbreak was unlikely. The higher attack rate in smaller families suggested limited possibility of person to person spread. No particular water source could be implicated with higher attack rate. Flies may have played an active role in transmission.

Adolescent↗
PubMed1974

Letter: Cholera.

Explore the source record for details and available documents.

Bangladesh↗
PubMed1973

Field trials of monovalent Ogawa and Inaba cholera vaccines in rural Bangladesh--three years of observation.

A controlled cholera vaccine field trial was carried out to test the efficacy of monovalent whole-cell Inaba and Ogawa cholera vaccines and a purified Inaba antigen. This study was designed particularly to study the level of protection produced by these vaccines against homologous and heterologous serotypes and to correlate the results with mouse protection tests and human serological response to the vaccines. A cohort of 45 000 children, aged 0-14 years, was divided into a control group and three vaccine groups. Inoculations were given annually for 2 years just before the start of the cholera season, and follow-up was continued for one additional year. Essentially, all cholera cases were due to the Inaba serotype, so that protection could be studied only against that serotype. Two annual injections of the whole-cell Inaba vaccine gave the highest level of protection, averaging 84% over the 3 years of follow-up; a single injection of the purified Inaba vaccine gave less protection (51%). Two annual injections of the whole-cell Ogawa vaccine failed to protect children under the age of 5 but did produce 48% protection for children aged 5-14 against Inaba cholera. Serological surveys correlated poorly with protection; specifically, the Ogawa vaccine produced high anti-Inaba titres in young children but no protection. The cross-protection against Inaba cholera produced by Ogawa vaccine in the older children is assumed to be due to boosting of naturally acquired immunity in this population. Monovalent vaccine cannot be recommended for general public health use because of the serotype specificity of protection that this study has demonstrated.

Adolescent↗
PubMed1972

Report of the 1966-67 cholera vaccine trial in rural East Pakistan.

A controlled cholera vaccine field trial was carried out in rural East Pakistan to determine the efficacy of a cholera vaccine of average antigenic potency when used in a continuing programme with annual reimmunizations. A cohort of 40 000 children aged 0-14 years was equally divided into a control group and 3 vaccine groups. Inoculations of vaccine were given annually for 3 years just before the start of the cholera season, and follow-up continued for 2 additional years. The results indicate that there was increasing protection with reimmunization, reaching a maximum with 3 doses. One dose produced 43% protection, 2 doses 64%, 3 doses 81%, and 4 doses 76%. Protection was more sustained after reimmunization; being 50% and 39%, 1 and 2 years after the fourth injection, respectively. Serological surveys suggested a general parallel in the antibody response to vaccine and the level of protection achieved; however, the levels of vibriocidal antibody titres could not be related directly to levels of protection. The overall protection achieved with the 3-year programme of annual reimmunizations was 55% for the group receiving one inoculation annually, and 65% for the group receiving 2 inoculations in the first year followed by annual reimmunizations. When the costs and effectiveness of annual vaccine programmes are compared with those for cholera treatment centres, it becomes clear that the cholera vaccines now available are not appropriate alternatives to treatment in routine cholera control programmes.

Adolescent↗