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Biomedical subjects

K M Sajid

Publications and source records attributed to K M Sajid.

5 recordsLinked to original sources
PubMed1993

Carbon monoxide fractions in cigarette and hookah (hubble bubble) smoke.

We studied the carbon monoxide (CO) fractions in hookah and cigarette smoke, using a carbon monoxide micro smokerlyzer (model EC50, BEDFONT, U.K.). Mean carbon monoxide fractions (% by volume) of hookah smoke, using domestic charcoal were 0.38 +/- 0.07 (large hookah; unfiltered); 1.40 +/- 0.43 (small hookah; unfiltered); 0.34 +/- 0.06 (large hookah; filtered); 1.36 +/- 0.35 (small hookah; filtered) and 0.41 +/- 0.08 (cigarette smoke). The highest fractions were obtained with small size hookah and increase in size of hookah (i.e., volume of air in water base, fire bowl volume, pipe length, etc.) reduced the CO fraction significantly (P < 0.001). The fractions of cigarette lie between large and small hookah. The fractions vary slightly with different varieties of tobacco, e.g., CO fractions with Dera wala tobacco are significantly low (P < 0.05). Use of commercial charcoal gives significant rise in CO fractions (P < 0.001). Comparison of filtered and unfiltered smoke shows no significant difference in values. We conclude that the CO hazard is as high with hookah smoking as with cigarette smoking.

Carbon Monoxide↗
PubMed1991

Ramadan fasting and thyroid hormone profile.

A study comprising 41 males, 5 females of the age ranging from 28 to 56 years was conducted during Ramadan of 1989 to compare T3, T4 and TSH levels in fasting with the levels of non-fasting conditions. Each individual gave 6 blood samples: One sample was taken 20 days before the onset of Ramadan, 3 samples at different fasting days and last two samples were drawn 23 days and five months after the end of Ramadan, respectively. The results showed a significant gradual rise in TSH throughout the fasting month, although the mean levels remained within normal limits. Pre- Ramadan levels were re-attained well after the end of Ramadan. There was no significant change in T3 and T4 levels.

Adult↗
PubMed1991

Local preparation, standardization and quality control of technetium labelled macroaggregated albumin for lung perfusion studies.

Lung perfusion study is an important investigation in various pulmonary diseases. The radiopharmaceutical commonly used now-a- days is imported macroaggregated human albumin (in kit form), which is labelled with technetium (Tc99m-MAA). Due to its high cost the technique could not be fully exploited. We have tried to locally prepare freeze dried MAA particles. Various parameters like concentration of protein, pH value, temperature, quality and quantity of reducing agents were studied to find out the optimum conditions for radiolabelling and the desired particle size. More than 98% of the added radioactivity was found tagged to the MAA particles in the final preparation (confirmed by paper chromatography). Labelled agent was found to be radiochemically stable for up to 6 hours. Initial animal and later human studies showed an ideal spectrum of particle size.

Chemistry, Pharmaceutical↗
PubMed1991

Qualitative evaluation of in-house immunoassays of T3, T4 and TSH based on bulk reagents.

Increase in the cost of RIA kit assays has led to our attempts to seek cheaper alternates. Assays based on bulk reagents (supplied free of cost by INMOL in collaboration with IAEA) were started in 1988. Statistical and Quality control data on 50,51 and 52 assay batches of T3, T4 and TSH respectively has been collected from the beginning. Cumulative assay parameters show that T3 and T4 assays are almost equally precise. TSH assay is most imprecise in the group especially at low concentration levels. The working ranges of T3 and T4 assays defined at 10% error limit are quite wide and cover low, medium and high levels of hormones. In TSH the assay working range does not cover levels below 10mu IU/ml. The variability of curve parameters is similar in this group of assays. Quality control results are most reproducible in T4 assays with a between batch variability of 11.9%. T3 and TSH assay results are equally reproducible (20.50% variability). Overall within assay drift is low in all assays. IQC charts of these assays show occasional significant positive or negative shift of results from mean which might be related to methodological variations of quality among various distributions of reagents. The reproducibility and precision of results could be further improved by harmonizing the future distributions of reagents.

Data Interpretation, Statistical↗