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Biomedical subjects

K M Singh

Publications and source records attributed to K M Singh.

At least 19 recordsLinked to original sources

Novel cytogenetic finding: an unusual X;X-translocation in Mehsana buffalo (Bubalus bubalis).

Cytogenetic investigations of a phenotypically normal Mehsana river buffalo calf (Bubalusbubalis) revealed an XXY chromosome complement due to X;X-translocation in all screened metaphase plates. The chromosomal anomaly was identified by GTG-banding while CBG- and RBG-banding revealed two heterochromatin blocks and that one of the two X chromosomes was late replicating, respectively. The normal cytogenetic profiles of sire, dam and relatives of the calf suggest that the anomaly could have arisen spontaneously during oogenesis. This is the first report on a male river buffalo calf having an XXY chromosome complement with translocation between the two X chromosomes.

Animals↗

Confirmation of the correct placement of lower end of DJ stent during open surgery: point of technique.

A simple technique to confirm the correct placement of the double J (DJ) stent at the time of antegrade insertion during open surgery is described. At the time of antegrade DJ stent placement about 30-50 ml of sterile methylene blue is instilled into the bladder. Appearance of methylene blue from the upper end and side holes of the DJ stent confirms the correct placement of the lower end of the stent.

Humans↗

Vesical calculi with unrepaired vesicovaginal fistula: a clinical appraisal of an uncommon association.

PURPOSE: Primary vesical calculi are uncommon in patients with vesicovaginal fistula (VVF). We retrospectively analyzed 19 such cases and present our experience with the management of this condition. MATERIALS AND METHODS: Between January 1989 and December 2002, 19 patients were treated for this association. All patients provided a history and underwent physical examination, metabolic evaluation for stone disease, urine culture test and cystovaginoscopic examination. They were treated with a staged procedure with the fistula repaired 2 to 3 months after stone removal. RESULTS: VVF was a result of obstructed labor in all cases. The patients presented a mean of 28.8 months after fistula formation. No metabolic abnormality was detected in any patient. Urine culture was positive for Proteus mirabilis in 6 and Escherichia coli in 5, and it yielded mixed growth in 8. All women had some residual urine in the bladder (mean 11 ml). The fistula was located supratrigonally in 13 cases, while it was high trigonal in the remainder. A total of 17 patients were treated endoscopically by cystolitholapexy or fragmentation of the stone by transurethral cystolithotripsy using a Lithoclast (Microvasive Urology, Natick, Massachusetts). Two patients required open suprapubic cystolithotomy. All patients underwent fistula repair 3 months after stone removal with successful results in 16. CONCLUSIONS: Primary vesical calculi in patients with VVF are associated with urinary contamination, a high or supratrigonal fistula location, residual urine in the bladder and a long history of disease. Staged management of the problem showed good results.

Bacteriuria↗

Wilms' tumour : a clinicopathologic study with special reference to its morphologic variants.

Twenty five cases of Wilms' tumour were studied with special reference to their morphological variations. Wilms' tumour constituted 7.6% of all the malignant tumours of childhood and 50% of renal malignancies. Male/female ratio was 4:1; the mean age being 3.5 years. Left side was commonly involved (60.9%) center dot bilateral involvement in one case (4.3%). Morphologic study revealed triphasic pattern in 60% cases, biphasic (epithelial + stromal) in 12% and monophasic pattern in 28%. Other features observed were myxomatous degeneration, rhabdomyoblasts, calcification and squamous epithelial pearls seen in 20%, 12%, 8% and 4% respectively.

Adolescent↗

Tumours of the male urogenital tract: a clinicopathologic study.

The present communication deals with the study of 388 tumours of the male urogenital tract diagnosed histopathologically during the period of 1984 to 1990. Of these 12 (3.09%) were benign and the rest 376 (96.91%) malignant. The incidence of malignant growths of male urogenital tract was 8.71% of all the malignancies or 14.19% of all cancers in males. Renal tumours constituted 10.64% of all the malignant tumours of male urogenital tract or 1.51% of all the male cancers. Morphological variants were renal cell carcinoma (37.5%), Wilms' tumour (47.5%), transitional cell carcinoma (7.5%), papillary cystic adenocarcinoma (3.5%), leiomyosarcoma (2.5%), metastatic from thyroid (2.5%). The mean age of the cases for renal cell carcinoma was 50.3 years and for Wilms' tumour 3.5 years. Urinary bladder cancer comprised 29.52% of all the malignancies of male urogenital tract or 4.19% of all malignant growths in males. The average age of the patients was 53.9 years. Transitional cell carcinoma was the commonest type of tumour (91.9%). Primary malignant tumours of the testis constituted 0.95% of all the malignancies, 1.55% of all male cancers, 10.9% of all malignancies of male urogenital tract or 18.3% of all the malignant growths of male genital tract. The mean age of the patients was 40.6 years. Seminoma was the commonest -46.34% of all the testicular tumours. The incidence of prostatic cancer was 1.81% of all cancers, 2.95% of all malignancies in males or 20.74% of all malignancies of male urogenital tract or 34.82% of malignancies of male genital tract.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Muscle and serum adenosine triphosphatase in patients suffering from tetanus.

Serial estimation of muscle and serum adenosine triphosphatase (ATPase) activity was performed in 16 healthy control patients and 32 cases with tetanus. There was no significant difference due to age and sex in muscle and serum ATPase activity between the normal and tetanus cases. Tetanus patients showed a marked increase in muscle and serum ATPase activity as compared to normal. The ATPase activity increased with the severity of convulsion and disease. There was increased mortality in tetanus patients having higher values of muscle and serum ATPase.

Adenosine Triphosphatases↗

Goldenhar syndrome.

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Abnormalities, Multiple↗