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Biomedical subjects

K Mäkelä

Publications and source records attributed to K Mäkelä.

At least 19 recordsLinked to original sources
PubMed2005

Effect of total colectomy and PYY infusion on food intake and body weight in rats.

PYY (3-36) is postulated to act as a satiety factor in the gut-hypothalamic pathway to inhibit food intake and body weight gain in humans and rodent models. We determined the effect of 14-day continuous intravenous infusion of PYY (3-36) (175 microg/kg/day) on food intake and body weight gain in colectomized male Wistar rats. Colectomy caused an increase in plasma PYY levels at 7 days which was reduced at 14 days but still significantly elevated compared to basal preoperative values. Animals treated with continuous PYY (3-36) infusion had significantly elevated PYY levels compared to the control group throughout the whole experiment, but showed a similar pattern of food intake and body weight gain. In conclusion, although continuous intravenous infusion is the most physiologically relevant method to mimic high postprandial PYY levels, we did not observe any significant effect on food intake and body weight gain in non-food deprived colectomized animals. This suggests that PYY has, if at all, only a minor role in food intake in rats.

Animals↗
PubMed2005

Electronic patient record systems and the general practitioner: an evaluation study.

We studied how well electronic patient record (EPR) systems meet the needs of general practitioners (GPs) and other health-care professionals for specific information. GPs in eight health centres in the South-Ostrobothnia region of Finland were invited to participate. They used three types of EPR system. They were asked to access EPRs to obtain 20 types of information for patients receiving anticoagulant treatment. In total 2,389 patient cases were studied. All of the information requested was available for 73% of the cases (range 55-93%). There was a significant difference between the type of EPR system and the percentage of patients for whom information was available through the EPR. However, further analysis showed that differences in performance between EPR systems probably reflected differences in the way EPRs were used by different organizations. Great care should be taken in attempts to rank EPR systems based on their performance.

Attitude of Health Personnel↗
PubMed2001

Characterization of wet massing behavior of silicified microcrystalline cellulose and alpha-lactose monohydrate using near-infrared spectroscopy.

The purpose of this study was to investigate the energetic state of water in silicified microcrystalline cellulose (SMCC) and alpha-lactose monohydrate wet masses using near-infrared (NIR) spectroscopy. The applicability of NIR spectroscopy to studying pharmaceutical wet masses at a wide moisture range was evaluated in comparison with mixer torque rheometry (MTR). With increasing moisture content changes in the physical properties of the samples resulted in an apparent increase in log (1/R) throughout the whole spectrum. The upward displacement of baseline and the relative height of water bands were greatest with materials that had a poor liquid-retention capacity. In the case of SMCC and 1:1 mixture of SMCC and alpha-lactose monohydrate, the height of the baseline-corrected water bands increased linearly at low moisture contents, thereafter achieving a plateau stage. According to the MTR results, the plateau stage of the band heights indicated a capillary state of liquid saturation. The second derivative spectrum was capable of distinguishing monohydrate, absorbed, and adsorbed water, which overlapped in the absorbance spectrum. When water was absorbed to the internal structure of the material (SMCC), the water bands were first seen at higher wavelengths, then followed by a shift to lower wavelengths. When water was only adsorbed onto the surface of the particles (glass ballotini), the water bands were seen directly in the region of bulk water.

Crystallization↗
PubMed2000

Relationships of drinking behaviour, gender and age with reported negative and positive experiences related to drinking.

AIMS: To assess associations between drinking behaviour, gender and age with reported experiences related to drinking. DESIGN: Cross-sectional survey. SETTING AND PARTICIPANTS: Interviews were performed in 1992 with a representative sample of the Finnish population between 15 and 69 years of age (N = 3446). MEASUREMENTS: Annual intake of alcohol, frequency of drunkenness, and 14 negative and eight positive reported experiences related to drinking. FINDINGS: Logistic regression models showed that overall intake and frequency of drunkenness were independently associated with almost all reported positive and negative consequences of drinking. Women more commonly reported that drinking had helped them to sort out interpersonal problems at home or in the work-place, to feel more optimistic about life, and to express their feelings. Men more commonly reported that drinking had helped them to be funnier and wittier and to get closer to the opposite sex. Drunken driving was markedly male behaviour, but women more commonly reported other types of reckless behaviour and adverse consequences of drinking. However, men more commonly said they were criticized by family for their drinking. With the exception of health problems, both positive and negative consequences of alcohol were more common among younger drinkers. CONCLUSIONS: Once overall intake and frequency of drunkenness were controlled for, significant differences between men's and women's perceptions of the costs and benefits of alcohol consumption emerged. Men tended to perceive more hedonic benefits while women perceived more functional benefits. Women reported behaving more recklessly in drinking situations. In light of the results, women were not under selective social control.

Adolescent↗
PubMed2000

Typologies of the cultural position of drinking.

OBJECTIVE: Typologies of the cultural position of drinking from the social science literature are reviewed. METHOD: The article reviews significant studies and literature on the topic. RESULTS: Starting in the 1940s, two research traditions considered variations in the cultural position of drinking as explanations of rates of drinking problems. A "holocultural" tradition coded and analyzed ethnographic data on tribal and village societies, starting in the 1940s, with each study identifying a different social dimension as crucial. A "sociocultural" tradition distinguished abstinent cultures from prescriptive cultures, in which drinking was integrated with daily life, and expected, but drunkenness was prohibited. These types were implicitly contrasted with American drinking, which was variously characterized. Other dimensional and typological approaches in the literature are considered, including a little-known Jellinek typology. Problems with the widely used distinction between "wetter" and "drier" (or "temperance") cultures are discussed. CONCLUSIONS: Four ideal types of the cultural position of drinking can be readily distinguished: abstinent societies, constrained ritual drinking, banalized drinking and fiesta drunkenness. A large residual category remains, however, and a dimensional approach to typology building may be more fruitful. Two basic dimensions are proposed--regularity of drinking and extent of drunkenness--and further dimensions are described that may be added to fit the requirements of the particular study.

Alcohol Drinking↗
PubMed1999

Relationships between characteristics of drinking occasions and negative and positive experiences related to drinking.

The relationships between characteristics of drinking occasions and experiences related to drinking were studied. Interviews were conducted in 1992 with a representative sample of the Finnish population between 15 and 69 years of age. The analyses were based on 10,039 drinking occasions of 1,483 male and 1,373 female drinkers. Intake of alcohol and the frequency of drunkenness were the most important predictors of both negative and positive experiences related to drinking. Characteristics of the drinking situations contributed significantly to the explanatory models, but their predictive power was small. Public and large-group drinking situations tended to increase and private and intimate situations tended to decrease the number of both negative and positive experiences related to single drinking occasions. The same situations that lead to increased positive experiences with drinking also increase the risk for negative experiences.

Adolescent↗
PubMed1997

Drinking, the majority fallacy, cognitive dissonance and social pressure.

In drinking and drug surveys, peers are perceived as drinking more and using more drugs than the respondent. Particularly in youth studies, this majority fallacy is often interpreted as an indication of peer pressure toward drinking and drug use. However, exaggerating the alcohol and drug behaviours of significant others may be a way of reducing cognitive dissonance. The behaviour of most people deviates from their ideal norms. The ensuing dissonance can be alleviated by introducing the behaviour of others as a third element in the cognitive field. Data from three Scandinavian surveys support the following two predictions based on the theory of cognitive dissonance: (1) The tendency to report that other people drink more than oneself is more marked in restrictive than in permissive communities. (2) On each level of alcohol intake, the tendency to report that other people drink more than oneself is stronger among respondents having negative alcohol attitudes than among respondents with positive attitudes to alcohol. The need to alleviate the cognitive dissonance caused by a discrepancy between actual behaviour and normative standards is thus one of the mechanisms generating the majority fallacy: "I may not be perfect, but other people are still worse". Feeling better than others does not necessarily amount to a pressure to turn bad.

Adolescent↗
PubMed1996

Inter-hospital comparison of Ganzfeld ERG photostimulators.

The periodic calibration and control of electroretinographic (ERG) stimulators is often neglected due to the difficulties in accurate measurements of the stimuli. Comparison of measurements carried out in different laboratories has been very difficult, as the accurate parameters of the stimuli used usually are not known. In some cases it is assumed that if the stimulator type is known, comparisons can be carried out. We have tested the Ganzfeld flash stimulators used in the departments of clinical neurophysiology of 3 major hospitals in Finland, namely Kuopio University Hospital, Turku Central University Hospital, and Tampere University Hospital, Measurements, performed with a new type of photometer, show that the intensities varied by 42% between the highest and lowest intensity stimulators at nominally identical settings. The measurements underline the findings that identical stimulators will not necessarily produce identical stimuli. These observations also indicate that the stability of the stimuli can be improved by the proper choice of stimulator output settings.

Electroretinography↗
PubMed1996

Suppression of F-VEP during isoflurane-induced EEG suppression.

We recorded visual evoked potentials (VEPs) to flash stimuli in moderately deep anaesthesia when EEG showed burst suppression pattern. Flash VEPs could consistently be recorded in all 8 test subjects during bursts but not during suppressions. We conclude that during isoflurane-induced EEG suppression VEPs to flash stimuli are also suppressed. This effect should be taken into account in evoked potential testing during anaesthesia.

Adult↗
PubMed1995

Significance of electrical brain activity in brain-stem death.

A 46-year-old man was diagnosed clinically brain dead after sustaining head trauma. The patient was in deep coma, brain nerves were unresponsive and spontaneous breathing was absent. However, EEG showed well preserved activity, but no reactivity to external stimuli. EEG activity disappeared within 40 h. BAEP were highly abnormal, flash-VEP as recorded 3 h after the diagnosis of brain stem death was of high amplitude but of simplified form. The neurophysiological findings revealed that the main reason for deep coma was brain stem damage while cortical activity was still present. This condition raises ethical questions when brain death is diagnosed clinically prior to removal of organs for transplantation.

Accidental Falls↗
PubMed1995

Visually evoked bursts during isoflurane anaesthesia.

We studied EEG reactivity to visual stimuli during deep isoflurane (1.5-2.05 vol% end-tidal concentration) anaesthesia. Twelve patients were anaesthetized with isoflurane until burst suppression occurred in the EEG. Red LED goggles were used to give visual stimulation of 60 flashes, 4-ms duration each, at a frequency of 20 Hz. The stimuli, 3-strains of flashes, were given at random intervals. Both onset and offset of stimulation evoked bursts. The latency of visually evoked bursts was comparable with long latency evoked potentials, which are known to be related to cognitive processing. Our data showed that the central nervous system reacts strongly to photic stimulation during deep anaesthesia.

Anesthesia, General↗
PubMed1995

Propofol and isoflurane induced EEG burst suppression patterns in rabbits.

The aim of this study was to compare propofol produced EEG burst suppression with isoflurane produced burst suppression in rabbits and to see whether rabbits can serve as models in studying the effects of different anaesthetics on human EEG. We recorded EEG of eight rabbits anaesthetised with isoflurane and propofol. The isoflurane bursts had higher amplitude than propofol bursts (P < 0.005). Isoflurane bursts appeared on distinct DC-shifts while propofol bursts were on slow waves. The EEG patterns were, however, different from those seen in humans. Rabbits did not have the rhythms seen in humans. We conclude that rabbits can be used to study the EEG effects of anaesthetics, such as the timing properties and reactivity of burst suppression pattern. However, this model seems less promising in the study of rhythmic activity seen in human EEG during burst suppression.

Anesthesia↗
PubMed1995

Effect of platelet count on serum and plasma potassium: evaluation using database information from two hospitals.

The availability of retrospective data from potassium (K+) analyses from two hospitals, one using serum and the other plasma for electrolyte measurements, offered us the possibility to investigate the effect of blood platelet count on serum and plasma K+ concentrations. A weak correlation between plasma K+ and platelet count was observed. The in vitro increase of serum K+ in proportion to the platelet count has clinical significance in conditions, where it may impede the detection of an underlying true K+ disorder. Nomograms and correction factors, based on the correlation between platelet count and serum K+, have been suggested also in some recent reports. In the present study unselected routine patient data was used as source data. The effect of platelet count on the concentration of K+ in serum was lower than reported in previous studies, as indicated by the regression analysis. An increase of 1000 x 10(9)/l in the blood platelet count would cause an increase of about 0.7 mmol/l in the serum K+ concentration (p < 0.0001, r = 0.155). The weak correlation between platelet count and serum K+ does not support the application of platelet-count-based correction of serum K+ level in thrombocytosis. The laboratory should notify the clinician of the significance of the in vitro increase of K+ caused by increased platelet count. K+ should be measured from plasma in such cases.

Artifacts↗
PubMed1994

Rates of attrition among the membership of Alcoholics Anonymous in Finland.

Anniversary announcements published in the national AA newsletter are used to analyze membership turnover in Finnish AA. Of the total membership with at least 1 year of sobriety, close to 90% continue as sober members for another year. Of those having 1 year of sobriety, about two-thirds survive to the next year. The survival rate of members with between 2 and 5 years of sobriety is about 85%. Among members with more than 5 years of sobriety, the survival rate is above 90%. There are no gender differences in survival rates. The sober membership of AA represents between one-third and one-fifth of general population survey estimates of the number of abstaining former frequent drinkers with concerns about losing control over their drinking behavior.

Adolescent↗
PubMed1994

Female and male life stories published in the Finnish Alcoholics Anonymous journal.

To study differences in how women and men describe their drinking problems, key expressions were recorded in 50 female and 50 male stories published in the Finnish A.A. (Alcoholics Anonymous) journal. Men show more interest in the past and try to understand their lives in causal terms. Women focus on the present and on experiences in A.A. Men more frequently mention narcotics and alcohol substitutes; medical drugs are more common in female stories. Men's stories more frequently contain social deviance. Women pay more attention to social relationships. The phrase Higher Power is used with equal frequency, but women more commonly use the word God. Women express more positive emotions. Registers of negative emotions differ. The drinking man is threatened by feelings of inferiority; the drinking woman by shame and guilt.

Adult↗
PubMed1991

Social and cultural preconditions of Alcoholics Anonymous (AA) and factors associated with the strength of AA.

In 1986, AA activities (a minimum of five groups) typically occurred in non-socialist, non-Islamic countries with a GNP per capita above US$ 1000. From 1965 to 1986, the share of English speaking and Scandinavian countries of all AA groups diminished, and the share of Central and Southern European, and particularly of Latin America, increased. Correlation analysis of countries fulfilling the typical preconditions of AA indicates changes in the relationships of AA to social background factors. In 1965, AA was strongest in the wealthiest countries, but no such correlation was observed in 1986. The rate of growth of AA has been higher in Roman Catholic countries. Wine consumption is negatively and beer consumption positively correlated to the strength of AA. Cross-sectional strength of AA is not related to spirits consumption, but its rate of growth has been higher in countries where spirits are consumed. The first wave of diffusion brought AA to the Anglo-Saxon and Protestant world. The second wave covered American and European Catholic countries, and bridgeheads have been established in newly industrialized nations. Still, AA remains a phenomenon of developed and wealthy societies.

Alcohol Drinking↗