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Biomedical subjects

K Mücke

Publications and source records attributed to K Mücke.

6 recordsLinked to original sources
PubMed2000

Psychooncological provision in a general hospital: the Herford model.

Since October 1995 a Department of Psychooncology exists at the Herford Community Hospital. It was founded by a private foundation with the aim of supporting patients who suffer from cancer. The psychooncological section is an independent unit. This state of independence proved to be very useful and functional. The Herford Model is based on four compartments: psychosocial support for the patients; support for the patients' relations; the education of doctors and nurses; the evaluation of the activities of the team members, one music therapist and three psychologists. During the past 2.5 years 846 patients have had contact with the Department of Psychooncology. The mean age was about 62 years within a range from 15 to 92 years. Of the patients, 48% were men and 52% were women. The maximum number of meetings was 49: 29% of the patients had between four and eight therapeutical meetings, 12% had more than nine sessions. It is the aim of this report to show how the section is organized. The daily work and the rate of provision is shown and an outlook of the team's work in the future is given.

Adolescent↗
PubMed1997

Anesthesia and pain management in pediatric burn patients.

Patients with severe burn injury are a challenge for the pediatric anesthesiologist. Today with adequate care many children survive their trauma and have a good chance for complete functional and psychological rehabilitation. The anesthesiologist has to provide excellent care even for patients in suboptimal or unstable condition to enable wound debridement and grafting, because only rapid skin closure will stabilize the patient. Adequate pain treatment during all phases of burn treatment is mandatory.

Analgesics↗
PubMed1987

Extragenic and intragenic suppression of a transport mutation in the hemagglutinin gene of an influenza A virus as revealed by backcross and sequence determination.

Cooperation of viral proteins, or functional domains within a protein, can be studied by analyzing temperature-sensitive (ts) mutants and revertants carrying suppressor mutations. Accordingly, we have sequenced the hemagglutinin (HA) genes of a ts mutant of fowl plague virus (FPV), with a transport defect in the HA, and of five independent ts+ revertants (R1, R3, R4, R5, and R9). The amino acid replacement in position 480 from Thr to Ile, leading to the loss of a complex carbohydrate side chain, is responsible for the ts phenotype. R3, R4, and R5 are true revertants in that they have Thr in position 480, while R1 and R9 have kept Ile. The sequence of the HA of R1 is exactly the same as that of the ts mutant, while the R9 HA has two additional amino acid replacements in positions 91 (Lys-Thr) and 104 (Gly-Val). By doing a backcross with wild-type virus, it was shown that R1 carries an extragenic suppressor mutation, while R9 is intragenically suppressed. We conclude that the HA is transported from the site of its synthesis in the rough endoplasmic reticulum (RER) to the plasma membrane along with another viral gene product, which by mutation can complement the ts defect. An alternative interpretation is that the ts mutation results from a change in HA which allows an interacting protein to bind HA too soon, holding it back in the RER. The suppressor mutation may remove this premature interaction.

Animals↗
PubMedDate not supplied

[Psycho-oncology in the Herford district clinic--the Herford model].

Following successful implementation of psychooncological support in a community hospital the focus has now been shifted to build up support for outpatients. This concentrates on cancer patients and their relatives during and following ambulatory cancer therapy. It is important to integrate these new structures into the preexisting support structures (self-help groups and counselling centres). Experiences of recent years have shown that information and psychosocial support should also be given to families and friends of cancer patients as well as to the involved clinical staff. Outpatient groups have been und will be offered in the psychooncological aftercare. Relaxation, imagination and creative therapy help to cope with the disease and enable a health-promoting life style.

Adaptation, Psychological↗