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Biomedical subjects

K Mall

Publications and source records attributed to K Mall.

9 recordsLinked to original sources
PubMed1990

Therapeutic application of subcutaneous low-molecular-weight heparin in acute venous thrombosis.

Fifty patients presenting with acute deep-vein thrombosis were randomized in a prospective, controlled study to determine the safety and efficacy of a treatment with low-molecular-weight (LMW) heparin compared with unfractionated heparin. LMW heparin (n = 24) was administered twice daily subcutaneously at a dose of 2 X 150 anti-Xa units/kg body weight, and unfractionated heparin (n = 26) was given intravenously by continuous infusion at a dose of 450 anti-Xa units/kg body weight daily for 10 days. Doses were adjusted to maintain peak anti-Xa levels between 0.5 and 1.0 anti-Xa units per milliliter. One patient in the unfractionated heparin group and 2 patients in the LMW heparin group suffered from bleeding complications. Two patients on LMW heparin and on unfractionated heparin had high evidence of pulmonary embolism based on defects on ventilation-perfusion scintigraphy. Control phlebography and duplex sonography demonstrated a significant improvement during both treatment regimens. Reperfusion of the deep-vein system was 70% with LMW heparin and 75% with unfractionated heparin. The anti-Xa levels were significantly higher in the LMW heparin group, and activated partial thromboplastin and thrombin clotting times were significantly higher in the group receiving unfractionated heparin. Thrombin-antithrombin III complexes and D-dimer concentration decreased during the treatment, but did not differ between the two regimens. At the end of the treatment period with LMW heparin, protein C and antithrombin III were significantly higher.

Acute Disease↗
PubMed1978

[X-ray examination of the abdomen in hypnotic-sedative drug poisoning--casuistical contribution (author's transl)].

By means of an impressive example the significance of abdominal X-ray examination in cases of intoxication with hypnotic-sedative drugs is pointed out. Apart from the qualitative diagnosis (drug containing bromide) the radiological proof of shadow-giving substances also permits a quantitative clinical assessment and has prognostical as well as therapeutical consequences.

Adult↗
PubMed1978

[Lethal gastric hemorrhage caused by Hodgkin's disease (author's transl)].

A case report of a 29 years old female patient is given, who died from gastric hemorrhage in the course of generalized Hodgkin's disease. Gastroscopy was performed as an emergency procedure and the following was found: diffuse infiltration of the ventricular wall, diffuse widespread mucosal bleeding, and a big, penetrating ulcer above the angulus with an elevated circumference. The prevalence of gastric involvement during Hodgkin's disease is discussed.

Adult↗
PubMed1976

[Microangiopathic hemolytic anemia and consumption coagulopathy with metastasizing gastric carcinoma (author's transl)].

Microangiopathic hemolytic anemias (MHA) are frequently at the root of metastasizing gastric carcinoma. If the characteristic fragmented erythrocytes ("schistocytes") are found to be increased in the blood smear, this can be taken as a pointer to gastric neoplasm. Consumption coagulopathy frequently intensifies the clinical symptoms. A report of a 51-year-old woman with gastric carcinoma, MHA and consumption coagulopathy is given in whom the determination of numerous schistocytes in the peripheral blood was of decisive significance for the diagnosis.

Adenocarcinoma↗
PubMed1975

[Blood pressure in the beginning alcohol withdrawal state (author's transl)].

Blood pressure elevation was found to be a frequent cardiovascular symptom of the prodromal phase of alcohol withdrawal state: 21 of 25 patients (mean age 38 years) had hypertension (mean value 171/107 mm Hg) during the first two days of hospitalization, which returned to normal with the disappearance of the other withdrawal symptoms. Augmented activity of the sympathetic nervous systems is thought to be the most probable cause of blood pressure elevation in alcohol withdrawal state.

Adult↗