Emphysema associated with pulmonary hypoplasia in congenital diaphragmatic hernia.
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Biomedical subjects
Publications and source records attributed to K Mancer.
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A technique is described for studying the cellular response in various conjunctival disorders. A round plastic disc (Thermanox) is pressed against the patient's conjunctive, and the material adhering to the disc is stained with a modified Wright's stain (Diff-Quik) for light microscopy. This method compares favourably with the classic conjunctival scraping method. The advantages of the impression technique are that no local anesthetic is needed for abtaining conjunctival samples, it is painless and can readily be used in children, repeated samples can be taken within a short time, the staining procedure can be completed within 15 seconds, and the discs can be processed for electron microscopic studies of the cellular samples.
Investigation to determine the cause of vomiting in a 14-mo-old child revealed partial obstruction at a narrowed segment of mid small bowel, with local deficiency of circular muscle and ballooning proximally. The pathogenesis of this apparently unique lesion is uncertain.
A review of 33 infants treated over 25 years for benign sacrococcygeal teratoma shows that this is predominantly a newborn tumour presenting mostly as an external mass and carrying an excellent prognosis provided surgical treatment is prompt and complete excision accomplished. Resectability was 100% in this series as is usually the case. This tumour must however, be differentiated from other masses presenting in the sacrococcygeal area by a careful histologic study since these other lesions generally require a different therapeutic approach.
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At the Hospital for Sick Children 177 patients with lymphangioma, exclusive of those who had intra-abdominal lesions, were seen between 1927 and 1964. Forty-nine of these (aged 8 to 41 years) were available for follow-up examination. The results of treatment by surgical excision, aspiration, incision and drainage, and radiation are reported. No cases confirmed histologically as lymphangioma underwent spontaneous regression. Two histologically unconfirmed cases underwent partial regression. Four of the 11 who were left with lymphangioma tissue at operation never had significant recurrences. Therefore, this clinical study does not clarify the possible role of spontaneous regression in lymphangioma. Extensive surgery is the treatment of choice whenever feasible, but in unilocular or bilocular cystic lymphagnioma subsequent regression can be expected after palliative treatment (aspiration, or incision and drainage). Clinical and pathological criteria should be established for differentiation between lymphangioma and primary lymphedema. Lesions involving subepithelial, subdermal, and subcutaneous or internodal networks of lymphatics will produce lymphagioma; lesions of the collecting lymphatic trunks will result in lymphedema.
In a retrospective study of primary lymphedema, we found that the age of onset ranged from 0 to 16 years; sex did not appear to be a factor; and treatment was preventive rather than surgical. Thirteen patients were available for follow-up studies, the time interval being at least 6 years. The degree of swelling at the time of the follow-up examination was defined as mild, moderate, or severe. In patients with mild and moderate swelling the edema was not progressive and surgical treatment was not indicated. Severe swelling appeared to be associated with congenital lymphedema and with repeated infection. Pressure-support treatment can be effective in the reduction of swelling or in the prevention of further swelling, if applied constantly over a long period of time. The authors discuss the histological similarity between lymphedema and lymphagioma, and present an anatomical classification for the two entities.
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A 5-year-old boy with a painful lesion in the proximal humerus is reported. Plain radiographs suggested the presence of a malignant bone lesion, and CT showed features similar to stress fractures. Pathologically, the changes were that of reactive periostitis.
A 12-year-old girl presented with an isolated soft tissue recurrence of chondromyxoid fibroma after two previous excisions of tumor from the proximal tibia. Chondromyxoid fibroma is a rare benign tumor of bone. We present this case report of isolated soft tissue recurrence to emphasize a rarely reported complication of surgical extirpation.
A very rare combination of two rare entities is reported. The patient had anterior sacral and intrasacral meningoceles, which were repaired at age 3 years, and 7 years later he presented with hypopituitarism due to a suprasellar teratocarcinoma. There has been no evidence of tumor recurrence in the 2.5 years since subtotal excision and radiotherapy (patient was last seen in 1977). Two aspects of the case are reviewed: the unusual nature of the spinal defect and the implications of its association with an intracranial tumor of developmental origin.
A technique is described for an extracorporeal arteriovenous shunt in dogs which allows the testing of biomaterials in the shunt for several months in the same animal. The details of the preparation of the tubes and of the surgical technique are given. In contrast to other techniques, encircling ligatures are not placed around the cannulated blood vessels.