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Biomedical subjects

K Mang

Publications and source records attributed to K Mang.

25 records · Page 2Linked to original sources

Delayed seroconversion to HIV in a hemophiliac.

In a 14-year-old boy with severe hemophilia B, HIV seroconversion was observed about 2 years after substitution therapy had been changed to heat-treated PPSB concentrates. This shows that HIV-antibodies may appear in hemophiliacs after time periods longer than generally assumed.

Acquired Immunodeficiency Syndrome↗

[Procedures in fulminant courses of necrotizing enterocolitis].

14/42 neonates suffering from N.E.C. developed the clinical stage III (intestinal necrosis, septicemia) and/or IV (intestinal perforation, peritonitis) within 24-48 h ("fulminant" course). 2/14 deteriorated dramatically and died before operation. In 12/14 cases, the general condition could be improved and immediate laparotomy was performed (2/12 died). Management and factors affecting prognosis are discussed. Following surgery, there was no significant difference in survival rates between "fulminant" and protracted course N.E.C.

Combined Modality Therapy↗

[Neonatal blennorrhea caused by Chlamydia trachomatis].

Chlamydial conjunctivitis was diagnosed in a 5-day-old male newborn. Under treatment with erythromycin the clinical picture of intense swelling of the lid and the copious purulent discharge abated during the following 2 days. Chlamydia trachomatis has become worldwide the most prevalent causative agent of neonatal conjunctivitis.

Bacteriological Techniques↗

Systemic arterial hemodynamics in the diamond python Morelia spilotes.

Studies of pulsatile systemic arterial hemodynamics were conducted in 10 diamond python snakes to test the hypothesis that body shape--through spatial dispersion of peripheral reflecting sites--is an important determinant of impedance patterns and of pulse wave contour. Findings support the hypothesis. Flow patterns in the aortic roots were similar to those in humans, sheep, dogs, rabbits, and guinea pigs, but in contrast to larger animals, little change in flow contour was seen in other arteries. Pressure wave contour was similar in all systemic arteries from which records were taken with no secondary diastolic wave under any circumstances. Impedance patterns at different sites showed none of the fluctuations that in other animals are attributable to discrete wave reflection. Discrete proximal wave reflection at the confluence of aortic arches was minimal. Data are explicable on the basis of widely distributed peripheral reflecting sites--a consequence of the snake's long and tapered body.

Animals↗

A comparative study of pulsatile arterial hemodynamics in rabbits and guinea pigs.

Pulsatile pressure and flow were measured in the ascending aorta and other arteries of 22 anesthetized rabbits and 16 anesthetized guinea pigs. Pressure/flow relationships were expressed as vascular impedance. Aortic flow waves were almost identical in the two species, but pressure waves were quite different. Reflected pressure waves returned earlier from the periphery in guinea pigs, augmenting pressure during late systole and resulting in relatively high external left ventricular work, an inappropriately larger difference between mean systolic and mean diastolic pressure and absence of any aortic diastolic pressure wave. Values of impedance modulus and phase were similar but differed in the frequency at which maxima and minima occurred. In both species, impedance curves were interpreted to indicate a functionally discrete reflecting site in the lower body whose position corresponded to the region of the aortic bifurcation. In addition, rabbits showed evidence of an upper body reflecting site approximately one-third as far distant from the heart. As in dogs, the arterial system in both species can be represented by an asymmetrical T-shaped model of realistic dimensions.

Animals↗