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Biomedical subjects

K Marsot-Dupuch

Publications and source records attributed to K Marsot-Dupuch.

At least 19 recordsLinked to original sources

Lethal midline granuloma: impact of imaging studies on the investigation and management of destructive mid facial disease in 13 patients.

In 13 patients presenting as lethal midline granuloma (LMG), computed tomography proved essential for determining the extent of the disease, guiding biopsy and planning radiotherapy. Magnetic resonance imaging (MRI) was also helpful for the latter, because it could distinguish fluid retained within the paranasal sinuses from solid masses and tumour from granulation tissue; it was of little value for detecting bone lysis. Eight of the 13 patients proved to have T-cell lymphoma, two had Crohn's disease, in one the lesion was factitious and two had granulomas without diagnostic histological features.

Adult

[Osteitis of the base of the skull].

The base of the skull and calvarium may be the site of osteitis secondary to haematogenous or loco-regional dissemination of a nasal sinus or postoperative, external ear or middle ear infection. Although most of the complications of osteitis are eradicated by antibiotics, some persist and are still serious due to the delay in the diagnosis extensive necrosis due to the bacteria and the clinical context.

Anti-Bacterial Agents

[Diagnostic orientation and radiological assessment of anosmia].

The olfactory system is made up of the olfactory epithelium, bulbs and tracts, together with olfactory areas in the brain. Anosmia may results from benign and malignant nasal sinus lesions, but also from lesions involving the CNS structures involved in olfaction. The purpose of this article is to review the different diagnose of anosmia and their CT or MR imaging characteristics.

Brain Neoplasms

[Retrograde perineural extension of a metastatic recurrence of a frontal skin tumor].

Perineural metastatic spread of malignant tumours has been described for a long time, but has only recently been demonstrated by medical imaging. MRI, guided by the clinical findings, with fine sections on T1-weighted sequences without and with gadolinium, allows the diagnosis of this type of spread. The tumours most frequently responsible are squamous cell carcinomas and cylindromas. The trigeminal and facial nerves are the most frequently affected. Recognition of such lesions is essential in the initial staging of a malignant tumour of the face, as it alters the therapeutic strategy.

Cranial Nerve Diseases

[Epidermoid cyst of the base of the skull].

Epidermoid cysts are rare congenital tumours representing less than 1% of all intracranial tumours. They are derived from the development of abnormally situated ectodermal tissue and are often an incidental finding. We report a case confined to the base of the skull, responsible for an extradural mass.

Adult

[Unusual localization of an olfactory esthesioneuroma].

Olfactory neuroblastoma, a nerve tumour arising in the olfactory mucosa, is a relatively easy diagnosis in the case of a mass centered around the cribriform plate. It is more difficult to diagnose in its exceptional ectopic forms (maxillary sinus) in the absence of any cytological and histochemical arguments (fibrils, olfactory rosettes). Its local malignancy is variable with a 42% 5-year survival for stage C and metastases in 30% of cases (principally cervical nodes, bone and liver). The role of imaging is to define the criteria of a mass syndrome and to perform the preoperative staging in a case of apparently simple sinus obstruction.

Brain Neoplasms

[Magnetic resonance imaging of neurofibromatoses].

Neurofibromatosis is classified into two types. Type 1, NF1 or von Recklinghausen's disease, consists of skin and bone lesions as well as central nervous system tumours arising at the expense of glial tissue: optic tract gliomas, glioblastomas, astrocytomas and "hamartomas". Type 2 consists almost exclusively of CNS tumours arising at the expense of nerve envelopes: Schwannomas, meningiomas.

Adult

[Unusual localization of a recurrent benign parotid tumor in the infratemporal fossa].

Recurrences of parotid tumours are frequent (10 to 20% of cases) and require regular follow-up of these patients, especially when primary surgery was only partial and the initial tumour was multinodular. Malignant degeneration is reported in 1% of these tumours. The site of a parotid tumour in the infratemporal fossa is exceptional and usually indicates a malignant tumour metastasising along the internal maxillary artery and auriculotemporal nerve, as the inter-pterygoid aponeurosis is very resistant. However, this is no longer true following primary surgery in which damage to this aponeurosis is responsible for dissemination or localisation of the recurrence in the infratemporal fossa. The infiltrated appearance of the skin, muscles or fat is not suggestive of a malignant tumour and this dissemination can be explained by the multinodular and invasive potential of this tumour.

Female

[Atypical osteomyelitis of the base of the skull and malignant otitis externa].

Osteomyelitis of the skull base is a rare, but serious disease whose incidence is tending to increase. It affects the marrow of the temporal, occipital and sphenoid bones and is generally secondary to Pseudomonas aeruginosa infection of the external auditory meatus. Based on a clinical case, the authors recall the difficulty of establishing the positive diagnosis and the possible confusion with neoplastic disease, hence the fundamental role of biopsies. They also review the literature on this subject.

Aged

[The middle third of the face in facial lift: lipopexy of the premalar fatty pad].

UNLABELLED: The technique proposed tries to resolve an irritating problem which has been incompletely and illogically resolved until now: the restoration of the natural relief of the middle third of the face. An anatomical study shows that the malar region is an eminence composed of a double structure, bony and fatty. The ptosis of what the authors propose to call "the premalar fatty pad" is probably the earliest sign of ageing in the face. It give a skeletal appearance and fills the canine fossa which become a heavy fold and increases the apparent depth of the naso genio labial sulcus. The aim of this technique is to restore a normal appearance by restoration of the true anatomical structures. The technique consists of extensive undermining behind the ptotic fatty pad, in front of the malar bone and SMAS as fas as the orbital rim which allow displacement upwards and backwards. Resorbable sutures and an accurate skin tension ensure the new premalar position of the fatty pad. Posterior fibrosis, in the undermining, will be the essential means of late fixation. 70 such operations with sufficient follow up have been carried out. The result is stable in 58 of them and insufficient but appreciable in all of the others. Fatty faces give poor results due to the poor quality of the skin. CONCLUSIONS: it is a simple, logical and efficient procedure, more often performed in association with the treatment of frontal and cervicofacial level of the face. No complications related to this procedure have been observed.

Adipose Tissue

[3D imaging of the labyrinth: application to candidates for cochlear implant].

Cochlear implantation is a treatment for profound bilateral cochlear hearing loss. Two broad varieties of cochlear implants are used: single or multichannel device (22- channel) inserted either into the cochlea (tympanic ramp) or on the promontory on round window Imaging modalities have to predict cochlear patency prior surgery, an essential factor for choosing between intra or extra cochlear implant. Since March 1991, we have investigated 23 implant candidates to evaluate cochlear patency prior surgery, 6 patients underwent surgery: 4 had a multichannel and 2 had a monochannel electrode. Both CT and MRI play a role in pre operative study. CT easily predicts cochlear ossification and labyrinthine malformations MRI (3 D applications) with T 2 Weighted images, one millimeter thick, more clearly depicts labyrinthine liquid and can predict cochlear fibrosis before ossification.

Cochlear Implants

[Subcondylar mandibular fracture].

Mandibular fractures are frequent lesions which are classified into 6 groups according to the site of the fracture. Condylar fractures are primarily due to a direct blow to the symphysis menti. Medical imaging must be able to identify the type of fracture, its intra- or extra-articular site and the associated displacement of the condyle, the fundamental element in deciding treatment. The action of the masticatory muscles on one of the bone fragments may be responsible for an unstable fracture, leading to disturbances of consolidation (pseudarthrosis). Anterior bilateral fractures can be life-threatening due to ptosis of the tongue.

Adult

[Cholesterol granuloma. Review of the literature apropos of a case].

MRI allows the diagnosis of cholesterol granuloma in the presence of a non contrast-enhanced, erosive solid mass of the apex of the petrous bone or middle ear. Cholesterol granuloma has a suggestive low signal intensity on T1 and T2 weighted sequences (cholesterol crystals, haemoglobin degradation products). These specific features eliminate the principal CT differential diagnoses, particularly cholesteatoma. MRI is also useful for follow-up of treatment.

Cholesterol

[Malignant external otitis. When and which imaging].

Malignant external otitis (MEO) is a severe infection of the external auditory canal (EAC), most often caused by Pseudomonas aeruginosa, although a few cases are caused by an Aspergillus (4). Mortality remains high (20%) in spite of an early general antibiotic treatment. This infection of the soft tissue of the EAC causes cellulitis, chondritis and osteomyelitis, and there are risks of diffusion into the base of the skull. Our work is aimed at placing computed tomography and magnetic resonance imaging into the context of exploration of this infection, in relation to radionuclide scanning, owing to our experience with 10 patients. Imaging appreciates the anatomical extension of the infection beyond the EAC and towards the base of the skull and the infratemporal fossa, this being a key element for prognosis. It assesses the efficiency and duration of treatment, although the criteria of healing are still difficult to appreciate and late recurrence is frequent. Exceptionally, it is useful for diagnosis in some particular clinical forms.

Adult

[Parotid metastases: value of imaging. Review of the literature, apropos of 4 cases].

Parotid gland is a very unusual site of metastasis. Four proven cases are described. The tumor was occult in three cases out of four. In one case, an extra neck primitive tumor was suspected. Two kinds of metastases are described: firstly, metastases within the salivary gland with look like pleomorphic adenoma and are secondary to hematogenous spread; secondly, lymph node metastasis (two cases). Their diagnosis appear easier as they are not usually completely surrounded by parenchyma. They can reveal either occult head and neck tumor or visceral tumor.

Adult

[Echography of the parotid gland].

Ultrasound is the first choice imaging modality for the evaluation of parotid lesions because of its simplicity and its sensitivity which is as high as that of a CT scan. It can differentiate between benign and malignant tumors. However MRI is necessary for the exploration of the deep lobe, regional spread and a better histopathologic differentiation.

Humans