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Biomedical subjects

K Mashimo

Publications and source records attributed to K Mashimo.

23 records · Page 2Linked to original sources
PubMed1976

[Pharmacokinetics in constant drip infusion of cephaloridine-Lilly (author's transl)].

The serum and urinary levels and urinary recovery of cephaloridine during and after two-hour drip infusion of 1 or 2 grams of cephaloridine dissolved in 500 ml of physiological saline solution were determined in four healthy volunteers in cross-over fashion. Using the values of serum levels obtained from this experiment, pharmacokinetic parameters were calculated and simulation curves of serum levels for various doses and durations of cephaloridine drip infusion were drawn.

Adult↗
PubMed1975

[Studies on the absorption and excretion of doxycycline for intravenous use (author's transl)].

The absorption and excretion of a new doxycycline solution for intravenous use (DOTC iv) were studied with the following results. 1. Serum levels following one shot intravenous injection of DOTC iv in glucose solution showed a good dose-response comparable with that of the same dose injection of pyrrolidinomethyltetracycline (PRM-TC). The urinary excretion was also examined. In 200 mg injection, nausea, general warm feeling, odor in mouth and tongue numbness were complained. 2. When DOTC iv was injected intramuscularly, the serum level did not reach the peak value and low level continued for a long time. Moderate local pain was complained at the site of injection. 3. The serum level following drip infection of DOTC dry fill showed a dose-response as well. The local vein tolerated well. 4. No abnormalities were found in clinical and laboratory examinations in all volunteers.

Adult↗
PubMed1975

Combination therapy of anti-endotoxin antibody and gentamicin in the immunosuppressed mice with Pseudomonas aeruginosa infection.

Therapeutic effect of anti-endotoxin antibody in combination with or without an antibiotic, gentamicin, was studied in DD-strain mice experimentally infected with Pseudomonas aeruginosa. Mice were treated by various immunosuppressive agents such as 60Co irradiation, cyclophosphamide, azathioprine or cortisone acetate prior to infection. Anti-endotoxin antibody was made in mice by immunization with original endotoxin protein (OEP). F(ab')2 fragment of IgG prepared from pooled immune sera was administered intravenously without side effects. Large dose of the antibody resulted in remarkable therapeutic effect even in absence of the antibiotic. Small dose of the antibody enhanced the therapeutic effect of gentamicin. Differential effect of the immunosuppressants for T and B lymphocyte populations was examined by anti-theta cytotoxicity test. Resistance of DD-strain mice to P. aeruginosa infection was not related to these lymphocyte population changes.

Animals↗