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Biomedical subjects

K Masuko

Publications and source records attributed to K Masuko.

At least 73 records · Page 4Linked to original sources
PubMed1977

Cephalosporins. II. 7-(O-Aminomethyl-phnylacetamido) cephalosporanic acids with six membered heterocycles in the C-3 side chain.

7-(o-Aminomethylphenylacetamido)cephalosporanic acids with six-membered heterocycles in the C-3 side chain were prepared by nucleophillic substitution of 7-ACA at the C-3 acetoxy group followed by N-acylation of the 7-amino group. The 7-side chain acid, o-aminomethylphenylacetic acid (5), was prepared by two new convenient routes, which involved Schmidt reaction of indanone (2) followed by cleavage of the lactam ring or reduction of o-cyanophenylacetic acid (10) starting from o-nitrotoluene. The antibacterial activity of the cephalosporins in this series depends on the heterocycle in the C-3 side chain. In general pyridazines gave cephalosporin derivatives possessing better activity than those with a pyridine or pyrimidine ring. The most active member of the new cephalosporins was 7-(o-aminomethylphenylacetamido)-3-(6-hydroxypyridazin-3-ylthilmethyl)-3-cephem-4-carboxylic acid (BB-S 150) (1g) which has in vitro antibacterial activity superior to cephalothin and cefazolin against both gram-negative and gram-positive organisms. The in vitro activity of BB-S 150 determined in mice was superior to cephalothin and comparable to cefazolin.

Animals↗
PubMed1976

Interactions of human cord dorsum potential.

The slow positive wave (P2 wave) of the evoked spinal electrogram was recorded from the posterior epidural space in wakeful man, and studied by applying several modes of peripheral nerve stimulation. With graded stimulation the P2 wave amplitude rapidly reached the maximum at weaker stimulation than that required for the initially positive spikes (P1) and the preceding negative (N1) wave. The "second" component of the P2 appeared during stronger stimulation or during excitemenpt of the subjects. With prolonged repetitive stimulation the P2 wave increased its duration with several summits on the decaying phase. Two interactions were observed between the P2 waves produced by conditioning and testing stimulations in the same or different nerves: inhibition or occlusion by strong stimulation and faciliation by weak stimulation. Thus, the characteristic of the P2 wave in man was similar in part to that of the positive wave observed in decerebrate animals, and differnt in other ways presumably due to influences from supraspinal structures or species differences.

Adult↗
PubMed1976

[Nursing procedures for cynomolgus monkey infants (author's transl)].

This paper describes the results of the artificial nursing of 8 infant cynomolgus monkeys (Macaca fascicularis) weighing 230-350 g at birth. The infants were separated from their mothers just after or 2 days after birth and were kept in a specially deviced small cage (Photo 1 & 2). They were fed on 6.4-16.6% solution of a commercially available powdered milk for the human baby. Apple juice also was given to them from the 3rd or 4th week on. In about the 6th week, the infants received solid foods such as small pieces of apple, biscuit and monkey chow. The main part of the dietary regimen was changed to the solid diet around the 12th week. The volume of milk taken was recorded every day, and the daily intake ff three major nutrients was estimated with the milk intake (Fig. 1,2,5,6). The body weights were between 600 and 750 g on the day of weaning, that is at about 12 weeks of age, except No. 2 infant showing a slight growth retardation (Fig.4). Their physical growth can be judged as normal as that of breast-nursed infants of the saame species from our laboratory. On the basis of these results, an example of the artificial feeding schedule for the infant cynomolgus monkeys was introduced (Fig. 7).

Animal Feed↗