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Biomedical subjects

K Matousovic

Publications and source records attributed to K Matousovic.

At least 19 recordsLinked to original sources
PubMed1992

[Long-term prognosis in chronic primary glomerulonephritis in relation to urinary findings].

A long-term followed-up group of 993 patients with primary glomerulonephritis (GN) was divided by urinary syndromes, defined according to the degrees of proteinuria and haematuria. Responding morphological diagnoses and prognoses were found for each urinary syndrome. Isolated and predominant haematuria were determined as benign, with stationary course even without immunosuppressive therapy. The prognosis of isolated, even moderate, proteinuria is more serious finding. Its relevance increases with the degree of haematuria. Severe combined proteinuria and haematuria is the most serious urinary syndrome. Both proteinuria and haematuria may be changing in the course of GN and increasing proteinuria points to the future glomerular filtration rate decrease.

Chronic Disease↗
PubMed1992

[IgA nephropathy. Morphology, clinical picture and significance of mesangial fibrin deposits].

IgA nephropathy was diagnosed in 114 biopsies from 107 patients comprising 78% men. Light microscopy revealed most frequently mild proliferative glomerulonephritis with frequent though rudimentary extracapillary proliferation (in one quarter of the biopsies). Allergic manifestations in the case-history were recorded in 14% of the patients. Almost in one third of the patients the disease started by macroscopic erythrocyturia. A typical finding in urine was predominating erythrocyturia (tens of millions in Addis sediment) over proteinuria (usually less than 1.5 g/24 h). Cumulative "renal survival rate" ten year after biopsy was 84%, the cumulative ratio of remissions was 30%. Mesangial fibrinoid deposits were found in half the patients with a severe course of the condition.

Adult↗
PubMed1991

[Clinical picture of 11 patients with sponge kidney].

The authors review clinical data assembled in 11 patients with sponge kidneys followed up for prolonged periods. The disease is manifested by colics, haematuria and symptoms of bacterial inflammation of the urinary pathways. The basis of the diagnosis is excretory urography with typical changes in the renal pyramids: cystic dilatation of the collecting tubules, calcifications and concrements. The main functional disorder is a decline of the concentrating capacity of the kidneys. In some patients renal tubular acidosis of the distal type can be proved.

Adolescent↗
PubMed1990

[Type I and III membranoproliferative glomerulonephritis. Clinical picture and prognosis].

Membranoproliferative glomerulonephritis (CN) of types I and III was diagnosed in 154 patients (15.5% out of primary CN). Out of this number 60% were men. During biopsy, one third of the patients were normotensive, 40% were slightly hypertensive and one third suffered from severe hypertension. Mean proteinuria was 6.5 +/- 5.5 g/24 h. In two thirds of the patients erythrocyturia was higher than 35 mil. in Addis' sediment and the findings in the urine were characterised by the proportion between proteinuria and erythrocyturia (p less than 0.001). During biopsy in one half of the patients, the serum creatinine level was already elevated. The presence of creatininemia was found to be directly linked to blood pressure, proteinuria, the degrees of extracapillary proliferation, tubulointerstitial regression and vascular arteriolosclerosis. The cumulative duration of the kidney function within the period of 10-20 years was 41 or 28%, the cumulative cure amounted to 14% 10 years after biopsy.

Adolescent↗
PubMed1990

[Long-term effect of the administration of repeated single doses of netilmicin in urinary tract infections].

In 26 patients with different clinical forms of infections of the urinary pathways a 300 mg single dose of netilmicin was administered by the i.m. route and the bacteriological urinary finding was checked for as long as 10 weeks after administration of netilmicin. During this period the urine was bacteriologically negative in 42% of the subjects. In 8 subjects with relapses of the infection a second dose of 300 mg netilmicin was administered and the urine was bacteriologically negative for 10 weeks in four of the patients. On the whole it proved possible to eliminate the urinary infection for 42-112 days in 17 subjects (65%), even in so-called complicated infections. It may be stated that single dose treatment with netilmicin used once or repeatedly leads to prolonged elimination of the infection without affecting the sensitivity of the organisms, without side-effects and with a substantial reduction of the cost of treatment.

Adult↗
PubMed1990

Comparison of three dosage regimens of ciprofloxacin in urinary tract infections.

Fifty-four patients with complicated UTI were administered ciprofloxacin in doses of 500 mg (30 subjects) and 250 mg (24 subjects) at 12-hour intervals. While a positive effect was noted in 96-100% upon termination of therapy, the effect was still present 3 weeks later in 90% of the high-dose, but only in 71% of the low-dose group. In 23 patients with uncomplicated UTI, a positive effect of the three-day therapy with 100 mg of ciprofloxacin at 12-hour intervals was observed in 91% of subjects. Intolerance to the agent was found in one case only. Development of resistance to ciprofloxacin was not observed.

Adult↗
PubMed1990

Experimental ablation nephropathy. Fine structure, morphometry, cell membrane epitopes, glomerular polyanion and effect of subsequent transplantation.

The subtotal (5/6) nephrectomy performed in 23 adult female rats induced severe hypertrophy of residual parenchyma with interstitial fibrosis, tubular dilatation, and focal and segmental glomerulosclerosis (FSG). This ablation nephropathy (AbN) caused proteinuria, progressive renal failure, and hypertension. The extent of FSG was assessed by semiquantitative scoring. The ultrastructure revealed widespread foot process fusion, many dense cytoplasmic inclusions in podocytes, and degenerative changes or disruption of mesangium with glomerular "microcysts". Numerous granular deposits of rat Ig were seen in the glomeruli but a short praeterminal i.v. load by heat-aggregated human Ig did not alter the morphology of AbN and produced discrete and inconstant glomerular deposits. Similarly an i.v. injection of protamine and heparin generated protamine-heparin complexes seen in various layers of glomerular capillary wall, similar to those found previously in normal rats. AbN displayed a partial irregular depletion of polyanion sites reactive with polyethylenimine in lamina rara externa. A significant increase in both glomerular and interstitial Ia+ cells and a marked predominance of W3/25+ cells in the interstitial infiltrates were documented by immunohistochemistry in the remnant kidneys. Both AbN and FSG could be largely corrected (or prevented?) by subsequent syngeneic renal transplantation (TPL; 6 animals). On the other hand a severe AbN was found in two post-ablation residues after unsuccessful TPL with graft necrosis or sclerosis.--AbN has some analogies to various chronic human nephropathies (e.g. FSG) and may explain their progression to the terminal failure. Degenerative and finally destructive mesangial lesion seems to be of prime importance in AbN.

Animals↗
PubMed1990

Pharmacokinetics of roxithromycin in kidney grafted patients under cyclosporin A or azathioprine immunosuppression and in healthy volunteers.

The pharmacokinetics of roxithromycin was studied in 9 kidney grafted patients under cyclosporin A immunosuppression, in 10 transplanted patients with azathioprine, and in 6 healthy volunteers. The biological half-life (beta-phase) of roxithromycin in cyclosporin patients was 34.4 (+/- 12.25) h (mean +/- SD), in azathioprine patients 23.4 (+/- 8.18) h and in healthy volunteers 17.0 (+/- 3.8) h. The total elimination constant (k10) was 0.046 (+/- 0.014), 0.068 (+/- 0.019) and 0.084 (+/- 0.036) h, respectively. The total clearance was 0.79 (+/- 0.21), 1.45 (+/- 0.66) and 1.84 (+/- 0.56) l/h, respectively. The areas under the serum level curves were 407.6 (+/- 118.3), 251.0 (+/- 106.6) and 180.7 (+/- 73.2) mg.h/l, respectively. The differences in these parameters between healthy volunteers and cyclosporin patients were statistically significant, as well as those between cyclosporin and azathioprine patients. The differences between healthy volunteers and azathioprine patients were not statistically significant. The results cannot be interpreted unambiguously as an interaction between roxithromycin and cyclosporin; the effect of cyclosporin on the function of eliminating organs which causes the slowed-down elimination of roxithromycin could be taken into account.

Adult↗
PubMed1989

[Idiopathic membranous glomerulonephritis. Clinico-morphologic relations and prognosis].

Membranous glomerulonephritis (GN) was diagnosed in 61 of 993 patients with histologically confirmed primary GN. Two-thirds of the patients were men. High hypertension was recorded in 7.5% of the patients. A typical finding was marked proteinuria (6.15 +/- 4.88 g/24 h.) with mild erythrocyturia (median 8 million in Addis sediment). At the time of biopsy 86% of the patients had normal creatininaemia, the level of which was positively correlated with the blood pressure and degree of tubulointerstitial regression. The cumulative duration of renal function in 5, 10 and 20 years was 88, 80 and 57%; during the same time intervals 22, 48 and 52% of the patients were cured.

Adult↗
PubMed1989

[Prevention of recurrent urinary infections using Solco Urovac, a polymicrobial vaccine].

The administration of Solco Urovac polymicrobial vaccine to 26 patients with recurrent episodes of urinary tract infection significantly reduced the number of episodes, in one third of the persons even prevented them for a period of one year. In case of persistent bacteriuria, accompanying, for example, nephrolithiasis, the vaccine had no effect. A better effect can be achieved in cases of uncomplicated infections of the lower urinary tract than in infections associated with structural abnormalities of the kidneys and urinary tract. In some patients, the administration of the vaccine is accompanied by mild side effects which, but only exceptionally, can lead to the discontinuation of the therapy.

Adjuvants, Immunologic↗
PubMed1989

[The effect of diphenylhydantoin on IgA nephropathy].

Seventeen patients with verified diagnosis of IgA nephropathy (15 men and 2 women) were divided into two groups using random selection. The group receiving treatment consisted of 9 persons, the control group was made up of 8 persons. The former group were given diphenylhydantoin in doses of 2-3 mg/kg/day for a period of 6 months. After the termination of the course of treatment, the authors found a drop in the levels of serum immunoglobulins A, G, complement components C3, C4, circulating immunocomplexes, and decreased haematuria, and, in contrast, increased levels of serum creatinine. No undesirable effects of diphenylhydantoin were noted.

Adult↗
PubMed1989

Effect of methylprednisolone therapy on lipoprotein metabolism in human nephrotic syndrome.

Changes in the lipoprotein metabolism of 15 patients with nephrotic syndrome concomitant with various types of the underlying renal disease after methylprednisolone therapy were investigated. Following methylprednisolone therapy, nephrotic syndrome remission was achieved only in three patients with minimal change disease. In these patients, total cholesterol (TC) and free cholesterol (FC) decreased and an increase in HDL-C and the HDL-C/TC ratio was found. In the remaining 12 patients, while marked proteinuria persisted after therapy, a significant increase in HDL-C (from 1.38 to 1.83 mmol/l) was noted with no significant changes in TC, FC and TG. Our results suggest that methylprednisolone may affect lipoprotein metabolism without necessarily exerting a favourable effect on the course of kidney disease.

Adult↗
PubMed1989

Changes in renal haemodynamics in the nephrotic syndrome.

It has repeatedly been found that haemodynamic changes during hypoproteinaemia in the chronic phase of the nephrotic syndrome are different from those during hypoproteinaemia in the acute phase. In our series of patients, a decrease in the filtration fraction and relative hyperperfusion of the kidneys were associated with the presence of the nephrotic syndrome. No significant changes in renal haemodynamics were observed in patients with chronic glomerulonephritis without the nephrotic syndrome or in a group of healthy volunteers. The question of whether relative hyperperfusion of the kidneys in a repeatedly relapsing nephrotic syndrome can lead to the development of focal segmental glomerulosclerosis needs to be elucidated.

Acute Disease↗