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Biomedical subjects

K May

Publications and source records attributed to K May.

9 recordsLinked to original sources
PubMed1992

Preparation of the renal function and imaging agent 99mTc-MAG3 starting from S-unprotected mercaptoacetyltriglycine.

A new approach that obviates inconvenient heating of the labelling solution when preparing the renal function and imaging agent 99mTc-MAG3 is described. The labelling procedure involves reduction of 99mTc-generator eluate with stannous chloride in alkaline solution in the presence of S-unprotected mercaptoacetyltriglycine (MAG3) and the co-ligand sodium tartrate, followed by neutralization with a phosphate buffer solution. After optimization of the kit preparation the radiochemical purity of the radiopharmaceutical amounts to greater than 98%. During the labelling process intermediate Tc-species occur.

Oligopeptides↗
PubMed1991

Home tests to monitor fertility.

Industry has been intimately involved in the development of products used in the monitoring of fertility at home. The perspective of industry and the development of such tests including their rationale are presented. The methods taken by industry to utilize current technology in the development of reliable, rapid, one-step tests for urinary human chorionic gonadotropin and luteinizing hormone and the subsequent expansion into other areas are covered.

Antibodies, Monoclonal↗
PubMed1991

Evaluation of effectiveness and tolerability of isosorbide mononitrate during a three-year period in patients with angina pectoris.

The antianginal effect and tolerability of isosorbide mononitrate (ISMN), 20 mg 2-3 times daily, orally were investigated in an open study in 28 patients, suffering from coronary heart disease and stable angina pectoris. Ergometric exercise tests were carried out before treatment and 2 h after drug intake, every 3 months during the first year and at 6-month intervals during the following 2 years. At the conclusion of the 3-year study the reduction of ST-segment depression, which had amounted to 58% after 1 year, could be improved to 78% (p less than 0.01). The frequency of angina was markedly reduced during the treatment with ISMN. While 14 of the patients had more than 3 episodes per day prior to the study, 16 patients were symptom-free at the end of the three years' therapy, and none of the patients had more than 1 or 2 attacks per day. The consumption of sublingual nitroglycerin diminished by 94% after one year and by 98% after 3 years of therapy (p less than 0.01). Headache was the only adverse effect observed in some of the patients (at the initiation of the treatment only). In conclusion this study demonstrated (1) the good tolerability of ISMN, at the doses used, and (2) the fact that the antianginal efficacy may be enhanced during the course of the therapy.

Adult↗
PubMed1990

Analysis of non-disjunction in sex chromosome tetrasomy and pentasomy.

X-linked DNA markers were used to determine the parental origin of the additional sex chromosomes in eight individuals with sex chromosome tetrasomy or pentasomy. In all cases studied, one parent contributed a single sex chromosome while the other parent contributed three or four sex chromosomes. Thus, it seems likely that most, if not all, sex chromosome tetrasomy and pentasomy is attributable to successive non-disjunctional events involving the same parent.

Female↗
PubMed1990

The parental origin of the missing or additional chromosome in 45,X and 47,XXX females.

We used X-linked DNA polymorphisms to study the parental origin of the missing or additional X chromosome in conceptuses with 45,X or 47,XXX chromosome constitutions. Fifty-three (80.3%) of 66 cases of sex chromosome monosomy had a maternal X, demonstrating that paternal sex chromosome loss is the most common error leading to this condition. In contrast, 29 (93.5%) of 31 47,XXX cases resulted from maternal nondisjunction. In studies of parental age, we detected no obvious parental age effect for sex chromosome monosomy. For the 47,XXXs, there was an apparent association between increasing maternal age and errors at maternal meiosis I, but not maternal meiosis II. In other analyses, we detected no obvious effect of parental origin on the phenotype of either 45,X or 47,XXX conceptuses, at least as measured by comparing the ratio of paternal:maternal errors among different ascertainment categories.

Aneuploidy↗
PubMed1979

Ferritin, a sensitizing substance in the leucocyte migration inhibition test in patients with malignant lymphoma.

The nature of the factor in Hodgkin's disease involved spleen to which many patients with malignant lymphoma react in the leucocyte migration inhibition test has been investigated. Our results suggest that ferritin from Hodgkin's disease involved spleens is antigenically different to that prepared from normal spleen. Isoelectric focusing shows the presence of more acidic 'isoferritins' in ferritin prepared from Hodgkin's disease involved spleen than in that prepared from normal spleen. Further observations using the leucocyte migration inhibition test suggest that sensitization to the abnormal ferritin, acting as an onco-fetal tumour associated substance, may be responsible for the reaction of patients with malignant lymphoma in this test.

Antigens, Neoplasm↗