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K McCabe

Publications and source records attributed to K McCabe.

22 records · Page 2Linked to original sources
PubMed1983

Secretory IgA synthesis in Kwashiorkor.

The synthesis of intestinal secretory IgA was studied in in vitro cultures of duodenal mucosal biopsies from children with Kwashiorkor. Production of secretory IgA was measured by the incorporation of radioactive label and visualized following PAGE and autoradiography. Results obtained before and after nutritional rehabilitation demonstrate an enhanced synthesis of sIgA in children with acute Kwashiorkor. Histological examination of plasma cells in the biopsy tissue confirms a twofold increase in IgA staining plasma cells in acute Kwashiorkor. Peripheral blood B lymphocytes in acute Kwashiorkor however, showed a reduction in IgA synthesis in the acute stage. These results suggest an effective mucosal sIgA response to the increased intestinal antigen load in Kwashiorkor.

Cells, Cultured↗
PubMed1981

Head and neck involvement with malignant histiocytosis: case report and literature review.

Malignant Histiocytosis (MH) is a disease being recognized with greater frequency. A case is reported together with a literature review to determine the frequency of this occurrence. Of the 108 case reports of MH reviewed, 43 (39%) had head and neck involvement described, with 22 (20%) having extranodal disease. Nine (40%) of the 22 cases with extra-nodal disease had primary involvement with an apparent survival advantage over the 13 (60%) with secondary involvement (12 mo. vs. 4 mo.). Although those with primary involvement may have apparently localized disease, systemic spread was eventually described in all case reports. Based on the above, MH should be considered as a diagnostic possibility in patients with head and neck lesions, and when diagnosed, systemic therapy should be administered even when the disease is apparently localized.

Adult↗