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K McGeeney

Publications and source records attributed to K McGeeney.

12 recordsLinked to original sources
PubMed1992

A new technique examines the connective tissue framework in normal testis and in testis cancer.

A method of cellular digestion known as Etching facilitated scanning electron microscopy (SEM) of the connective tissue framework in normal testis and in cases of testis cancer. The collagen in the seminiferous tubules in normal testis has distinct lamellae and a well-defined outer border. In the germ cell tumours examined, the tubular connective tissue appeared hypertrophied, the distinct outer border was maintained in a seminoma specimen unlike in a case of non-seminoma. In a specimen of non-germ cell lymphoma there was gross distortion of the tubular connective tissue. These apparent variations in the collagen framework may have implications regarding local tumour development.

Collagen↗
PubMed1990

The effect of caerulein induced pancreatitis on the hepatic microvasculature.

A three-dimensional morphological study of the hepatic microvasculature in caerulein induced oedematous pancreatitis was performed using scanning electron microscopy (SEM) vascular casts and transmission electron microscopy (TEM) of hepatocytes and hepatic sinusoids. TEM studies provided ultrastructural evidence of hepatocellular damage while SEM views demonstrated gross irregularity of the sinusoidal outline with abruptly terminating sinusoidal buds and extravasation of cast material, findings which were similar to those previously reported in the pancreas itself using the same model and which were supported by TEM cross-sectional views of the hepatic sinusoids. The results suggest that caerulein induced pancreatitis is associated with extrapancreatic microvascular damage which may be an important factor in the pathogenesis of extrapancreatic organ impairment associated with acute pancreatitis.

Amylases↗
PubMed1989

Three-dimensional morphological study of the pancreatic microvasculature in caerulein-induced experimental pancreatitis.

A morphological study of the pancreatic microvasculature in experimental pancreatitis was performed in dogs, using three-dimensional scanning electron microscopy vascular casting and transmission electron microscopy. Animals with pancreatitis were characterized by a marked reduction in the number of capillaries outlined by the cast and by distortion of those that were outlined, with irregularity of the capillary lumen, abruptly terminating capillary buds and leakage of the cast material through the capillary membrane. The study provides convincing morphological evidence that one of the earliest changes in acute pancreatitis is distortion of the capillary circulation.

Acute Disease↗