Bell's palsy, a discussion of treatment.
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Adrenocorticotropic Hormone↗
Biomedical subjects
K Mechelse
Publications and source records attributed to K Mechelse.
Hereditary sensory neuropathy, a new type.
Two brothers with a new type of hereditary sensory neuropathy are described. The main clinical feature is late onset sensory ataxia without ulcerating acropathy or other autonomic abnormality. The older patient also has oculomotor dysfunction and extensor plantar responses.
Ataxia↗
Role of tissue typing on preserved nerve allografts in dogs.
Histocompatibility seems to play an important role in the regeneration of nerve allografts. Compatible tissue typed nerve allografts behave more like autografts and are, therefore, more readily accepted by the host tissue without producing evident tissue rejection. The influence of histocompatibility difference becomes more marked if the graft is longer than 30-40 mm. Irradiation as a means of reducing the immune reaction of the nerve allografts does not seem to have any beneficial effect along with tissue typing. Preservation of nerve grafts at - 70°C does not have any untoward effect.
Animals↗
Nerve allografts and histocompatibility in dogs.
The histocompatibility requirements for successful frozen nerve allografts were studied in 46 dogs. Major canine histocompatibility (DLA) differences appeared to be of vital importance for nerve regeneration and function, as judged by histological and electromyographic performance 7 to 9 months after grafting. Minor histocompatibility differences did not appear to lead to rejection of the frozen nerve allografts. Graft irradiation did not improve the acceptability of frozen DLA-mismatched grafts. The effect of DLA matching was much more pronounced in allografts 7 cm long than in allografts 4 cm long. The results indicate the need for a bank of frozen human histocompatible (HLA) nerve allografts, and a study of the effect of partial or complete HLA matching on their survival.
Animals↗