Some patients undergoing endarterectomy for occlusive carotid artery disease run a risk of brain ischemia during cross-clamping of the artery. The present study of 15 patients was undertaken to evaluate changes in cerebral blood flow (CBF), as measured with an intravenous (IV) tracer (133Xenon) technique, and to relate CBF changes to changes in the electroencephalogram (EEG). CBF was measured before and after induction of anesthesia, during cross-clamping of the carotid artery, after release of the clamps, and at 24 hours after the operation. All the patients were anesthetized with methohexitone, fentanyl, and nitrous oxide and oxygen. EEG was continuously recorded during the operation. Carotid artery shunts were not used. In 8 patients, cross-clamping of the carotid artery did not influence the EEG. In this group of patients, induction of anesthesia caused a 38% decrease in CBF, which presumably reflects the normal reaction to the anesthetic agent given. There were no further changes in CBF during cross-clamping. In 7 patients, the EEG showed signs of deterioration during the intraoperative vascular occlusion. In these patients, anesthesia did not cause any CBF change, whereas cross-clamping the artery induced a 33% decrease in CBF. In individual patients, the severity of EEG changes correlated with the decrease in CBF. The absence of a change in CBF by anesthesia and a decrease due to cross-clamping of the carotid artery may be explained by the presence of a more advanced cerebrovascular disease and an insufficiency to maintain CBF during cross-clamping.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗

PubMedDate not supplied

Severe traumatic brain lesions in Sweden. Part I: Aspects of management in non-neurosurgical clinics.

This paper reports a study of 587 consecutive patients treated for severe traumatic brain lesions (coma greater than 6 hours) during 1977-1984. Epidemiology, management and outcome were documented in 425 patients during the first part of the study (1977-1982) as a basis for future efforts at improvements. A total of 70-80 patients with severe head injuries were admitted annually to the Department of Neurosurgery in Lund and 88.6% of these patients were referred from 14 local hospitals, most of which are situated more than 50 km from Lund. Half of the patients were older than 40 years and 25% older than 60. Focal intracranial mass lesions were diagnosed in 64% of the patients. In the total study 41% of the patients were described as 'talk and deteriorate' and 13% as 'talk and die'. In 1983 a protocol for primary management was introduced in all local hospitals in the region. The management protocol caused a significant decrease (p less than or equal to 0.05) in the number of explorative craniotomies in local hospitals and a virtual disappearance of late surgical procedures (greater than 6 hours after injury). A fall was observed in the number of patients arriving at the Department of Neurosurgery with respiratory insufficiency. The study illustrates the epidemiology of severe head injuries in Sweden and the present state of management of these patients in non-neurosurgical departments. It is concluded that an overall outcome comparable to other reported series is also feasible in regions with a relatively sparse population and large geographical distances provided that strict recommendations for initial management are given to the local hospitals.

Adult↗

PubMedDate not supplied

Severe traumatic brain lesions in Sweden. Part 2: Impact of aggressive neurosurgical intensive care.

During a 6 year period (1977-1982), 425 patients were treated in the Department of Neurosurgery, University Hospital of Lund, for severe traumatic brain lesions (coma greater than 6 hours). From 1983 a more aggressive management protocol was introduced including early recording of intracranial pressure (ICP) and 162 patients were included in the study 1983-1984. A dangerous increase in ICP in spite of adequate surgical treatment and moderately controlled hyperventilation was the incentive for barbiturate coma therapy in selected patients. In the first part of the study overall mortality was 48% whereas 39% of the patients reached good recovery/moderate disability 6 months after injury. During the second part of the study the corresponding figures were 35% and 54%, respectively (in both cases p less than or equal to 0.01). In the group of patients with focal intracranial mass lesions mortality decreased from 59% to 46% (p less than or equal to 0.05) and good recovery/moderate disability increased from 30% to 42% (p less than or equal to 0.05). Improvement in outcome was even more pronounced in patients with no-mass lesions, mortality decreased from 30% to 12% and good recovery/moderate disability increased from 56% to 80% (p less than or equal to 0.05 and p less than or equal to 0.01, respectively). No change occurred in age distribution or in the types of intracranial lesions that could explain these improvements. It is concluded that aggressive neurosurgical intensive care significantly improves outcome in patients with severe traumatic brain lesions.

Accidents, Traffic↗

PubMedDate not supplied

Severe traumatic brain lesions in Sweden. Part 3: Economic aspects of aggressive neurosurgical intensive care.

The present study had two main objectives: Firstly, to document the economic differences between 'ordinary' and 'aggressive' neurosurgical intensive care and secondly, to evaluate the medical benefits in relation to costs for different subgroups of head-injured patients. The study compares patients injured in traffic accidents and treated in the Department of Neurosurgery, University Hospital of Lund, during 1977-1978 (n = 67) with similar patients treated during 1983-1984 (n = 87) after introduction of more vigorous neurosurgical intensive care. The economic analysis was performed by means of the CRISE-method (Cost Related Index Score Evaluation) and all costs were related to the monetary value in 1984. Adoption of a program for 'aggressive' neurosurgical intensive care increased the costs per treated patient by about 46% (from 70.887 Swedish Crowns (SEK) to 103.452 SEK). Mortality decreased significantly after the change in intensive care and the cost per surviving patient remained virtually unaffected (131.928 SEK vs. 132.357 SEK). Further, after introduction of the 'aggressive' programme a larger proportion of the economic expenditures were spent on patients who ultimately recovered well. It is concluded that the increase in costs following introduction of a more vigorous intensive care programme in patients with severe traumatic brain lesions is very reasonable in relation to the documented medical benefits.

Accidents, Traffic↗