Biomedical subjects
Publications and source records attributed to K Mikołajczyk.
Eukaryotic ribosomal protein P0 is localized on the large ribosomal subunit at the base of the specific "stalk" structure, close to the central protuberance. Recently we have obtained a clone coding for P0 ribosomal protein from L. luteus (yellow lupin) cDNA library. Here we present its expression in E. coli cells and purification of the target protein.
Postoperative course in 12 patients which had laparoscopic adrenalectomy performed was compared with 8 underwent classic one in terms of operating time, blood loss, blood pressure recordings, C-reactive protein blood concentration, postoperative pain and hospital stay. The advantages of the laparoscopic approach have been stressed.
From May 1995 to January 1997, 237 laparoscopic extraperitoneal inguinal hernia repairs were performed in Department of General Surgery of District Hospital in Szczecin. 197 patient had uni- and 20 bilateral inguinal hernia. The mean age of patients was 51 years. The average time of procedure and hospitalization was 38 min and 1.7 days respectively. Seven (3.2%) recurrences were observed in postoperative observation. As a conclusion, according to authors' achieved experience, one can say that the laparoscopic extraperitoneal inguinal hernia repair is in benefit both for patient and for surgeon.
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The alpha-oxo ketene dithioacetalic derivatives (2a-e) were obtained by the reaction of 2-acetylpyrazine (1) with CS2 and appropriate mono- or dihalogeno-compound. An action of the primary amines and diamines upon 3,3-di(methylsulphanyl)-1-(2-pyrazinyl)-2-propen-1-one (2a) yielded 3-(alkylamino)-3-(methylsulphanyl)-1-(2-pyrazinyl)-2-propen-1-on e (3a-g), 1-(2-pyrazinyl)-2-tetrahydro-1H-2-imidazolyliden-1-ethanone (3h) and the 2-hexahydro-2-pyrimidinyliden-1-(2-pyrazinyl)-1-ethanone derivatives (3i-j), respectively. Tuberculostatic activity of the studied compounds was found to be low except the compound 2b (MIC 192-62 micrograms/cm3; MIC 210-31 micrograms/cm3).