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Biomedical subjects

K Minik

Publications and source records attributed to K Minik.

At least 19 recordsLinked to original sources
PubMed2001

Repeated biopsies in evaluation of therapeutic effects in prostate carcinoma.

BACKGROUND: Apoptosis is one of the major events following total androgen blockade (TAB). The aim of this study was to determine the predictive value of some histological parameters including apoptosis and gene products which influence apoptosis, based on repeated biopsies taken from the same patients. METHODS: At the time of diagnosis by needle biopsy TNM stage, serum PSA, Gleason's grade, apoptotic and mitotic index, Ki67, p53, and bcl(2) expression were investigated in 60 prostate carcinoma patients. Antiandrogen therapy supplemented with surgical or chemical castration was administered. Serum PSA-test and needle biopsy were repeated 13-14 weeks after starting the therapy, simultaneously with determination of the apoptotic and mitotic index, Ki67, p53, and bcl(2) expression. RESULTS: Forty-seven patients were alive at the end of the study, 13 patients died. Decrease in mitotic, increase in apoptotic index predicted favourable long-term response to antiandrogen therapy. Lower Ki67 and (mutant) p53 expression in the first and also in the second biopsy pointed to favourable effect of antiandrogen treatment. Since the ratio between Ki67 and apoptotic index strongly decreased in the survivors upon therapy, changes in Ki67/apoptosis ratio is recommended as a histologically detectable predictive factor. bcl(2) expression did not show significant correlation with the outcome of the disease. CONCLUSIONS: Histological evaluation of mitotic and apoptotic index, Ki67, and p53 expression in repeated biopsies contributes to predicting the value of the actual treatment and may be useful to institute alterations in therapy.

Age Factors↗
PubMed2001

[Precocious puberty caused by a testicular Leydig cell tumor].

Testicular tumors are very rare in boys, approximately 1.5% of these are Leydig cell tumors. The authors present a 4.5 year-old boy with Leydig cell tumor of left testis, which was associated with increased sex steroid production that caused precocious puberty. These tumors are benign processes in prepubertal children. Beyond the rarity of this case the authors would like to report about its diagnostic difficulties and testis-sparing remove of it. The plasma 17-hydroxyprogesterone levels provide the distinction between congenital adrenal hyperplasia and Leydig cell tumor in patient with precocious puberty.

Adrenal Hyperplasia, Congenital↗
PubMed2000

New human Dirofilarioses in Hungary.

About ten cases of filariosis have recently been recorded in the Hungarian medical literature, six of them caused by Dirofilaria repens. Dirofilaria repensis a mosquito-transmitted filaroid worm in the subcutaneous tissue of dogs and cats in the temperate areas of the Old World. It accidentally infects man, too, and can remain unidentified due to physicians, poor knowledge of the parasite. In the last two years six new Dirofilaria repensinfections have been found in various parts of the country: five localised dermally and one in the deep tissues. Two of the cases might have been acquired in Italy during summer travels. Four patients, however, have never been abroad, these cases must be considered autochtonous infections. The thickness of the multilayered cuticle of the worm, diameter of the body and the size, form and number of the longitudinal ridges on its surface are used in the histological diagnosis of the the parasite.

Adult↗
PubMed1997

[Complex screening of family members at risk for familial adenomatous polyposis].

151 members of 10 affected families with FAP have been registered at the authors' regional polyposis registry, among them 51 FAP patients were verified histologically. The disorder is autosomal dominant thus the chance for the inheritance of the mutated allele is fifty percent in the offspring of an affected patient. Because of the high risk the registration and regular control of family members is recommended. They can be divided into high risk and low risk group based on presymptomatic tests. The examination of retina pigmentepithel was the only possibility for presymptomatic diagnosis earlier. After localization and identification of APC gene responsible for the disease molecular genetic methods have been introduced for presymptomatic diagnosis. The authors performed presymptomatic tests based on ophthalmologic and molecular genetic methods among family members at risk. Ophthalmologic examination was done in 53 while molecular genetic investigation in 54 cases. All the results of endoscopic, ophthalmological and molecular genetic examinations were available in 35 persons, among them 19 FAP have been found. Ophthalmological examination were informative in 33 out 35 cases (unequivocal positive or negative) while results of molecular genetic methods and sigmoidoscopy were correlated in every case. Authors stress the significance of complex screening of affected families with FAP in the prevention of colorectal cancer and extracolonic malignant processes.

Adenomatous Polyposis Coli↗
PubMed1997

Difficulties in early diagnosis and treatment of uncommon breast tumours.

The aim of the current study was to analyse the uncommon histological type tumours, occurred in our department in the last 10 years. In the study period 921 patients were treated for breast malignoma, 47.4% of them in early cancer stage. In the latter group 3 cases were observed with rare histological tumour type: secretory juvenile breast cancer T1N0M0, GI /case I/; primary angiosarcoma T1N0M0, GI /caseII/; planocellular breast cancer T2N0M0, GII /caseIII/. In the case of rare histological type tumours: (1) triplet diagnostic procedures are usually able to result in correct preoperative diagnosis; (2) the adequate treatment has to be determined individually; (3) continuous, long term follow-up is necessary; (4) MRI is an appropriate technique in the detection of recurrences.

Biopsy, Needle↗
PubMed1994

[Primary malignant melanoma of the lung and lower respiratory tract].

After detailed analysis of the international special literature, the authors found--together with their own two patients--only 18 cases, considered primer malignant melanoma of the lower respiratory tract and/or lung. Of the accepted criteria, they dispute the obduction's absolute evidentiary role, because among primer patients there are the most who survives, even a decade. In seven cases tumour was located endobronchially and in one patient in the trachea. It was manifested endobronchially and on the dependent lung-areas, simultaneously in two patients and merely parenchymally, in eight. There was a successful resection in fourteen of 18 cases. Survival was influenced primarily by the operability depending on distension of the tumour. Besides procedures forming opinions, bronchoscopy and histological examinations of bioptatum gained this way play a greater role than usual in determining the tumour's primarity, localisation, operability and type of surgery, respectively. Namely, only operated patients can rely on a long survival.

Adult↗
PubMed1994

[Behavior of adamantinoma of the long bones based on long-term follow up studies].

Authors report on the long time (in average 12 years, range: 5-36 years) follow-up results of 5 cases of adamantinoma, localized on the tibia. In one case recurrence was found very late, 20 and 36 years after the primary wide resection, and resection was repeatedly performed. Because of problems of differential diagnosis in one case the tumor was excised intralesionally (curettage + plasty with cancellous bone). 7 years later the persistence of the process was found only. 1 patient died in consequence of pulmonary metastasis 9 years after the primary operation. Wide resection is suggested both for the removal of the primary tumor and the recurrences, appearing very late. For the reconstruction of the bone autologous fibula is proposed. Adamantinoma is thought to be a low malignity tumor, the outcome of which cannot be predicted from the clinical and histological findings. Considering the late recurrences and metastasis a long range, minimally 10 years, following of the patient is thought to be necessary.

Adult↗
PubMed1987

Bronchial papillomas of various origins.

There were five cases of solitary papillomas and three of chronic infectious papillomatosis induced by a foreign body, one caused by broncholithiasis. The five isolated papillomas had verrucous appearances. The common opinion, that the solitary papilloma is likely to be a pedunculary tumor, seems untrue. Squamous or cylindric epithelium covering the same tumor may vary from region to region. We believe that multiple polyps caused by inhalation of hot, burning, and corrosive gases are of inflammatory origin. Once the causative factor (eg, a late diagnosed foreign body) is removed, the inflammatory papillomatosis may resolve spontaneously. After the removal of a benign papilloma, recurrence is usually caused by lack of operative radicality rather than by malignancy. Laser technique and other coagulation methods make it possible to remove most tumors by performing bronchoscopy with only little risk. Papillomas showing the signs of atypia and peribronchial spreading require later surgery.

Adult↗
PubMed1985

Screening for colorectal cancer in a Hungarian county.

An initial screening for colorectal cancer in asymptomatic adults was performed with Haemoccult in 26,357 persons, rigid rectoscopy in 10,673 and flexible sigmoidoscopy in 3,963 persons. The rate of cancer detection was 4.4% in screenees with a positive Haemoccult test, 0.08% using rigid rectoscopy and 0.28% using flexible sigmoidoscopy. The respective frequency of patients discovered to have polyps was 16.2%, 1.32% and 8.49%. 77% of the 36 colorectal cancers detected due to the Haemoccult test program were either Dukes A or B. A comparison of these screening results indicates that Haemoccult screening markedly increases the yield of colorectal neoplasms when asymptomatic persons are examined. This screening should be repeated annually to reduce the morbidity and mortality of colorectal cancer.

Adenoma↗
PubMed1983

Carcinoid tumours of the rectum.

Carcinoid tumours of the rectum occur relatively seldom. The personal experience was 11/20,0000 rectoscopies. The symptoms are not characteristic. Such tumours can mostly be detected by chance. The basic diagnosis can only be achieved through thorough histological examinations. The tumours are usually not larger than 1 1/2 cm in diameter. Usually are restricted to the mucosa and submucosa, are solitary and can be treated perfectly with endoscopic excision. In case the tumour either invades the muscular layer, reaches or exceeds the diameter of 2 cm, or occurs in a multiple form a radical surgical approache is needed, resection should be performed.

Adult↗
PubMed1982

Colitis carcinoma in ulcerative colitis.

During the period from 1963 till 1981 altogether 342 patients suffering from ulcerative colitis were treated. In their material authors found 6 patients (1.7%) who achieved cancer of the colon beginning 7, 9, 14, 18, 18 und 21 years after the onset of ulcerative colitis symptoms. According to the clinical data their ulcerative colitis could be considered to belong to the severe or the moderate type. From the anatomical point of view the extension of the process exceeded the sigmoid colon in all but one. Respecting the clinical course of the disease, malignant transformation took place in 3 patients of the relapsing-remitting type, in 2 instances the clinical course could not be classified, the sixth case proved to the chronic continuous type. Colonic tissue was gained and diagnosis stated with traditional methods within 4 instances, while in 2 it was gained from tissue specimens passing through the stool. In 3 cases the tumour was multiple. From the morphological point of view the features had a plaque form in 2 cases, a polypous nature in other 2 cases, while among each one patient a fibrous stricture and ordinary colorectal cancer occurred. The tumour was identified as well differentiated and poorly differentiated adenocarcinoma in identically 3 instances. All the patients underwent an operation, only one of them is still alive. In sake of detecting colitis carcinoma earlier, they suggest yearly endoscopic and biopsy survey of ulcerative colitis patients.

Adult↗