K Miskolczi | PubMed Health

PubMed1992

[Experience with hydrogen (H2) breath test].

The authors applied regularly the hydrogen (H2) breath test during the medical investigations in patients with gastrointestinal symptoms. On the basis of the repeated examinations the hydrogen (H2) breath test is a sensitive, well repeatable method. After analysing of 108 examinations the authors have observed in 51.8% lactose intolerance, in 17.8% small intestinal bacterial overgrowth syndrome, in 46.4% motility disorders. The proportion of "low hydrogen producers" was 14.3%. Only 1/5 of patients with new diagnosed lactose intolerance had knowledge about the intolerance, and 10% was asymptomatic. In case of small intestinal bacterial overgrowth syndrome the repeated hydrogen (H2) test may indicate the effectivity of applied antibiotic therapy. The mean orocaecal transit time was 99 minutes and the normal range was 66-132 minutes, counted on the basis of mean +/- 2 SD. The authors suggest that the results support the important role of hydrogen (H2) breath test in the modern gastroenterological diagnostics.

Breath Tests↗

PubMed1989

Short term treatment of type II hyperlipoproteinaemia with silymarin.

In a seven-month open clinical study on 14 type-II hyperlipidaemic outpatients, the effects of silymarin (Legalon), an antioxidant and hepatoprotective agent, were investigated. Blood lipid, lipoprotein and apolipoprotein concentrations, as well as liver and renal function parameters were measured. After determining baseline values, patients were treated with 420 mg Legalon daily for three months. After a two-month placebo period, the treatment was repeated with Legalon for a further month. In respect to the serum lipid and lipoprotein concentrations, there were no remarkable changes except that the total cholesterol and HDL-cholesterol levels slightly decreased. At the 12th week, in all cases, the apolipoprotein levels were somewhat decreased compared to the baseline values. By the significant decrease of both apo A-I and A-II values, a decrease of the total structural protein amount of HDL, and thus a relative increase in the proportion of cholesterol in HDL fraction was suggested. There were minor changes in serum protein concentration and liver function tests, but all values remained within the normal range. All of the renal function parameters remained unchanged during both treatments and the placebo periods. An additive role of Legalon in the therapy of secondary hyperlipoproteinaemia resulting from different liver diseases is discussed.

Cholesterol↗