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Biomedical subjects

K Moles

Publications and source records attributed to K Moles.

5 recordsLinked to original sources
PubMed1992

Marked improvement in parameters of renal osteodystrophy with the use of intraperitoneal calcitriol.

Parenteral administration of Calcitriol is felt to be superior to oral Calcitriol in the treatment of renal osteodystrophy in chronic renal failure patients. We analyzed the results of serum calcium, phosphorus, alkaline phosphatase, and N-terminal parathormone level which are the clinical parameters of renal osteodystrophy in twenty-three chronic peritoneal dialysis patients who received varying dosages of intraperitoneal Calcitriol. The results which were analyzed at the end of one to twenty-three months revealed significant increase in serum calcium and a significant decrease in the values of alkaline phosphatase and N-terminal parathormone level.

Alkaline Phosphatase↗
PubMed1990

Feasibility of in-center staff-assisted cycler dialysis.

Many debilitated elderly patients are not currently considered for peritoneal dialysis because they cannot perform the procedure themselves and they lack adequate back-up support in the family or extended care facility. They often tolerate hemodialysis poorly, and may exhaust their vascular access sites. We have provided intermittent in-center staff-assisted cycler dialysis to two debilitated elderly patients for a total of 12 patient months. Initial peritoneal equilibration tests indicated high solute transport rates in both patients, and led us to evolve a regimen based on frequent cycles. We use a 4 days a week regimen, cycling 12-14 liters during a 7.5 hour period each day. The patients tolerated the treatment well, with improved control of fluid balance and maintenance or improvement in appetite compared to baseline periods of CAPD. Mean pre-treatment BUN is 87 mg/dl. This is 29% higher than during CAPD, and has been stable. The requirement for additional nursing care has been variable but not disruptive of other activities once we established a dedicated space and routine. Current cycler technology permits consideration of in-center cycling as a practical alternative for many patients previously excluded from peritoneal dialysis.

Aged↗
PubMed1989

Cycler dialysis evolution.

Use of automated cycler equipment is currently limited to a fraction of the peritoneal dialysis population. Various technical barriers combined in the past to inhibit its wider application. We have treated forty-seven patients over an eight year period with cycler dialysis, and have observed the evolution of this modality from a treatment of last resort to a first choice therapy for many patients--especially those who work.

Hemodialysis, Home↗
PubMed1986

Comparison of transdermal nitrate and isosorbide dinitrate in chronic stable angina.

The effects of transdermal nitrate (TN) (Transiderm-Nitro TTS, Geigy Pharmaceuticals, one 10 cm2 patch daily) and oral isosorbide dinitrate (ISDN) (Sorbitrate, Stuart Pharmaceuticals, 10 mg three times daily) were compared in a group of 20 patients with chronic stable angina pectoris. Treadmill exercise duration was prolonged from a median time of 365 s to 428 s after ISDN (P less than 0.05), but was unchanged after TN. The difference between the active treatments was not significant. Weekly consumption of glyceryl trinitrate (GTN) increased during treatment with TN from a median value of 5.5 to 6.3 (P less than 0.05). A decrease was observed after ISDN (7.8 to 3.9, P = NS), and the difference between the drugs was significant (P less than 0.01). Systolic arterial pressure was significantly lower during the ISDN than during the TN treatment period in both the supine (135 +/- 5 vs 128 +/- 5 mm Hg; P less than 0.05) and standing positions (134 +/- 5 vs 122 +/- 5 mm Hg; P less than 0.05). No change in weekly attack rate, the degree of ST depression at angina on treadmill testing, or the number of episodes of ST depression recorded during a 24 h period by Holter monitoring was observed after either drug. In this study, an antianginal effect was demonstrated for ISDN but not for TN. It is suggested that the dose of TN may have been inadequate to demonstrate such an effect, and further studies using a higher dose schedule will be required.

Administration, Oral↗