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K Moridera

Publications and source records attributed to K Moridera.

34 records · Page 2Linked to original sources
PubMed1991

[A case of pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis].

We report a patient with pregnancy-induced lymphocytic adenohypophysitis complicated by postpartum painless thyroiditis. A 27-year-old female noticed visual field defect in the 36th week of pregnancy. After delivery in the 39th week by cesarean section, she was admitted for close examination. Goiter was not palpable, and postpartum galactorrhea was not observed. Routine examination revealed no abnormal findings. On October 8, 1989, magnetic resonance imaging (MRI) revealed a tumor image (height 22.4mm) from the sella turcia to suprasellar cistern with a lower signal intensity than that of the white matter on T1 weighted images and a high signal intensity on T2 weighted images. Gd-DTPA contrast images showed a symmetrical and homogeneous tumor image at the same site. However, the posterior lobe of the pituitary gland appeared normal. These findings suggested lymphocytic adenohypophysitis. The LH was less than 0.3mIU/ml. The FSH (7.8mIU/ml), PRL (12ng/ml), GH (1.6ng/ml) and cortisol (10 micrograms/dl) levels were normal. T4 was 5.3 micrograms/dl, T3 67ng/dl, fT4 0.53ng/dl, which indicated mild hypothyroidism, but the TSH was normal. TRH test showed a slight increase in TSH and no response of PRL. Insulin tolerance test showed delayed response of GH and normal response of cortisol. LHRH test revealed no response of LH and delayed response of FSH. Anti-GH3 cell antibody and anti-thyroglobulin antibody were positive, but the anti-AtT20 cell antibody was negative. Since visual disturbance improved, and slight reduction in the mass (height 20.1mm) was confirmed by MRI after delivery on October 21, her course was observed without treatment. After 1 month, the LH became detectable, but the PRL and cortisol decreased to 2.5ng/ml and 6.0 micrograms/dl, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1991

Effects of sex and age on serum GH binding protein levels in normal adults.

OBJECTIVE: The effects of sex and age on serum growth hormone binding protein (GHBP) levels during adulthood were investigated. DESIGN: The levels of GHBP, insulin-like growth factor-I (IGF-I), and growth hormone (GH) were determined and analysed as a function of sex and age. PATIENTS: We studied 101 normal adults (45 men, aged 20-77 years; 56 women, aged 20-80 years). MEASUREMENTS: GHBP levels were determined using an Ultrogel AcA 44 minicolumn. RESULTS: During the second and third decade, GHBP levels were not different between men (22.8 +/- 1.1%) (mean +/- SE) and women (23.2 +/- 0.8%). After the age of 40 years, however, GHBP levels in men were significantly decreased (19.1 +/- 0.7%), and were lower than those in women (22.7 +/- 0.9%). IGF-I levels correlated positively with GHBP levels in men (r = 0.51, P less than 0.01) but not in women (r = 0.16, NS). CONCLUSIONS: These results indicate that both sex and age may have some effects on the GH-GH receptor-IGF-I axis.

Adult↗
PubMed1991

LH- and FSH-secreting pituitary adenoma in a postmenopausal woman.

Gonadotropin secreting pituitary adenomas have been reported with increasing frequency in men, but they are still rarely recognized in women. We report a 52-year-old postmenopausal woman with LH- and FSH-secreting pituitary adenoma. She had increased LH (37.0 +/- 13.7 IU/l) (mean +/- SD) and FSH (109.9 +/- 26.7 IU/l) but these concentrations were within normal ranges in 80 postmenopausal women (LH: 29.7 +/- 18.3 IU/l, FSH: 104.0 +/- 43.9 IU/l). The administration of GnRH and conjugated estrogen resulted in normal response of LH and FSH. No abnormal response of gonadotropin to TRH and bromocriptine was observed. After transsphenoidal adenomectomy both LH and FSH decreased (LH: 11.1 +/- 4.2 IU/l, FSH: 37.0 +/- 9.6 IU/l). An immunocytochemical study revealed that the adenoma cells synthesize both LH and FSH. The rarity of gonadotropin secreting pituitary adenomas in women could be the result of greater difficulty in recognition due to an increase in serum gonadotropin in postmenopausal women.

Adenoma↗
PubMed1986

The polymorphism linked to the human insulin gene: its lack of association with either IDDM or NIDDM in Japanese.

Polymorphism of 5' portion of the human insulin gene was examined in 188 unrelated Japanese subjects (49 normal, 71 with IDDM, and 68 with NIDDM) using restriction endonuclease analysis. Restriction fragments were classified according to the insertion size: Class 1 (600 base pairs), Class 2 (1300 base pairs), and Class 3 (2000 base pairs). We found a very high frequency of Class 1 alleles (96.8%) and a low frequency of both Class 2 (0.8%) and Class 3 alleles (2.4%) and that approximately 94% of the genotypes were Class 1/Class 1 homozygote. In addition, there was no correlation of allelic or genotypic frequency with NIDDM or IDDM. We conclude that length polymorphism of the human insulin gene cannot be a useful marker for diabetes in Japanese.

Diabetes Mellitus, Type 1↗
PubMed1983

The prevalence of diabetic autonomic neuropathy indicated by abnormal R-R interval variation.

The variation in R-R interval in ECG has been reported to decrease in diabetics with autonomic neuropathy. To investigate the diagnostic value of heart rate monitoring and the prevalence of diabetic autonomic neuropathy, R-R interval variations (CVs) were measured, and the relationships between CV and MCV, FCV, SCV, retinopathy, nephropathy, peripheral neuropathy, and duration of diabetes were investigated. 70 diabetics aged 19 approximately 74 were studied. A total of 100 consecutive R-R intervals on ECG were analyzed by computer. 16 patients (22.8%) of 70 had one or more symptoms of autonomic neuropathy, while the prevalence of diabetic autonomic neuropathy indicated by abnormally low CV was 41.4%. Diabetics with retinopathy, nephropathy or peripheral neuropathy had significantly lower CVs than diabetics without these complications (p less than 0.01). The correlation coefficients for CV and duration of diabetes, and CV and SCV were -0.69 and 0.57 respectively (p less than 0.01). CV (%) of R-R interval was a useful parameter for the determination of diabetic autonomic neuropathy and our results showed that autonomic nerve damage was more prevalent than were symptoms of autonomic neuropathy.

Adult↗
PubMed1975

Restoration of normal pituitary gonadotropin reserve by administration of luteinizing-hormone-releasing hormone in patients with hypogonadotropic hypogonadism.

To elucidate whether diminished pituitary gonadotropin reserve can be restored by repeated stimulation with luteinizing-hormone-releasing hormone, plasma luteinizing hormone and follicly-stimulating hormone responses were studied before and after daily intravenous infusion of 400 mug of luteinizing-hormone-releasing hormone for two to 23 days, in patients with hypogonadotropic hypogonadism of various causes. In five of nine patients with isolated gonadotropin deficiency, the impaired plasma luteinizing hormone response was restored to normal after treatment for seven days or more, whereas it was unchanged in four patients treated for less than five days. However, six patients with anorexia nervosa regained normal responses after three to five days' treatment. Five of nine patients with organic hypothalamopituitary lesions also showed normal responsiveness after five to seven days' treatment. These results suggest that the response to the test after repeated administration of luteinizing-hormone-releasing hormone is of value for the diagnosis of hypogonadism of hypothalamic origin.

Adolescent↗
PubMedDate not supplied

Is growth hormone associated with diabetic retinopathy?

The role of growth hormone (GH) in the pathogenesis of diabetic retinopathy was evaluated in 150 patients with non-insulin-dependent diabetes mellitus by measuring urinary GH excretion using a highly sensitive enzyme immunoassay. Urinary GH excretion was not significantly different among diabetic patients without retinopathy (mean, 2.4 ng/day; range, < 0.3-20.0 ng/day), with background retinopathy (2.7 ng/day; < 0.3-22.0 ng/day), and with proliferative retinopathy (3.1 ng/day, 0.9-15.6 ng/day). These data suggest that GH does not play a role for the pathogenesis of diabetic retinopathy through the increased physiological secretion.

Adult↗
PubMedDate not supplied

Ectopic prolactinoma on MRI.

OBJECTIVE: We present two patients with ectopic prolactinoma in the sphenoid sinus who were examined by MRI. MATERIALS AND METHODS: Endocrinological evaluations including spontaneous and drug-induced secretion of prolactin (PRL) and MRI features of two patients with ectopic prolactinoma were studied. RESULTS: Both patients had elevated serum PRL levels, and the endocrinological evaluations were similar to those in ectopic prolactinoma. Magnetic resonance of the head revealed a mass occupying the sphenoid sinus with partially empty sella in Case 1 and with normal pituitary gland in Case 2. Ectopic PRL secretion was confirmed by immunocytochemical examination of the ectopic tumor. Case 1 was treated with bromocriptine, leading to marked decrease in serum PRL levels and reduction of tumor size. Transsphenoidal surgery was performed in Case 2, resulting in normalization of serum PRL levels. CONCLUSION: It is necessary to consider ectopic prolactinoma for the differential diagnosis of the sphenoid sinus tumors.

Adult↗