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Biomedical subjects

K Morooka

Publications and source records attributed to K Morooka.

31 records · Page 2Linked to original sources
PubMed1978

A study on simultaneous symmetrical motions.

Three right handed male subjects performed a simultaneous symmetical task involving the motions of reach and pressing buttons. Simultaneous performance time was investigated at several symmetical locations. The symmetrical locations were defined by the combinations of different levels of separation distance, angle and distance. Three levels of separation distance (3, 9 and 15 inches), seven levels of angle (0, 15, 30, 45, 60, 75 and 90 degrees from the frontal reference plane) and three levels of distance (6.5, 11.0 and 15.5 inches) were applied to both hands equally. It was found that separation distance, angle and distance were significant factors in simultaneous performance. The performance time was increased when the symmetrical angle region was varied from the 0--45 degrees region to the 45--90 degrees region. Specifically, the performance time was at the minimum at 15 degrees of symmetrical angle and at the maximum at 90 degrees of symmetrical angle. In addition, the performance time increased not only as the distance of the moves was increased, but also as the separation distance interval was increased (i.e., the separation distance interval varied from a 3--9 inch interval to a 9--15 inch interval).

Functional Laterality↗
PubMedDate not supplied

Clinical effects of allopurinol on intractable epilepsy.

We studied the clinical efficacy of allopurinol as add-on therapy in 31 patients with intractable epilepsy. When administered for a short time, allopurinol was effective in 17 patients (55%); 8 were seizure-free, 8 had 75% decrease in seizure frequency, and 1 had greater than 50% decrease. Allopurinol was most effective in patients with localization-related epilepsy, especially in secondarily generalized tonic-clonic seizures. Allopurinol was not as effective in patients with Lennox syndrome or West syndrome, or in severe myoclonic epilepsy in infants. When allopurinol was administered greater than 1 year, its initial effectiveness continued in 8 of 14 patients who exhibited initial improvement. In 2 of the remaining 6 patients, the initial improvement disappeared during the course of treatment but control was regained by increasing the dosage of allopurinol. Mild side effects were observed in 4 patients (13%): drowsiness in 3 and abdominal pain in 1. Allopurinol may be a useful antiepileptic drug (AED), and a double-blind placebo-controlled trial should be performed.

Adolescent↗
PubMedDate not supplied

Fine needle aspiration cytology of clear cell sarcoma. Report of a case with immunocytochemical, immunohistochemical and ultrastructural studies.

Cytologic findings of clear cell sarcoma obtained by fine needle aspiration (FNA) of a tumor are described. The tumor probably originated in the retroperitoneal tissue, and the diagnosis was confirmed histologically by open biopsy. Percutaneous needle aspirates of the intraabdominal tumor and touch preparations obtained from the open biopsy specimen revealed numerous atypical cells with an extremely hyperchromatic nucleus, prominent nucleoli and clear cytoplasm. The cytoplasm was rich in glycogen. The immunocytochemical technique demonstrated S-100 protein and neuron-specific enolase in the cytoplasm, both of which were exhibited also in the histologic specimen. Clear cell sarcoma is a rare tumor of soft tissue, and to our knowledge, detailed cytologic appearances of this tumor obtained by FNA have not been reported. In addition, the present tumor was unique in location. It is possible to diagnose clear cell sarcoma accurately on an FNA cytologic specimen if the periodic acid-Schiff stain and immunocytochemical technique are utilized in addition to the routine Papanicolaou method.

Biopsy, Needle↗