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K Morozumi

Publications and source records attributed to K Morozumi.

At least 73 records · Page 4Linked to original sources
PubMed1996

[MPO-ANCA positive two cases associated with interstitial pneumonitis].

We describe two cases (61-year-old female and 71-year-old male) with MPO-ANCA (myeloperoxidase-antineutrophil cytoplasmic antibody) positive who developed severe interstitial pneumonitis. They presented at our hospital with dyspnea and dry cough. The hypoxia and abnormal shadow on chest X-ray led to a diagnosis of interstitial pneumonitis. Serologic studies revealed the high titers of MPO-ANCA in two cases. They were treated with methylprednisolone, immunosuppressant agents and plasma exchange. The pneumonitis and the titers of MPO-ANCA improved on these therapies, The former was introduced continuous hemodialysis therapy and the later continued nephrotic syndrome. These renal damages did not recover, regardless of the reduction of the titers of MPO-ANCA. It is concluded that methylprednisolone pulse therapy, immunosuppressant agents and plasma exchange therapy are useful to interstitial pneumonitis in patient with positive of MPO-ANCA. The measurement of MPO-ANCA is useful to interstitial pneumonitis in patient with positive of MPO-ANCA. The measurement of MPO-ANCA is useful maker of interstitial pneumonitis for unknown causes.

Aged↗
PubMed1995

[Tubulo-interstitial lesions in human renal allograft].

Tubulo-interstitial lesions developed in renal allografts are divided to two major categories, i.e., primary group specific for renal allografts consisting of rejection, cyclosporine nephrotoxicity and post-transplant acute tubular necrosis, and secondary group accompanied with nephron atrophy caused by any kinds of glomerular, interstitial and/or vascular diseases. An international classification for renal allograft biopsy called Banff criteria was proposed and a comparative study using this criteria would be possible in any place of the world hereafter. After a clinical application of potent immunosuppressive agent cyclosporine or taclorimus, acute and chronic rejection related tubulo-interstitial lesions changed to mild and less specific findings for rejection required a new specific diagnostic criteria for chronic rejection. A concomitant lesion with rejection, glomerulonephritis and cyclosporine nephrotoxicity was an ordinary diagnosis in cyclosporine era. New diagnostic methods using immunohistochemistry and electron-microscopy will contribute to a new and sophisticated pathologic classification for tubulo-interstitial lesions of renal allografts.

Cyclosporine↗
PubMed1994

Fabry-like laminated myelin body associated with IgA nephropathy.

We present the first female patient to exhibit Fabry-like myelin bodies in the glomerular epithelial cell in association with IgA nephropathy. This previously healthy 36-year-old woman presented with proteinuria and hematuria without skin lesions. Renal biopsy showed typical IgA nephropathy, with paramesangial deposits, mesangial proliferation and scattered myelin bodies. The leukocytic alpha-galactosidase A activity was abnormally low. She had no family history of Fabry's disease nor the characteristic features, such as skin lesion, neuralgia, or hypohidrosis. Fabry's disease is diagnosed from the renal biopsy findings and the activity of alpha-galactosidase A in leukocytes and/or fibroblasts. We diagnosed the present case with Fabry' disease and IgA nephropathy from these results.

Adult↗
PubMed1994

Renal complications during pregnancy in a patient with diabetes mellitus.

We present a 23-year-old woman with a 7-year history of insulin-dependent diabetes mellitus (IDDM) who became pregnant. At the 23rd week of pregnancy she exhibited the signs and symptoms (hypertension, edema, proteinuria) of both diabetic nephropathy and preeclampsia. A cesarean section was successfully performed. The proteinuria persisted for more than 3 months after delivery. Renal biopsy confirmed the diagnosis of diabetic glomerulosclerosis together with the renal findings attributable to preeclampsia. The rapid acceleration of diabetic nephropathy in this patient was attributed to preeclampsia. We therefore recommend that patients with DM be followed closely during pregnancy in an attempt to prevent the acceleration of renal damage by preeclampsia.

Adult↗
PubMed1994

[Nephropathy in patients with mixed connective tissue disease].

The first report of mixed connective tissue disease (MCTD) was described that nephropathy was rare complication of the patients with MCTD. Recently, some authors reported that the nephropathy was 25-50% of patients with MCTD. This report investigated the histopathological findings of patients with MCTD. This study was conducted on 17 patients associated with MCTD. In clinical features, there were six of nephrotic syndrome and two of hematuria and proteinuria. They were normal renal function, expect for one case (case MF). In pathological findings, there were four of membranous nephropathy, two of mesangial proliferative glomerulonephritis, including one of IgA nephropathy, and 11 of minor glomerular abnormality. Three cases translated to systemic lupus erythematosus (SLE) during follow-up period (1 to 5 years). They had hypocomplementemia and membranous nephropathy in common. In conclusion, the nephropathy is not rare complication in patients with MCTD. Sex of the 17 patients (35.3%) with MCTD have nephropathy. MCTD cases with immune-complex glomerulonephritis are likely to transit from MCTD to SLE.

Adolescent↗
PubMed1994

[Nephropathy in patients with primary antiphospholipid antibody syndrome].

Primary antiphospholipid antibody syndrome (APS) is characterized by abortion, thrombosis, thrombocytopenia and/or valvular disease and it is liable to complicate systemic lupus erythematosus (SLE). We carried out a study to investigate the clinical and renal pathological findings in five patients with APS, but not SLE. In the clinical findings, the patients had negative tests for proteinuria and hematuria, and their renal function and tubular function were within normal limits. In the light microscopic findings, three patients exhibited mild mesangial hypercellularity, and two had minor glomerular abnormalities. In immunofluorescent study, there were IgM and/or C3 depositions in the mesangial area in some cases, and in electron microscopic study, there were no special findings other than mesangial hypercellularity. In conclusion, nephropathy is a rare complication in patients with APS, unlike systemic lupus erythematosus.

Adult↗
PubMed1993

The effect of enalapril on proteinuria in patients with chronic glomerulonephritis and renal insufficiency.

We evaluated the effect of enalapril on proteinuria in 20 patients with chronic glomerulonephritis (CGN) and renal insufficiency. Patients were accepted into the study according to the following criteria: 1) a serum creatinine (s-Cr) level over 1.5 mg/dl or a creatinine clearance (Ccr) under 70 ml/min; and 2) urinary protein (UP) over 1.0 g/day, expect for the cases with uncontrollable hypertension. We measured total protein (TP), albumin, s-Cr, Ccr, UP, and Ht during the elanapril therapy. After enalapril therapy, UP slowly decreased, and TP and albumin levels increased. The levels of s-Cr and Ccr did not vary. None of the patients required discontinuation of enalapril therapy caused by side effects, such as anemia or hyperkalemia. In conclusion, enalapril has the effect of decreasing in proteinuria and increasing TP and albumin in patients with CGN and renal insufficiency irrespective of the original diseases.

Adolescent↗