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Biomedical subjects

K N Kazeev

Publications and source records attributed to K N Kazeev.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Adenylate cyclase activity and cyclic nucleotide content in human adrenal tumors under Icenko-Cushing syndrome].

The adenylate cyclase activity and cyclic nucleotide content in excised human adrenal tumours (Icenko-Cushing syndrome) were determined. The experimental data were compared to those obtained for hyperplastic adrenals. All adrenal tumours under study revealed a decreased cAMP level, an increased cGMP level and a resulting decrease of the cAMP/cGMP ratio. In malignant adrenal tumours the adenylate cyclase activity was sharply increased in comparison with that in hyperplastic adrenals. In the majority of malignant tumours the adenylate cyclase response to ACTH was either altogether absent or sharply decreased. In benign adrenal tumours the basal activity of the enzyme was unchanged and the enzyme response to ACTH was essentially normal. The decrease of adenylate cyclase response to ACTH in malignant tumours is apparently not due to the impaired catalytic activity of the enzyme, since its response to stimulation by sodium fluoride remains unaffected. In some tumours (one malignant and two benign ones) a non-specific stimulation of adenylate cyclase by hormones, which are not natural activators of the enzyme was observed. It was assumed that these changes are due to the damage of hormonal receptors in adrenal tumours.

Adenylyl Cyclases↗
PubMed1980

[Surgical treatment of different forms of hyperaldosteronism with low renin activity in the blood plasma].

The clinical picture and biochemical values in patients with arterial hypertension and concomitant hyperaldosteronism and low renin activity in blood plasma due to adenoma of the adrenocortical glomerular zone and in its absence were studied before and after surgical treatment. An attempt is made to substantiate the expediency of surgical or nonoperative treatment of patients with aldosteroma or bilateral hyperplastic process in the adrenals.

Adrenal Cortex Neoplasms↗
PubMed1980

[Indirect lymphography in the preoperative diagnosis of thyroid and parathyroid diseases].

The authors come to a conclusion that indirect lymphography is an effective method for the diagnosis of alterations in the thyroid gland (thyroiditis, malignant tumor, diffuse and nodular goiter). It can be also used in order to establish the state of its regional lymph nodes more exactly. The thyroid gland lymphography added by contrasting the esophagus is a simple and effective method for topical preoperative diagnosis and determination of localization of the altered parathyroid gland.

Adolescent↗