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K N Kazeev

Publications and source records attributed to K N Kazeev.

70 records · Page 4Linked to original sources
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[Dynamics of clinico-immunologic indices in patients with endocrine ophthalmopathy undergoing treatment with the preparation parlodel].

The immune status and the time course of ophthalmological indices were studied in 54 patients with endocrine ophthalmopathy during bromocriptine therapy. Twelve weeks after the onset of therapy indices of the immune status returned to normal in parallel with the regression of ophthalmological symptoms. In the control group (20 patients with endocrine ophthalmopathy who did not receive bromocriptine) significant improvement of the clinicoimmunological status was unnoticed. An increase in the number of T-lymphocytes, a decrease in the number of B-lymphocytes, an increase in the level of IgG, and a decrease in the levels of IgA and IgM were observed during bromocriptine therapy. The time of the immunity indices could serve as a criterion of bromocriptine therapeutic efficacy in patients with endocrine ophthalmopathy.

Adult↗
PubMedDate not supplied

[Immediate results of parlodel treatment of patients with diffuse toxic goiter complicated by endocrine ophthalmopathy].

The authors reported the results of parlodel therapy of 18 patients with diffuse toxic goiter complicated by endocrine ophthalmopathy. The patients ranged in age from 24 to 59 with a period of disease from 3 months to 10 years and more. The drug was given for 6 weeks at a dose of 2.5 mg twice a day after meals, a course dose varied from 150 to 225 mg. A radioimmunoassay was used to determine T3, T4 and TTH, the patients underwent a thorough ophthalmological examination. Six weeks after parlodel therapy was initiated, a decrease in the TTH level up to normal values was observed in parallel with the regression of clinical signs of endocrine ophthalmopathy. The use of parlodel did not change considerably the level of the thyroid hormones T3 and T4.

Adult↗
PubMedDate not supplied

[Adenylate and guanylate cylase system function in human hyperplastic adrenals in Itsenko-Cushing disease].

The content of cyclic nucleotides and the activity of adenylate and guanylate cyclases as well as of cAMP phosphodiesterase in the human hyperplastic adrenals were determined after one- and two-step bilateral adrenalectomy for Itsenko-Cushing's disease. A decrease in cGMP concentration and a corresponding increase in cAMP/cGMP correlation were seen in the 2nd hyperplastic adrenal comparatively to those in the 1st one. An enhanced basal activity of adenylate cyclase and its lowered sensitivity to ACTH were found in the 1st and the 2nd adrenals. These changes correlate with a rise in the blood ACTH concentration in patients after the ablation of one adrenal. It is suggested that the augmented adenylate cyclase activity leads to an increased activation of steroidogenesis enzymes in the rest adrenal, ensuring the elevated rate of corticosteroid secretion. The nature of changes in guanylate cyclase activity is contrary to that of adenylate cyclase; namely, guanylate cyclase basal activity of the 2nd hyperplastic adrenal was shown to be lower than that of the 1st one. The cAMP phosphodiesterase activity in the 1st and the 2nd adrenals remained unchanged.

3',5'-Cyclic-AMP Phosphodiesterases↗
PubMedDate not supplied

[Thyroliberin test in the diagnosis of thyroid cancer].

The function of the hypothalamus-pituitary-thyroid system was studied in patients with nodular diseases of the thyroid gland to determine the importance of the thyroliberin test for the diagnosis of thyroid cancer. Patients with thyroid cancer develop profound disturbances in the hypothalamus-pituitary-thyroid system. Unlike benign nodular thyroid diseases, the cancerous process is marked by suppression of the pituitary responsiveness to stimulation with thyroliberin while the degree of thyrotropin level elevation turns out twice as decreased after thyroliberin administration. The thyroliberin test can be used in differential diagnosis of malignant and benign nodular diseases of the thyroid gland. The sensitivity of cancer as regards "the lowered thyrotropin index" calculated as the ratio of stimulated thyrotropin to basal one constitutes 85%, specificity 89.5%.

Adenoma↗
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[Familial forms of chromaffinomas].

The familial chromaffinoma forms were seen in 13 members of 4 families. Eight of these patients (6 females and 2 males), aged 15 to 43 years old, were operated for disseminated bilateral chromaffinomas. Seven patients had malignant tumors. In 3 families there were patients with Sipple's syndrome. Extensive laparatomy is rather preferential by surgeons. In view of the autosomal-dominant form of the disease transmission it is necessary to investigate thoroughly the familial history and to examine purposefully the children and relatives of patients with chromaffinomas, especially, with Sipple's syndrome.

Adolescent↗
PubMedDate not supplied

[New possibilities of topical x-ray diagnosis of hyperparathyroidism].

The authors analyze materials of topic X-ray diagnosis of the parathyroid glands in 12 patients with hyperparathyroidism and in two patients in whom this disease was suspected. They consider that indirect lymphography of the thyroid gland combined with the esophagus contrasting is a simple and effective method for detecting the localization of the parathyroid gland lesions. In interpreting the roentgenogram one should take into consideration the changes in the thyroid gland capable of simulating the pathological process in the parathyroid glands. Marked deformity of the skeleton serves as a relative contraindication to topic X-ray diagnosis of the parathyroid glands.

Adolescent↗
PubMedDate not supplied

[Dynamics of changes in the indicators of electrolyte metabolism after surgical treatment of Cushing's syndrome].

The authors present the results of study of the state of the water-electrolyte metabolism at the early postoperative period in 58 patients suffering from Itsenko-Cushing's disease with consideration of the potassium deficiency correction. Potassium and sodium level was studied in the plasma and the erythrocytes. Besides, in 31 patients potassium and sodium content were examined in the muscular tissue obtained during the operation. Hypoglycemia was revealed in 48.2% of the cases, and hypernatriemia--in 19.0%. A reduction of potassium level in the erythrocytes was revealed in 50%, and a rise of sodium--in 52% of cases. The muscle tissue potassium level fell in parallel to the reduction of this electrolyte level in the erythrocytes. Disturbances of the electrolyte balance proved to be most pronounced at the early postoperative period in the patients given no potassium preparations. Separate use of potassium preparations, or (particularly) together with veroshpiron, prevented potassium deficiency at the early postoperative period.

Adolescent↗
PubMedDate not supplied

[Dynamics of EKG changes in patients with Itsenko-Cushing disease before surgery, and following the 1st and 2d stages of adrenalectomy].

The results of examination of ECG in 44 patients suffering from Itsenko-Cushing's disease at different stages of surgical treatment are presented. The data obtained were compared with the blood potassium and sodium levels, 17-KS, and 17-OCS levels in the urine, arterial pressure and cholesterol content. Various ECG changes before the operation were revealed in 39 patients. Signs of enlargement of the left ventricle and deformity of the end part of the ventricular complex (negative T wave and or reduction of S-T segment in I, II, avL V5-6 leads) were found in 8 patients, and deformity of the end part of the ventricular complex without any signs of enlargement of the left ventricle--in 18 patients. There proved to be a significant dependence of the changes in the end port of the ventricular complex on increased urinary excretion of 17-OCS, hypokaliemia and hypernatriemia. Negative ECG changes after bilateral total adrenalectomy was significantly connected with postoperative hypocorticism.

17-Hydroxycorticosteroids↗
PubMedDate not supplied

[Lymphography of the thyroid gland. 1].

The authors carried out a lymphographic examination in 11 patients with various diseases of the thyroid gland. Lymphography proved to be an effective and harmless diagnostic method in pathological changes of the thyroid gland. Different structure of the thyroid gland tissue was revealed on the lymphograms depending on the character of the pathological process. In establishment of the diagnosis one should take into consideration the structure of the thyroid gland tissue, the structure of the cervical lymph nodes, and possibilities of their filling with the contrast agent, the amount, the rate and difficulties encountered in the administration of the contrast substance.

Adolescent↗