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Biomedical subjects

K N Udupa

Publications and source records attributed to K N Udupa.

At least 19 recordsLinked to original sources
PubMed1992

Biogenic amines and thyrotoxicosis.

Circulating levels of T3, T4, gamma-amino-butyric acid, glutamate, 5-hydroxytryptamine, histamine, monoamine oxidase and histaminase were studied in 45 (25M, 20F) hyperthyroid patients and 46 (25M, 21F) normal healthy volunteers. Increased levels of blood 5-hydroxytryptamine, histamine and glutamic acid were observed along with elevated T3 and T4, whereas plasma gamma-aminobutyric acid, monoamine oxidase and histaminase activities were found to be low in both male and female patients. After three months of treatment, circulating levels of 5-hydroxytryptamine, histamine and glutamic acid decreased significantly along with normalization of thyroid hormones and with an increase in the concentrations of gamma-aminobutyric acid, monoamine oxidase and histaminase. There was a positive correlation between these amines and thyroid hormone levels. The findings thus suggest that alterations in the metabolism of biogenic amines may be related to an altered metabolism in thyrotoxicosis, and these parameters may prove to be useful markers for diagnosis and follow-up of these patients.

Adult↗
PubMed1989

Blood bioamines, cortisol and aminoacid levels in leukemic patients.

In patients of chronic myeloid leukemia blood adrenaline, noradrenaline, dopamine and glutamate level were significantly elevated. The GABA levels were decreased along with no significant alterations in aspartate levels in these patients. In cases of acute myeloid leukemia only adrenaline and glutamate levels were enhanced with decreased GABA levels. However, plasma cortisol levels were significantly enhanced in both chronic and acute myeloid leukemia patients. These observations suggest that the circulating bioamines, cortisol and certain aminoacids level are considerably altered in chronic and acute myeloid leukemia. All these changes may possibly be attributed to the stress induced by the disease.

Adolescent↗
PubMed1984

Role of yoga in management of essential hypertension.

Twenty five patients of essential hypertension were studied. Of these, 20 patients were not given any antihypertensive drug treatment (Group A); other 5 had to be put on antihypertensive drugs before including them in the study (Group B). These patients were demonstrated "Shavasana" and trained to perform it correctly. Shavasana therapy was continued for six months. There was a statistically significant fall in both mean systolic and diastolic pressure of both groups. Further, there was a significant reduction in doses of antihypertensive drugs, being given to patients of group B. In 65% patients of group A, blood pressure could be controlled with Shavasana only and no drug was needed in them at all. Blood pressure rose significantly to pre-Shavasana levels in patients who left practising yoga. Thus, with use of yoga (Shavasana) in therapy of hypertension, requirement of antihypertensive drugs may be significantly decreased and in some cases may be totally dispensed with and it may be an useful adjunct in treatment of hypertension.

Adult↗
PubMed1982

Effect of indigenous drug (Pushkarmula) on experimentally induced myocardial infarction in rats.

In the present study, myocardial infarction was induced experimentally in rats by isoprenaline injection. Circulating GOT, LDH, CPK, cAMP, Cortisol, pyruvate, lactate glucose and cardiac cAMP adenyl cyclase levels were gradually increased and serum and cardiac cAMP-PDE levels were gradually decreased from 1 hour to 120 hours after the first injection of isoprenaline. In the rats pretreated with ciplar (beta blocker) or Pushkarmula (indigenous drug) these changes were less when compared to untreated infarcted rats. Similar type of results were also observed in the infarcted rats post treated with Pushkarmula. The pretreatment with Pushkarmula was found to be more effective than post treatment which gives a preventive and curative bearing of the drug in myocardial infarction.

Animals↗
PubMed1981

Immunological significance of lymphoreticular infiltration in gastrointestinal cancer.

The 60 patients of gastrointestinal cancer comprising this study were in the age range of 29--70 years with 39 males and 21 females. The primary sites of cancer were: gallbladder 19, colon 13, stomach 12, anorectum 8, and liver 8. The stage of tumor spread was localized in 32 and metastatic in 28 cases. Round cell infiltration scores were classified semiquantitatively from O-V. Cellular immunity as expressed by the blood lymphocyte count and DNCB reactivity was also studied. Round cell infiltration was dense in the localized group (P less than 0.0005). The mean lymphocyte counts in all the primary sites of gastrointestinal cancer were significantly higher in the localized group as compared to metastatic group. The DNCB reactivity showed anergy in six cases and poor response in the remaining 22 cases of metastatic group. There was a statistically significant correlation between lymphoreticular infiltration, peripheral blood lymphocyte count, and the DNCB reactivity. Diminished round cell infiltration, lymphopenia, and depressed DNCB response indicate an advanced stage of gastrointestinal cancer.

Adenocarcinoma↗