Biomedical subjects

K Nelissen

Publications and source records attributed to K Nelissen.

5 recordsLinked to original sources

PubMed2006

Spectrum of classical two-dimensional Coulomb clusters.

The frequency spectrum of a system of classical charged particles interacting through a Coulomb repulsive potential and which are confined in a two-dimensional parabolic trap is studied. It is shown that, apart from the well-known center-of-mass and breathing modes, which are independent of the number of particles in the cluster, there are more "universal" modes whose frequencies depend only slightly on the number of particles. To understand these modes the spectrum of excitations as a function of the number of particles is compared with the spectrum obtained in the hydrodynamic approach. The modes are classified according to their averaged vorticity and it is shown that these "universal" modes have the smallest vorticity and follow the hydrodynamic behavior.

Journal Article↗

PubMed2005

Structure, normal mode spectra, and mixing of a binary system of charged particles confined in a parabolic trap.

We study the mixing of two different kinds of particles, having different charge and/or mass, interacting through a pure Coulomb potential, and confined in a parabolic trap. The structure of the cluster and its normal mode spectrum are analyzed as a function of the ratio of the charges (mass ratio) of the two types of particles. We show that particles are not always arranged in a shell structure. Mixing of the particles goes hand in hand with a large number of metastable states. The normal modes of the system are obtained, and we find that some of the special modes can be tuned by varying the ratio between the charges (masses) of the two species. The degree of mixing of the two type of particles is summarized in a phase diagram, and an order parameter that describes quantitatively the mixing between particles is defined.

Journal Article↗

PubMed2005

Bubble, stripe, and ring phases in a two-dimensional cluster with competing interactions.

A system of classical charged particles confined in a two-dimensional trap and interacting through a competing short-range attraction and long-range repulsion potential is studied. The structure of the system strongly depends on the interaction range of the short-range attraction potential and the total number of particles. Depending on the appropriate choice of parameters for the attractive potential, the particles organize themselves in bubbles, stripe phases, and ringlike configurations, or combinations of both of them. Detailed phase diagrams are presented for systems consisting of N=2 up to N=6 particles. General rules are derived for the different subsequent transitions between those configurations and how the ground state configuration of a large system can be deduced from the one of a small number of particles.

Journal Article↗

PubMed2004

Influence of a defect particle on the structure of a classical two-dimensional cluster.

A system of classical charged particles interacting through a Coulomb repulsive potential which are confined in a two-dimensional parabolic trap is studied. We allow one or two particles, called defect particles, to have a different mass and/or charge than the other particles. The structure of the whole system depends on the mass and the charge of the defects and the total number of particles in the system. The ground state configurations are investigated and phase diagrams are constructed, which explain the recent experimental results of Phys. Rev. E 64, 11 603 (2001)]]. We found that several of the experimental configurations are metastable and that replacing the Coulomb interparticle potential by an inversely quadratic one has only a minor effect on the results.

Journal Article↗

PubMed2001

Visual motion processing investigated using contrast agent-enhanced fMRI in awake behaving monkeys.

To reduce the information gap between human neuroimaging and macaque physiology and anatomy, we mapped fMRI signals produced by moving and stationary stimuli (random dots or lines) in fixating monkeys. Functional sensitivity was increased by a factor of approximately 5 relative to the BOLD technique by injecting a contrast agent (monocrystalline iron oxide nanoparticle [MION]). Areas identified as motion sensitive included V2, V3, MT/V5, vMST, FST, VIP, and FEF (with moving dots), as well as V4, TE, LIP, and PIP (with random lines). These regions sensitive for moving dots are largely in agreement with monkey single unit data and (except for V3A) with human fMRI results. Moving lines activate some regions that have not been previously implicated in motion processing. Overall, the results clarify the relationship between the motion pathway and the dorsal stream in primates.

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