Biomedical subjects

K Neykov

Publications and source records attributed to K Neykov.

3 recordsLinked to original sources

PubMed1999

[Intravesical chemotherapy with mitomycin C after TUR for superficial bladder carcinoma].

Fifty-four patients mean aged 58.5 years (28 women and 26 men) undergo transurethral resection for superficial bladder carcinoma. Postoperatively 20 mg mitomycin is administered by instillation into the bladder for 8 weeks. Preoperative assessment includes: complete blood count, urea, creatinine, isotope nephrography, ultrasonography, excretory urography and CT scan of pelvis. Multifocal lesions are diagnosed in 22 patients (40.7%). In 36 cases (66.7%) it is a matter of solitary papillomas. The distribution of lesions is as follows: left bladder wall--12 patients (22.2%), right bladder wall--13 (24.07 per cent), trigone--18 (33.3%), and anterior bladder wall--11 (20.03 per cent). Postoperative check-ups: cytological assessment of urine and regular endoscopic study at 3-6 months. Recurrence rate amounts to 42.5% for the maximum follow-up period.

Administration, Intravesical↗

PubMed1999

[Bladder neck reconstruction after radical prostatectomy].

Experience had with radical prostatectomy in patients presenting localized prostate carcinoma is shared. A modified technique for new bladder-neck formation contributing to continence preservation is used in five patients, yielding very good postoperative results. In four cases a full recovery of continence is achieved within 3 months of the operation without resorting to drug therapy. In one case medical treatment with parasympaticolytics and agonists of voluntary sphincter is applied. The final outcome is stress incontinence only and passage of urine in the event of micturition postponed with 3-3.5 hours.

Carcinoma↗

PubMed1993

Solubility, inhibited growth and dissolution kinetics of calcium oxalate crystals in solutions, containing hippuric acid.

An analysis of crystal growth and dissolution of slightly soluble salts in physiological solutions in the presence of complexing ions was carried out, simulating conditions typical in human urine. It was found that hippuric acid, a normal physiological constituent of urine, acts at increased concentrations as a dissolving agent with respect to calcium oxalate (CaOx) and CaOx calculi. The kinetics of dissolution of crystalline CaOx calculi in physiological solutions containing hippuric acid at different concentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. Analysis of the experimental results enabled the determination of the increased solubility of CaOx in the presence of hippuric acid and the quantitative characterization of this substance as a new and promising agent for dissolving CaOx calculi in human urine. The possible effect of hippuric acid as a natural regulator of CaOx supersaturation and crystallization in human and mammalian urine is also discussed.

Calcium Oxalate↗