Biomedical subjects

K Niedzielska

Publications and source records attributed to K Niedzielska.

At least 19 recordsLinked to original sources

PubMed2003

Acquired factor VIII inhibitor in a non-haemophilic boy.

We describe the case of a previously healthy 8-year-old non-haemophilic boy who developed a factor VIII inhibitor of unknown origin. The symptoms of this disease were haemorrhages in the muscles of the right thigh, numerous bruises and a large haematoma of the right crus with subsequent tissue necrosis. Activated and non-activated prothrombin complex concentrates were administered in the therapy of the haemorrhages. To eliminate factor VIII inhibitor, the patient was treated first with prednisone, then immunoglobulin G and finally with a combination of prednisone and cycylophosphamide, without any effect. A total spontaneous remission was observed after 15 months from the beginning of the disease.

Blood Coagulation Factor Inhibitors↗

PubMed2001

Epidemiological studies on Creutzfeldt-Jakob disease in Poland.

The epidemiological, clinical and neuropathological study of Creutzfeldt-Jakob disease (CJD) in Poland was established in 1996. It was preceded by wide, repeated informative action among neurologists and psychiatrists in the whole country. The investigations were partially sponsored by the European Commission (E.C.) as part of the programme Biomed 1. The results obtained by us during the first three years of the study are presented in this paper. In 1996-1998 over 60 probable or possible cases of CJD (or information about them) were referred to our Institute. Neuropathologically typical changes for spongiform encephalopathy were found in 28 cases (among them four cases in laboratories of Medical Schools in Szczecin and Poznań). Neuropathological evaluation was based on paraffin slices stained by H-E, PAS, Bielschowsky, Kanzler-Arendt and Klüver-Barrera methods. In certain cases antibody 3F4 was used. In three patients only clinically probable CJD were diagnosed, since neuropathology was not done. In twenty-five persons, a detailed inquiry form was filled in after the model indicated by the E.C. As the result of processing the whole material, we diagnosed in twenty-four patients a sporadic form of CJD. The remaining case belonged to a family with Gerstmann-Sträussler-Scheinker syndrome. In sporadic CJD cases examined and observed by us no exogenic risk factors for the disease could be detected.

Adult↗

PubMed2000

Motor evoked potential studies in Creutzfeldt-Jakob disease.

OBJECTIVES: Motor evoked potentials (MEPs) were recorded in 7 cases of Creutzfeldt-Jakob disease (CJD) to asses the involvement of pyramidal motor pathways in these cases. The diagnosis of CJD was confirmed by autopsy in 5 cases and based on clinical data in two cases. METHODS: Transcranial (MEP-cortex), root magnetic (MEP-root) and electrical stimulation of peripheral nerves (F-wave, direct M-response) were performed. The cortical excitability threshold, F-wave frequency, MEP amplitudes, peripheral motor conduction velocity, standardized distal latencies and central, root, and F-wave conduction times were evaluated. RESULTS: The results of MEP testing were markedly abnormal. Cortical excitability thresholds were elevated, MEP amplitudes were reduced while the conduction function was rather preserved. The features of functional disturbances and/or loss of upper and lower motor neurons were revealed. They correlated with the advancement of key clinical CJD symptoms (progressive dementia, extrapyramidal and cerebellar signs, myoclonic jerks, mutism and typical periodic EEG changes), while motor lesion signs might only be slight or absent. CONCLUSIONS: Conduction slowing, if present, seemed to be secondary to axonal lesion.

Adult↗

PubMed1999

Quantitative measure of complexity of EEG signal dynamics.

Since electroencephalographic (EEG) signal may be considered chaotic, Nonlinear Dynamics and Deterministic Chaos Theory may supply effective quantitative descriptors of EEG dynamics and of underlying chaos in the brain. We have used Karhunen-Loeve decomposition of the covariance matrix of the EEG signal to analyse EEG signals of 4 healthy subjects, under drug-free condition and under the influence of Diazepam. We found that what we call KL-complexity of the signal differs profoundly for the signals registered in different EEG channels, from about 5-8 for signals in frontal channels up to 40 and more in occipital ones. But no consistency in the influence of Diazepam administration on KL-complexity is observed. We also estimated the embedding dimension of the EEG signals of the same subjects, which turned to be between 7 and 11, so endorsing the presumption about existence of low-dimensional chaotic attractor. We are sure that nonlinear time series analysis can be used to investigate the dynamics underlying the generation of EEG signal. This approach does not seem practical yet, but deserves further study.

Adult↗

PubMed1990

EEG and CT findings in poststroke epilepsy.

The present study was undertaken to assess the diagnostic value of CT in patients with poststroke epilepsy, related to EEG in revealing the factors contributing to the development of epileptic fits. The EEG and CT results were evaluated in 50 patients with poststroke epilepsy and compared with those of 50 patients without epilepsy after stroke. Cortical and extensive lesions involving the cortex were more frequent among patients with poststroke epilepsy. Sparing of certain parts of cerebral cortex was observed within vasogenic lesion. This type of change was only found in the poststroke epilepsy group and may be responsible for development of epileptic fits. It seems that CT has a higher diagnostic value than EEG in evaluating the risk of development of poststroke epilepsy.

Adolescent↗

PubMed1990

[Analysis of correlations between the content of various elements in hard tissues of milk teeth with and without caries].

Using the method of atomic absorption spectrometry the levels of calcium, magnesium, zinc, iron, strontium, nickel, manganese, copper were determined in the hard tissues of milk teeth with and without caries and the interrelations between these elements were analysed The obtained results were subjected to statistical analysis with an IMP 85 m computer. In the present study the analysis of the interrelations between elements was based on correlations and regression analyses. Many statistically significant interrelations were revealed between Mn and Fe, Mn and Zn, Mn and Cu, Mn and Ni, Fe and Zn, Fe and Cu, Fe and Ni, Zn and Cu, Zn and Ni. A decrease of the correlation coefficients was noted in carietic teeth. For the highly correlated elements equations of simple regression were calculated. A significant correlations was noted between caries and the levels of Mg, Zn, Fe, Sr, Ni, Mn, Cu in the hard tissues in milk teeth. The carietic milk teeth contained less Mg, Fe, Sr, Ni, Mn and Cu and much more Zn as compared to teeth without caries.

Dental Caries↗

PubMed1990

[The importance of trace elements in the aetiology of dental caries].

Data reported in the literature on the role of trace elements in the aetiology of dental caries are reviewed. The study of these elements--apart from fluorine--whose anticarietic or carietogenic effects have not yet been established, may shed new light on the carietic process and may contribute to a better knowledge of its cause.

Dental Caries↗

PubMed1989

[Strontium content in hard tissues of milk teeth with and without caries].

By the method of atomic absorption flame spectrophotometry the strontium level was determined in the hard tissues of milk teeth with and without caries. The studied material comprised 163 milk teeth, including 81 with caries. All teeth were obtained from children of either sex living in Lublin. The material was divided into three age groups: up to 6 years, 6-10 years, and over 10 years. The obtained results were subjected to statistical analysis using an IMP85 m computer. It was found age and sex had no significant effect on the strontium level in the hard tissues of healthy milk teeth. However, a significant correlation was observed between strontium level and caries presence. Milk teeth with caries contained less strontium than carietic teeth.

Child↗

PubMed1989

[Iron content of carious and non-carious milk teeth hard tissues].

Using the method of atomic absorption spectrophotometry the iron level was determined in the hard tissues of carietic and non-carietic milk teeth. The studied material comprised 163 milk teeth, including 81 with caries. All teeth were obtained from children of both sexes living in Lublin. The material was divided into age groups aged up to 6 years, 6-10 years and over 10 years. The obtained results were subjected to statistical analysis with an IMP 85 m computer. A significant correlation was found between the iron level in the hard tissues of the milk teeth and caries. The carietic milk teeth contained significantly less iron as compared to healthy teeth. The iron level in non-carietic milk teeth decreased with age. Sex was without effect on the level of this element in the dental hard tissues.

Child↗

PubMed1988