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Biomedical subjects

K Niemeyer

Publications and source records attributed to K Niemeyer.

7 recordsLinked to original sources
PubMed1992

[Clinical studies on the influence of Ornipressin (POR 8) on the cardiovascular system in general anesthesia].

A clinical prospective study of 231 patients was conducted to examine the influence of Ornipressin (POR 8) on the cardiovascular system. The standard concentration of the vasoconstrictor was 0.2 i.u./ml. A control group of 34 patients received 0.9% NaCl solution. In less than 10% of all cases blood pressure or pulse frequency changed up to 30 mmHg or 30 bp. m. Cardiac arrhythmias without clinical relevance could be observed sporadically. There were significant differences to the control group only in terms of pulse rate under volatile anaesthetics, and changes in blood pressure during the first 10 minutes under neurolept analgesia and under combined anaesthesia.

Adolescent↗
PubMed1978

[Clinical results in the treatment of chronic obstructive bronchitis with ambroxol in comparison with bromhexine (author's transl)].

Preclinical studies of trans-4-[(2-amino-3,5-dibromobenzyl)-amino]-cyclohexanol hydrochloride (ambroxol, NA 872), the metabolite VIII of bromhexine, show that it is superior to the basic substance with respect to its bronchosecretolytic properties. In a double blind study 30 patients suffering from chronic obstructive bronchitis received in randomized order 36 mg bromhexine/d or 45 mg ambroxol/d, each over a period of 4 weeks. The following parameters were studied: mean bronchial flow resistance, forced expiratory volume, static lung volumes, arterial blood gases as well as clinical and laboratory results. Bromhexine was not associated with a change in lung function parameters. Ambroxol was associated with a 25% reduction of the average bronchial flow resistance. The forced expiratory volume improved over the period on the average by 14%. Patients with slight arterial hypoxemia had an increase in the partial pressure of arterial oxygen. The patients found both substances facilitated expectoration. Further studies appear necessary to confirm the improved respiratory performance under the influence of ambroxol.

Adult↗