Direct antitumor effect of cepharanthin (CEP) and the combined effect with adriamycin (ADR), as well as the effect of CEP against body weight loss caused by treatment of ADR were evaluated using ICR mice bearing Ehrlich ascites tumor. Single administration of CEP reduced tumor growth compared to that of the untreated control, but not significantly. However, multiple administration of CEP reduced the tumor growth significantly compared to that of the untreated control (p < 0.001). Simultaneous administration of intratumoral CEP and intravenous ADR reduced the tumor growth significantly compared to that of ADR alone (p < 0.05). Further, CEP restored body weight loss caused by the treatment of ADR (p < 0.01). These findings indicate that the combined administration of CEP and ADR may be effective in cancer treatment.

Alkaloids↗

PubMedDate not supplied

Low dose sequential methotrexate and 5-fluorouracil administration is effective and safe as neo-adjuvant chemotherapy in oral cancer.

We report on the effects and complications associated with low dose sequential methotrexate (MTX) and 5-fluorouracil (5-FU) (MF therapy) as neo-adjuvant chemotherapy in oral cancer. The oral cancer of 19 patients was treated as follows: MTX (75 mg/body) was administrated by intravenous infusion for 1 hour, followed by 5-FU (500 mg/body) intravenous infusion for 2 hours, on Day 1. MTX (75 mg/body) intravenous infusion for 1 hour on Day 4. and parenteral dose of leucovorin on Day 2 and Day 5. A complete response was attained in one patient and a partial response in 11 patients. Complications observed were: increased serum transaminase levels (4), leucopenia (3). nausea or vomiting (4). anemia (1). The MF therapy of 2-8 courses was performed weekly or every 2 weeks. The volume in tumors of all cases decreased. Toxicity was extremely mild and radiotherapy or operation could be added sequentially without increased toxicity. These results suggests that MF therapy is effective and safety as neo-adjuvant chemotherapy before radiation and surgery for patients in oral cancer.

Adult↗

PubMedDate not supplied

Preservation of permanent teeth in a patient with Papillon-Lefèvre syndrome by professional tooth-cleaning.

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Adult↗