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Biomedical subjects

K Nordmann

Publications and source records attributed to K Nordmann.

3 recordsLinked to original sources

Removal of bone cement from the femoral canal using an acoustic emission-controlled milling device.

The removal of bone cement from the femoral canal in the case of hip prosthesis loosening takes a considerable amount of time and carries the additional risk of complications, thus risking bone damage and perhaps even endangering the successful reimplantation of a new prosthesis. We have demonstrated experimentally that the milling of bone and bone cement produces acoustic emission waves of different intensity. These waves can be measured by a commercial acoustic emission transducer. This method enables us to control a milling device during the removal of bone cement from deep in the femoral canal, avoiding the serious damage to the bone and thus enabling a new prosthesis to be reimplanted.

Acoustics↗

Mesna side effects which imitate vasculitis.

Mesna (sodium-2-mercaptoethansulfonate) is used in the prophylaxis of cyclophosphamide (CYC)-induced hemorrhagic cystitis. Four patients being treated with "low dose" CYC and prednisone for vasculitis developed severe side effects to Mesna. Fever, arthralgia, myalgia, tachycardia, electrocardiogram changes consistent with perimyocarditis, erythroderma, bullous skin and mucous membrane lesions, and abdominal complaints with profuse diarrhea were noted approximately 3 weeks after the initiation of therapy for CYC-induced leukopenia and a conservatively reduced prednisone dosage. Positive reexposure tests confirmed the association to Mesna use, and hypersensitivity skin tests demonstrated a delayed hypersensitivity reaction.

Adult↗